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Vemurafenib plx4032 rg7204

Manufactured by Selleck Chemicals
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Vemurafenib (PLX4032/RG7204) is a small-molecule inhibitor that targets the BRAF V600E mutation. It is used for research purposes in the study of signal transduction pathways and cellular processes.

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Lab products found in correlation

L nil, by Cayman Chemical (1 mentions) Dea nonoate, by Cayman Chemical (1 mentions) Cell culture reagents, by Thermo Fisher Scientific (1 mentions) Dithiothreitol (dtt), by Merck Group (1 mentions) Dabrafenib, by Selleck Chemicals (1 mentions) Selumetinib azd6244, by Selleck Chemicals (1 mentions) Chir99021, by Selleck Chemicals (1 mentions) Ly2090314, by Selleck Chemicals (1 mentions) Azd1080, by Selleck Chemicals (1 mentions) Mg132, by Selleck Chemicals (1 mentions)

2 protocols using vemurafenib plx4032 rg7204

1

Vasodilator and Antioxidant Compounds

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L-NIL (hydrochloride) and DEANONOate were purchased from Cayman Chemical (Ann. Harbor, MI). PTIO, SNAP, and Dithiothreitol were from Sigma-Aldrich (St. Louis, MO). Vemurafenib (PLX4032/RG7204) from Selleckchem (Houston, TX). All chemicals were prepared freshly from powdered stock on the day of each experiment. All cell culture reagents were from Invitrogen.
Lopez-Rivera E., Jayaraman P., Parikh F., Davies M.A., Ekmekcioglu S., Izadmehr S., Milton D.R., Chipuk J.E., Grimm E.A., Estrada Y., Aguirre-Ghiso J, & Sikora A.G. (2014). Inducible nitric oxide synthase (iNOS) drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2. Cancer research, 74(4), 1067-1078.
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2

Small Molecule Inhibitor Screening

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CHIR99021 (S1263, Selleckchem, distributed by LuBioScience, Zurich, Switzerland) was used at different concentrations. LY2090314 (S7063, Selleckchem) was used at 100 nM. AZD1080 (S7145, Selleckchem) was used at 10 µM. Vemurafenib (PLX4032, RG7204), (S1267, Selleckchem) was used at 1 μM. Dabrafenib (S2807, Sellechchem) was used at 1 μM. Selumetinib (AZD6244), (S1008, Selleckchem) was used at 1 μM MG-132, (S2619, Selleckchem) was used at 20 μM.
Uka R., Britschgi C., Krättli A., Matter C., Mihic D., Okoniewski M.J., Gualandi M., Stupp R., Cinelli P., Dummer R., Levesque M.P, & Shakhova O. (2020). Temporal activation of WNT/β-catenin signaling is sufficient to inhibit SOX10 expression and block melanoma growth. Oncogene, 39(20), 4132-4154.
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