Nano series zen 4003 zetasizer

Manufactured by Malvern Panalytical

Sourced in United Kingdom

The Nano Series Zen 4003 Zetasizer is a dynamic light scattering instrument that measures the size and size distribution of particles in a sample. It is capable of measuring particle sizes ranging from 0.3 nanometers to 10 micrometers.

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Lab products found in correlation

Lambda 35, by PerkinElmer (1 mentions) Microtof 2 mass spectrometer, by Bruker (1 mentions) Concanavalin a (cona), by Vector Laboratories (1 mentions) Avance spectrospin 500 spectrometer, by Bruker (1 mentions) Avance dpx 200 nmr spectrometer, by Bruker (1 mentions) Rifampicin, by Merck Group (1 mentions) Jem 1230, by JEOL (1 mentions) High performance liquid chromatography (hplc), by Agilent Technologies (1 mentions)

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5 protocols using nano series zen 4003 zetasizer

Evaluating Micelle Responsiveness to ROS

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Particle size, polydispersity index (PDI) and zeta potential values of the micelles were measured using a Nano Series Zen 4003 Zetasizer (Malvern Instruments Ltd., Malvern, UK). To evaluate the ROS responsiveness of micelles, TK-FA-Cur-Ms were incubated with hydrogen peroxide (H₂O₂) for 2 h at 37°C. Then particle size, PDI and zeta potential were evaluated after incubation.

Wang Y., Guo R., Zou M., Jiang L., Kong L., Zhao S., Zhang X., Wang W, & Xu B. (2024). Combined ROS Sensitive Folate Receptor Targeted Micellar Formulations of Curcumin Effective Against Rheumatoid Arthritis in Rat Model. International Journal of Nanomedicine, 19, 4217-4234.

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Glycolipid Nanoparticle Synthesis and Characterization

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Rifampicin was purchased from MilliporeSigma (St. Louis, MO). Except for the glycolipids Man-DPPE and G7-DPPE, which were synthesized as shown below, all other lipids used in this study were purchased from Avanti Polar Lipids (Alabaster, Alabama). Con A was purchased from Vector Laboratories. Other reagents were purchased from either MilliporeSigma or Fisher Scientific (Hampton, NH) and were used without further purification unless otherwise noted. The experimental details for the syntheses of compounds 14–17 can be found in the Supporting Information. Polycarbonate membranes (0.1 μm, 19 mm) were purchased from Avanti Polar Lipid. ¹H NMR and ¹³C NMR spectra were recorded on a Bruker Avance Spectrospin-500 spectrometer or a Bruker Avance DPX 200 NMR spectrometer. ³¹P NMR spectra were recorded on a Bruker Avance DPX 200 NMR spectrometer using 85% H₃PO₄ (0.00 ppm) as the external reference. HRMS spectra were collected in the electrospray ionization (ESI) mode on a Bruker MicrOTOF II mass spectrometer at the University of Massachusetts Amherst. UV–vis spectra were collected on a Perkin Elmer LAMBDA 35 UV–vis spectrophotometer. Dynamic light scattering (DLS) measurements were carried out on a Nano Series Zen 40 03 Zetasizer (Malvern Instruments Ltd, Malvern, UK).

Wu B., Ndugire W., Chen X, & Yan M. (2021). Maltoheptaose-Presenting Nanoscale Glycoliposomes for the Delivery of Rifampicin to E. coli. ACS applied nano materials, 4(7), 7343-7357.

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Characterization and Stability of Nanoparticle Formulations

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The particle size, polydispersity index, and zeta potential values were measured using Nano Series Zen 4003 Zetasizer (Malvern Instruments Ltd).33 The suspension stability of ACNP, ACNP-DOX, ACNP-DSPE-PEG2000, ACNP-DOX-DSPE-PEG2000 and the NDDS, ACNP-DOX-DSPE-PEG2000-anti-CD20 in PBS (10 mM, pH 7.4) were observed by mixing 1 mg of corresponding preparation in 2 mL of PBS, followed by sonication for 30 minutes at room temperature.
The stability of the compound was evaluated after 1 month. The size and morphology of the ACNP-DOX, ACNP-DSPE-PEG2000, ACNP-DOX-DSPE-PEG2000 and the NDDS, ACNP-DOX-DSPE-PEG2000-anti-CD20 were evaluated using transmission electron microscopy (TEM) (Hitachi H7650, Hitachi Ltd., Tokyo, Japan). Each 0.1 mg/mL of sample was resuspended in water and mixed by sonication for 30 seconds. One drop of this suspension was placed on a carbon-coated copper TEM grid (200 mesh, Sangerbio, People’s Republic of China) and allowed to dry at room temperature. The samples were imaged at 80 kV with TEM. The absorption spectra were recorded in the range 200–900 nm using a UV–visible absorption spectrometer. Fluorescence spectra were recorded by a FluoroLog steady-state spectrofluorometer (excitation at 488 nm) with the same DOX concentration.34

Jiang S., Wang X., Zhang Z., Sun L., Pu Y., Yao H., Li J., Liu Y., Zhang Y, & Zhang W. (2016). CD20 monoclonal antibody targeted nanoscale drug delivery system for doxorubicin chemotherapy: an in vitro study of cell lysis of CD20-positive Raji cells. International Journal of Nanomedicine, 11, 5505-5518.

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Particle Size and Morphology of AS-BSA-NPs

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The ABNI and the ABNA were chosen for the particle-size and morphology examination, and the AS concentration of both was 2 mg/mL. After dilution with distilled water, the mean grain size and polydispersity index of AS-BSA-NPs were determined by dynamic light scattering using a Nano series Zen 4003 Zetasizer (Malvern Instruments, Malvern, UK), with the following parameters: 298 K, running 15 times, equilibrium time of 60 seconds. Transmission electron microscopy (TEM) was used to observe and confirm the morphology of the AS-BSA-NPs (JEM-1230; JEOL, Tokyo, Japan).

Lin S.H., Cui W., Wang G.L., Meng S., Liu Y.C., Jin H.W., Zhang L.R, & Xie Y. (2016). Combined computational and experimental studies of molecular interactions of albuterol sulfate with bovine serum albumin for pulmonary drug nanoparticles. Drug Design, Development and Therapy, 10, 2973-2987.

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Characterization and Encapsulation Efficiency of Liposomes

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Transmission electronic microscopy (TEM, Tecnai G2 20ST, FEI Co., Tokyo, Japan) and atomic force microscopy (AFM, SPI3800N serie SPA-400, NSK Ltd., Tokyo, Japan) were used to characterize morphology of the liposomes. The particle size distribution, polydispersity and zeta potential of the liposomes were determined by a Nano Series Zen 4003 Zetasizer (Malvern Instruments Ltd., Malvern, UK).
For encapsulation efficiency measurement, 0.5 ml liposome suspension was passed through a Sephadex G-50 gel-filtration column, and the contents of daunorubicin and dihydroartemisinin were measured by a high-performance liquid chromatography (HPLC, Agilent Technologies Inc. Cotati, CA) at 233 and 210 nm, respectively. Mobile phase was acetonitrile to 0.02 mol/l sodium dihydrogen phosphate (32:68, volume ratio) for daunorubicin, and acetonitrile to water (60:40 volume ratio) for dihydroartemisinin, respectively. The encapsulation efficiency was calculated as follow: encapsulation efficiency % ¼ (A e /A total ) Â 100%, where A e represents the amount of encapsulated drug after eluting, and A total is the total amount of drug before eluting.

Ju R.J., Cheng L., Peng X.M., Wang T., Li C.Q., Song X.L., Liu S., Chao J.P, & Li X.T. (2018). Octreotide-modified liposomes containing daunorubicin and dihydroartemisinin for treatment of invasive breast cancer. Artificial cells, nanomedicine, and biotechnology, 46(sup1).

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