Spss statistical package version 15.0

Statistical analyses were performed using SPSS statistical package (version 15.0) (IBM, SPSS Inc., Chicago, USA) and SNP STAT an online tool (Sole et al., 2006) . The associations between PTEN-L rs12573787 and CML were performed by multivariate logistic regression analysis. Odds ratios (OR) and their corresponding 95% confidence intervals (CI 95%) were calculated. Hardy-Weinberg equilibrium (HWE) was tested using a goodness-of-fit Chi-square test. Standard genetic models (additive, recessive and dominant) for disease penetrance were evaluated using SNP STAT. All statistical tests were two-sided and values of p < 0.05 were considered statistically significant.

Statistical analyses were performed using PLINK software and SPSS statistical package (version 15.0) (IBM, SPSS Inc., Chicago, USA). The association between polymorphisms and CML was performed using logistic regression analysis adjusted by age and sex. The estimating of odds ratios (OR) and their corresponding 95% confidence intervals (CIs) were calculated. For GSTP1 Hardy-Weinberg equilibrium (HWE) was tested using a goodness-of-fit Chi-square test and standard genetic models (additive, recessive and dominant) for disease penetrance were evaluated. For GSTM1 and GSTT1 we considered only a recessive model since the PCR-assay does not distinguish between homozygote wild type and heterozygous genotypes. We also assessed combined genetic polymorphisms on CML risk using logistic regression analysis. The Kaplan-Meier method was performed to estimate survival curves, and the log-rank test was used to compare the stratified genotype