Data were acquired using a 1.5 T Siemens MAGNETOM Avanto scanner. A transmit receive head coil was used to minimize exposure of DBS electrodes to the pulsed radiofrequency field. The DBS was turned off 2 min prior to scanning and programmed at 0 V in bipolar mode. The subject’s head was held in place with padding and straps. Specific absorption rate was limited to 0.1 W/kg. Structural images were acquired with 1 × 1 × 1 mm resolution using a 3D sagittal MPRAGE with repetition time of 1.9 s, echo time of 3.08 ms, flip angle of 8° and inversion time of 1.1 s. Functional MRI data were acquired with 2D echo-planar imaging with repetition time = 2000 ms, echo time = 30 ms, flip angle = 90°. Each scan consisted of 25 transverse slices of 4-mm thick with in plane voxel size of 3.6 × 3.6 mm and slice gap of 0.4 mm. The first 10 volumes were discarded to allow for magnetization stabilization and the subsequent 180 volumes were analysed.
Magnetom avanto scanner
Manufactured by Siemens
Sourced in Germany
The Magnetom Avanto scanner is a magnetic resonance imaging (MRI) system designed and manufactured by Siemens. It is a powerful diagnostic tool used to generate detailed images of the human body's internal structures. The Magnetom Avanto employs advanced magnetic and radio frequency technologies to capture high-resolution images that assist healthcare professionals in the diagnosis and monitoring of various medical conditions.
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Lab products found in correlation
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Magnetom verio scanner, by Siemens (2 mentions)
Verio scanner, by Siemens (1 mentions)
Prisma 3t scanner, by Siemens (1 mentions)
Inova 600, by Agilent Technologies (1 mentions)
Gd hpdo3a, by Bracco (1 mentions)
6 element design, by Siemens (1 mentions)
Osirix, by Pixmeo (1 mentions)
Dotarem, by Guerbet (1 mentions)
Impax, by AGFA HealthCare (1 mentions)
Tim trio scanner, by Siemens (1 mentions)
Magnetom skyra scanner, by Siemens (1 mentions)
Mimics software, by Materialise (1 mentions)
Achieva quasar dual scanner, by Philips (1 mentions)
30 protocols using magnetom avanto scanner
1
fMRI of Deep Brain Stimulation Effects
2
Brain Imaging Protocols for Multicohort Studies
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The scanning parameters differed slightly for the two study cohorts. For the Canadian volunteers, 3D-MPRAGE structural images of the brain were collected on a 1.5 T Siemens Magnetom Avanto scanner. Sequence parameters were TR = 2240 ms, TE = 9.2 ms, FA = 10°, FOV = 256 × 256 mm, acquisition matrix = 256 × 256, in-plane resolution = 1.91 mm, slice thickness = 1 mm). For the Copenhagen cohort, structural scans were acquired on a 3 T Siemens Verio scanner with a 32-channel head coil using a 3D T1-weighted MPRAGE sequence (TR = 1900 ms, TE = 2.32 ms, FA = 9°, isotropic 0.93 mm3 voxels).
3
Longitudinal Multimodal Brain Imaging
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MR images were acquired at two time points (2011 and 2015) on the same 1.5-Tesla Siemens Magnetom Avanto scanner and included the following whole brain scans: T1-weighted 3D MPRAGE imaging (isotropic voxel size 1.0 mm3), a FLAIR sequence (voxel size 0.5 × 0.5 × 2.5 mm; interslice gap 0.5 mm) and a DTI sequence (isotropic voxel size 2.5 mm3, 8 unweighted scans, 60 diffusion weighted scans at b = =900 s/mm2). Full acquisition details have been described previously (van Leijsen et al., 2017 (link); van Norden et al., 2011 (link)).
4
Structural Brain Imaging with PiB PET
5
Multiparametric MRI Acquisition Protocol for Prostate Cancer
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Routine clinical mpMRI acquisition includes T2, DCE-MRI, and DWI. The DWI includes an apparent diffusion coefficient (ADC) map generated at the time of acquisition. Patients were injected with contrast agent Gadoteridol (Gd-HP-DO3A; Pro Hance, Bracco Diagnostics, Princeton, NJ, USA) with a dose of 0.1 mL/kg before DCE-MRI acquisition. All patients were imaged using MAGNETOM-Avanto scanner (Siemens Healthcare, Erlangen, Germany) at 1.5 T with both endorectal coil and phase-array pelvic coil24 (link). More details on the technical parameters of the MRI sequences are shown in Supplementary Table S1 .
6
High-Resolution MRI Brainstem Imaging Protocol
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3D high-resolution T1weighted MR imaging data (MPRAGE) were obtained from 110 HS (mean age 34.9 years, median age 30.9 years, range 18–72 years, SD 12.8, 53.6% women) on 1.5T (45%) and 3T (55%) scanners with two different protocols, respectively.
Briefly, acquisition parameters for the 1.5T Magnetom Avanto scanner (Siemens Healthineers, Erlangen, Germany) were TR = 2,080 ms, TI = 1,100 ms, TE = 3 ms, α = 15°, spatial resolution of 0.98 × 0.98 × 1 mm3 (Bendfeldt et al., 2009 (link); Weier et al., 2014 (link)) and TR = 2,700 ms, TI = 950 ms, TE = 5 ms, α = 8°, spatial resolution of 1 × 1 × 1 mm3. For the 3T Prisma scanner (Siemens Healthineers, Erlangen, Germany) acquisition parameters were TR = 1,680 ms, TI = 900 ms, TE = 2.5 ms, α = 8°, spatial resolution of 1 × 1 × 1 mm3 and TR = 2,300 ms, TI = 900 ms, TE = 3 ms, α = 9°, spatial resolution of 1 × 1 × 1 mm3, acceleration factor 2.
Written informed consent was obtained from all participants mentioned above.
All brainstem segmentations were visually inspected for anatomic accuracy.
Briefly, acquisition parameters for the 1.5T Magnetom Avanto scanner (Siemens Healthineers, Erlangen, Germany) were TR = 2,080 ms, TI = 1,100 ms, TE = 3 ms, α = 15°, spatial resolution of 0.98 × 0.98 × 1 mm3 (Bendfeldt et al., 2009 (link); Weier et al., 2014 (link)) and TR = 2,700 ms, TI = 950 ms, TE = 5 ms, α = 8°, spatial resolution of 1 × 1 × 1 mm3. For the 3T Prisma scanner (Siemens Healthineers, Erlangen, Germany) acquisition parameters were TR = 1,680 ms, TI = 900 ms, TE = 2.5 ms, α = 8°, spatial resolution of 1 × 1 × 1 mm3 and TR = 2,300 ms, TI = 900 ms, TE = 3 ms, α = 9°, spatial resolution of 1 × 1 × 1 mm3, acceleration factor 2.
Written informed consent was obtained from all participants mentioned above.
All brainstem segmentations were visually inspected for anatomic accuracy.
7
Multimodal neuroimaging of cognitive function
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Only participants who had undergone structural MRI, DTI, and spectroscopic data were included in the study. All MRI scans were acquired on a 1.5T Siemens Magnetom Avanto scanner. Structural MR images were acquired using a FLASH sequence with TR/TE = 11/4.95 ms, slice thickness = 1 mm, flip angle = 15°, matrix size = 256 × 256, and voxel size = 1 mm × 1 mm × 1 mm. For DTI, we used a single-shot spin-echo echo-planar sequence with diffusion gradients along 30 noncollinear directions with parameters TR/TE = 6000/88 ms, slice thickness = 3 mm with 1.5 mm gap averaged twice a b value of 0 and 1000 s/mm2. We also performed 1H MRS acquisitions using PRESS sequence with water suppression by means of CHESS sequence. The two-dimensional chemical shift (2D CSI) multivoxel sequence with a TR/TE = 1590/30 ms, NEX = 3, bandwidth = 10 kHz, and data points = 2048 was used for the examinations.1 H MRS voxels of 1.6 cm × 1.6 cm × 2.5 cm were placed over the posterior cingulate gyri on the midsagittal slice covering posterior cingulate gyri and inferior precunei bilaterally [Supplementary Figure 1 ].
8
Longitudinal Relaxometry of Glucose-Functionalized SPIONs
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Longitudinal relaxivity (R1) was measured at 14.1 T on an Agilent Inova 600. Five solutions with variable nanoparticle concentrations ([Fe] between 1 and 10 mM) were prepared by dissolving them in 0.3M NaHCO3 in D2O and measuring the HDO-T1 by standard inversion recovery. The relaxation rates for each solution were corrected by subtracting the relaxation rate of the blank.
MR images were taken at 1.5 T on a Siemens Magnetom Avanto scanner.
A T1 sequence was applied: TE = 13 ms TR = 739 ms. A variable number of Eppendorf vials filled with the Glc-SPION solutions at increasing concentrations or with the cell suspensions to be analysed were placed in a rack and scanned.
For the imaging of the Glc-SPION solutions, we used the following concentrations: 1,2,4,6,8,10 mg/mL.
For cell suspension, we used BCPAP cells, which were treated for 6h with different concentrations of Glc-SPION (0.25, 0.50, 1.00 mg/mL). After treatment, the cells were centrifuged and washed to remove the growth medium containing the Glc-SPIONs and resuspended in fresh (Glc-SPION-free) growth medium.
MR images were taken at 1.5 T on a Siemens Magnetom Avanto scanner.
A T1 sequence was applied: TE = 13 ms TR = 739 ms. A variable number of Eppendorf vials filled with the Glc-SPION solutions at increasing concentrations or with the cell suspensions to be analysed were placed in a rack and scanned.
For the imaging of the Glc-SPION solutions, we used the following concentrations: 1,2,4,6,8,10 mg/mL.
For cell suspension, we used BCPAP cells, which were treated for 6h with different concentrations of Glc-SPION (0.25, 0.50, 1.00 mg/mL). After treatment, the cells were centrifuged and washed to remove the growth medium containing the Glc-SPIONs and resuspended in fresh (Glc-SPION-free) growth medium.
9
Cardiac Imaging Protocol for Dilated Cardiomyopathy
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The following demographics and hemodynamic parameters were collected from 3 patients diagnosed with dilated cardiomyopathy at Great Ormond Street Hospital for Children, London, UK, by searching the clinical database: age, gender, heart rate, cardiac output, left and right ventricular end-systolic and end-diastolic volumes, systolic and diastolic aortic pressures. The patients were selected to simulate mild and severe dilated cardiomyopathy in the left ventricle and biventricular dysfunction.
Cardiac magnetic resonance images (1.5-Tesla Magnetom Avanto scanner, Siemens Medical Solutions, Erlangen, Germany) were reviewed for these patients. The steady-state free precession sequences acquired at both end-diastole, and end-systole, were used to measure cardiac dimensions in Simpleware ScanIP 2018 (Synopsis, CA, USA). Four-chamber view was used to measure left and right ventricular long axis length and right ventricular basal diameter; the short-axis view was used to measure left ventricular lateral-septal diameter.
Cardiac magnetic resonance images (1.5-Tesla Magnetom Avanto scanner, Siemens Medical Solutions, Erlangen, Germany) were reviewed for these patients. The steady-state free precession sequences acquired at both end-diastole, and end-systole, were used to measure cardiac dimensions in Simpleware ScanIP 2018 (Synopsis, CA, USA). Four-chamber view was used to measure left and right ventricular long axis length and right ventricular basal diameter; the short-axis view was used to measure left ventricular lateral-septal diameter.
10
Velocity-encoded Phase-contrast CMR Protocol
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All scans were performed on a 1.5 Tesla Magnetom AVANTO-scanner (Siemens, Erlangen, Germany). The velocity-encoded phase-contrast sequence used in this study is a component of our generally used CMR protocol [17 (link), 18 (link)]. Velocity encoding was set to 150 cm/s and was adjusted in the case of aliasing. Spatial resolution was 1.33 mm x 1.33 mm x 8 mm. Repetition time (TR) was 13.56 ms. Retrospective ECG triggering with 128 phases per cardiac cycle was applied. The mean heart rate during CMR scans was 66 ± 11 beats per minute. Consequently, the reconstructed mean temporal resolution was 7.1 ms.
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