Triisopropylsilane

Fmoc-protected amino acids were purchased from CEM Corporation, and Pepceuticals. N, N-Dimethylformamide (DMF) and diethyl ether (Et₂O) were purchased from Rathburn. Triisopropylsilane (TIPS), Trifluoroacetic acid (TFA), N, N-Diisopropylethylamine (DIPEA), N,N’-diisopropylcarbodiimide (DIC), ethyl cyano (hydroxyimino) acetate (Oxyma Pure), fluorescein-5-isothiocyanate (FITC), Fmoc-Lys(Alloc)-OH, Tetrakis(triphenylphosphine)palladium(0) {Pd(PPh₃)₄)}, and phenylsilane were purchased from Fluorochem. Morpholine was purchased from Alfa Aesar. Dichloromethane (DCM) was purchased from VWR. Acetonitrile (MeCN) was purchased from Honeywell. TentaGel S RAM resin was purchased from Rapp Polymere. All other reagents were purchased from Sigma Aldrich.

Fmoc-d-Ile-OH, Fmoc-d-Thr(Trt)-OH, and oxyma pure were purchased from Merck Millipore (Watford, UK). All l-amino acids, 1-[Bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU), Fmoc-d-Gln(Trt)-OH, Boc-d-Nmethylphenyl-OH, Fmoc-d-Cys-OH, Fmoc-l-Cys-OH, Fmoc-Glu(OAll)-OH, Diisoproplycarbodiimide, and Triisopropylsilane were purchased from Fluorochem, Hadfield, UK. The protecting groups for the amino acids are Pbf for Arg and Trt for Gln, unless specified otherwise. Diisopropylethylamine, supplied as extra-dry, redistilled, and 99.5% pure, was purchased from Sigma Aldrich (Gillingham, UK). Peptide-synthesis grade Dimmethylformamide (DMF) and Trifluoroacetic acid (TFA) was purchased from Rathburn chemicals (Walkerburn, UK). Diethyl ether, i-PrOH, MeOH (HPLC grade), and Acetonitrile (HPLC grade) were purchased from Fisher Scientific (Loughborough, UK). Water with the Milli-Q grade standard was obtained in-house from an ELGA Purelab Flex system. Rink amide Chemmatrix resin (manufacturer’s loading = 0.49 mmol/g) was obtained from Biotage, Uppsala, Sweden. All chemicals were used without further purification.