Recombinant human FGF2 protein (R&D systems, MN), PD173074 (Sigma Aldrich, MO), and anacardic acid (Abcam, Cambridge, UK) was used at appropriate concentrations. LY294002, U0126, SP600125, and SB203580 (Sigma Aldrich, MO) were used at 10 μM for experiments. Reparixin (Sigma Aldrich, MO) was used at 100 nM for experiments.
Reparixin
Manufactured by Merck Group
Sourced in Macao, United States
Reparixin is a laboratory product manufactured by Merck Group. It is a small-molecule compound that functions as a selective antagonist of the CXCR1 and CXCR2 chemokine receptors.
Automatically generated - may contain errors
Lab products found in correlation
Anacardic acid, by Abcam (1 mentions)
Sb203580, by Merck Group (1 mentions)
Sp600125, by Merck Group (1 mentions)
Pd173074, by Merck Group (1 mentions)
U0126, by Merck Group (1 mentions)
Ly294002, by Merck Group (1 mentions)
Gw2580, by Apexbio (1 mentions)
Ruxolitinib, by Adooq (1 mentions)
Vincristine sulfate, by Merck Group (1 mentions)
Oxaliplatin, by Merck Group (1 mentions)
Peg300, by Merck Group (1 mentions)
Dimethyl sulfoxide (dmso), by Merck Group (1 mentions)
Tween 80, by Daejung Chemicals (1 mentions)
3 protocols using reparixin
1
Modulating FGF2 Signaling Pathways
2
Tadpole Hormonal and Pharmacological Modulation
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Tadpoles were reared in water containing T3 (10 nM final concentration) or in water containing diluted solvent control (NaOH) alone for 5 days (21 (link)). During this time, subsets of animals also received daily intraperitoneal administration of a CSF-1R inhibitor (GW-2580; 100 mg/kg body weight (22 (link)); Apex Bio), a CXCR1/2 inhibitor (reparixin; 50 mg/kg body weight; Sigma) or vehicle control (18 (link)). The same injection sites were used for the daily drug administrations, and the water was changed daily for the 5-day duration of the experiments.
3
Preparation of Anticancer Drug Solutions
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Solutions of vincristine sulfate (Sigma Aldrich, St. Louis, MO, USA), oxaliplatin (Sigma Aldrich, St. Louis, MO, USA), reparixin (Sigma Aldrich, St. Louis, MO, USA), and ruxolitinib (Adooq Bioscience, Irvine, CA, USA) were prepared in 5% DMSO (Sigma Aldrich, St. Louis, MO, USA), 40% PEG300 (Sigma Aldrich, St. Louis, MO, USA), 5% tween 80 (Daejung Chemicals and Metals, Siheung-si, Republic of Korea), and 50% saline (Daihan Pharm, Seoul, Republic of Korea).
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