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Magnetom symphony 1 5t

Manufactured by Siemens
Sourced in Germany

The Magnetom Symphony 1.5T is a magnetic resonance imaging (MRI) system manufactured by Siemens. It operates at a magnetic field strength of 1.5 Tesla, which is a common field strength for clinical MRI scanners. The core function of the Magnetom Symphony 1.5T is to generate high-quality images of the human body for diagnostic and clinical purposes.

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9 protocols using magnetom symphony 1 5t

1

Multimodal MRI Imaging Protocol for Brain Diagnostics

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All images were acquired in the clinical diagnostic routine using a 1.5Tesla MRI system (Siemens Magnetom Symphony 1,5T) with the standard Siemens head coil (CP head array, model #1P3146037). DWI was performed using a single shot echo planar sequence with following parameters: Echo time(TE)/Repetition time(TR) = 6000/105 ms, 90° flip angle, 57 transverse sections, slice thickness = 5 mm, field of view (FOV) = 230 mm. Diffusion-sensitizing gradients were applied sequentially in the x, y and z directions with b factors of 0 and 1000 s/mm2. ADC maps were then automatically generated by the operating console of the MR scanner. Postcontrast T1-weighted 3D-gradient echo sequence(GRE) imaging was obtained with following parameters: TR/TE = 2150/3.93 ms, flip angle 15°, 1-mm section thickness and 230 mm FOV. A standard dose (0.1 mmol/kg body weight) of gadolinium based contrast agent (Gadovist, Bayer, Leverkusen, Germany) was injected intravenously. Routine anatomic precontrast T1/T2_tirm_tra_dark_fluid (TR/TE = 9000/114, slice thickness 5mm, flip angle 150°, 28 transverse sections) images were also obtained.
All images were available in digital form and analyzed by one experienced radiologist (SS) without knowledge of the histopathological diagnosis on a PACS workstation (syngo.plaza VB20, Siemens, Germany).
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2

MRI Protocol for Diffusion and Contrast Imaging

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All images were obtained in the clinical routine workup by using a 1.5T MRI scanner (Siemens Magnetom Symphony 1,5T) with the standard Siemens head coil (CP head array, model #1P3146037). DWI was performed using a single-shot spin-echo (SE) echo planar sequence with following parameters: Echo time(TE)/Repetition time(TR) = 6000/105 ms, 90° flip angle, 57 transverse sections, slice thickness = 5 mm, field of view (FOV) = 230 mm. Diffusion-sensitizing gradients were applied sequentially in the x, y and z directions with b factors of 0 and 1000 s/mm2. ADCs were automatically calculated at the operating console of the MR scanner and displayed as corresponding ADC maps. Postcontrast T1-weighted 3D-gradient echo sequence(GRE) imaging was obtained with following parameters: TR/TE = 2150/3.93 ms, flip angle 15°, 1-mm section thickness and 230 mm FOV. A standard dose (0.1 mmol/kg body weight) of gadoteric acid (Gd-DOTA, Dotarem; Laboratoire Guerbet, Aulnay-sous-Bois, France) was injected intravenously. Routine anatomic precontrast T1/ T2_tirm_tra_dark_fluid (TR/TE = 9000/114, slice thickness 5mm, flip angle 150°, 28 transverse sections) images were also obtained.
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3

Neck MRI Protocol for Contrast Enhancement

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MR images were obtained using two distinct MR scanners, specifically Siemens Magnetom Symphony 1.5 T and Siemens Skyra 3.0 T. Cross-sectional T1-weighted images (T1WI) and fast spin-echo T2-weighted images (fs T2WI) were initially acquired. Subsequently, axial fast spin-echo contrast-enhanced T1-weighted images (fs CE-T1WI) were obtained following the administration of a gadolinium-based contrast agent at a dosage of 0.01 mmol/kg. While recommendations for neck MRI slightly varied, the protocol primarily comprised the following parameters: 1) axial T1WI: TR/TE 1700–1800 ms/910 ms, flip angle of 90°, matrix of 256 × 168, slice thickness of 5.00 mm, and slice spacing of 1.00 mm; 2) axial fs T2WI: TR/TE 5700–6360 ms/4995 ms, flip angle of 90°, matrix of 256 × 168, slice thickness of 5.00 mm, and slice spacing of 1.00 mm; 3) axial fs CE-T1WI: TR/TE 450–605 ms/8.89 ms, flip angle of 90°, matrix of 256 × 168, slice thickness of 5.00 mm, and slice spacing of 1.00 mm.
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4

Cardiac MRI Assessment in Pediatric Cohorts

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CMR examinations were performed on two different 1.5 T whole body MR scanners (Magnetom Symphony 1.5 T, Siemens Healthcare, Erlangen, Germany, and Signa 1.5 T, GE Healthcare, Chalfont St Giles, Great Britain) using a phased-array surface coil in supine position. Some of the younger probands (<6 years) needed a mild sedation. However, general anesthesia was required in none of the subjects. A vector electrocardiogram was used for R-wave triggering. Cine images of short axis views, normally covering the entire LV from base to apex, as well as of 3- and 4-chamber views were acquired using a standard SSFP sequence. Imaging parameters were TE 1.1–1.2 ms, TR 40–42 ms, flip angle 80°, field of view (FOV) 160–190 mm x 125–156 mm, matrix 256 × 256 and slice thickness 4–8 mm for the Magnetom Symphony scanner and TE 1.5 ms, TR 3.5 ms, flip angle 45°, FOV 280–370 mm, phase FOV 0.75, matrix 160 × 128 and slice thickness 7–10 mm for the Signa scanner. The number of acquired phases at the Magnetom scanner varied between 20 and 50 per cardiac cycle. Series with a low number of phases were mostly acquired in children with high heart rates. Thus, the temporal resolution was 20.3 (19.0 to 25.6) ms. At the Signa scanner, 30 phases per cardiac cycle were reconstructed consistently resulting in a temporal resolution of 24.7 (22.4 to 27.4) ms.
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5

Neck MRI Imaging Protocol

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MRI images of all patients were obtained using two different MRI scanners (Siemens Magnetom Symphony 1.5T and Siemens SKyra 3.0T, Munich, Germany). Axial FS T2WI images were initially obtained, followed by axial FS CE-T1WI imaging after gadolinium-based contrast agent administration at 0.01 mmol/kg. The acquisition protocol for neck MRI was slightly different but mainly consisted of the following parameters: 1) axial FS T2WI, repetition time/echo time (TR/TE) 6,360 ms/95 ms, 90° flip angle, 256 × 168 matrix, slice thickness 4.68 mm, slice spacing 4.68 mm; and 2) axial FS CE-T1WI TR/TE 450 ms/8.8 ms, 90° flip angle, 256 × 168 matrix, slice thickness 4.68 mm, slice spacing 4.68 mm.
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6

Standardized MRI Acquisition Protocol

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MR images were obtained from all patients using two different MRI scanners (Siemens Magnetom Symphony 1.5T and Siemens SKyra 3.0T, Munich, Germany) before treatment and after IC, with an interval of 1–2 months. Standard head coil was used for scanning, Conventional MRI scans T1-weighted imaging (T1WI) were obtained at the following parameters: (1) 3.0T MRI scan parameters: transverse T1WI repetition time (TR) 1800 ms, echo time (TE) 9.4 ms, 320*75 matrix, 1.0*0.7*5.0 mm; (2) 1.5T MRI scan parameters: transverse T1WI TR 380 ms, TE 7.0 ms, 304*80 matrix, 1.07*0.86*5.0 mm. The remaining parameters were consistent for both instruments: slice thickness 5 mm, interslice distance 5 mm, field of view (FOV) = 240 × 230 mm, 90° flip angle.
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7

Post-Operative MRI Evaluation of Patients

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MRI (Magnetom Symphony 1.5 T; Siemens) was performed at 6 or 12 months postoperatively in 14 patients and was repeated in some patients. Conventional MRI sequences, including T1-weighted, T2-weighted, and short tau inversion recovery (STIR) imaging, were performed in the sagittal plane. Assessment was performed for changes in underlying bone in T1-weighted images and for articular congruity including cartilage signal in T2-weighted and STIR images. Results were assessed as normal or near-normal or as abnormal according to the criteria described by Roberts et al21 (link) (Appendix Table A3).
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8

Cardiac Shunt Assessment using CMR

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CMR studies were performed on a 1.5 T or 3T scanner (Siemens Magnetom Symphony 1.5 T or Avanto 1.5 T or Siemens Magnetom Skyra 3 T). Morphological evaluation of cardiac shunts was provided by T1 spin echo black blood sequence. For assessing cardiac function and localisation of the shunt cine images were acquired by fast imaging with steady-state precession. Short axis stack and long-axis cine images were used to determine a difference between left and right ventricular stroke volumes to calculate shunt volume.
In addition, velocity encoded (VENC) phase contrast MR was used for quantification of vascular flow. VENC images were acquired perpendicular to the ascending aorta and main PA. Through-plane flow was assessed just above the pulmonary and aortic valves. Appropriate VENC was chosen (started with 150 ms). Shunt fraction was calculated by measuring the ratio of pulmonary blood flow (Qp) to Qs.
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9

Radiosynthesis and PET Imaging of (S)-18F-THK5117

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The radiosynthesis of (S)-18 F-THK5117 is described in the supplemental material (available at http://jnm.snmjournals.org). All (S)-18 F-THK5117 PET scans were obtained on an ECAT Exact HR1 (Siemens) stand-alone PET scanner. After a 10-min transmission scan with rotating 68 Ge rod sources, (S)-18 F-THK5117 (3 MBq/kg) was administered as a fast bolus, simultaneously with the start of a 90-min dynamic PET acquisition (6 • 10, 3 • 20, 2 • 30, 2 • 60, 2 • 150, 4 • 300, and 6 • 600 s). Images were reconstructed using normalization-and attenuationweighted ordered-subset expectation maximization (6 iterations, 8 subsets) applying all appropriate corrections and a 4-mm Hanning postprocessing filter. In addition, all patients underwent a T1-weighted MRI scan, which was used for segmentation and volume-of-interest (VOI) definition. The AD patients and MCI patients underwent MRI scans on a Magnetom Symphony 1.5-T (Siemens; n 5 2 and 1, respectively), Magnetom Trio 3-T (Siemens; n 5 2 and 1, respectively), or Achieva 1.5-T (Philips; n 5 1 and 2, respectively) scanner. The dynamic PET data were realigned to correct for interframe patient movement using Voiager software (GE Healthcare).
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