Gd hpdo3a

Manufactured by Bracco

Sourced in United Kingdom, Italy, United States

Gd-HPDO3A is a gadolinium-based contrast agent used in magnetic resonance imaging (MRI) procedures. It is designed to enhance the visibility of certain structures or tissues within the body during the imaging process.

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Lab products found in correlation

Prohance, by Bracco (2 mentions) Heparin, by Merck Group (1 mentions) Pen strep solution, by Lonza (1 mentions) Trypsine, by Lonza (1 mentions) Ficoll hystopaque, by Merck Group (1 mentions) Glutamine, by Lonza (1 mentions) Rpmi 1640 medium, by Lonza (1 mentions) Fetal bovine serum (fbs), by Lonza (1 mentions) Omniscan, by GE Healthcare (1 mentions) Magnetom avanto scanner, by Siemens (1 mentions)

Close spelling variants of this product

HPDO3A (2 citations) Gd-HPDO3A (Prohance) (2 citations)

5 protocols using gd hpdo3a

Preparation of Gd-HPDO3A and Gd-DOTP

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Gd-HPDO3A was kindly provided by Bracco Imaging S.p.A (Colleretto Giacosa, Torino, Italy). Gd-DOTP was synthesized as reported elsewhere. 43 Fetal Bovine Serum (FBS), Roswell Park Memorial Institute-1640 (RPMI-1640) medium, Glutamine, Pen/Strep solution and Trypsine were purchased from Lonza Group. Ficoll Hystopaque, heparin and all other chemicals were purchased from Sigma-Aldrich Co. LLC.

Di Gregorio E., Ferrauto G., Gianolio E., Lanzardo S., Carrera C., Fedeli F, & Aime S. (2015). An MRI Method To Map Tumor Hypoxia Using Red Blood Cells Loaded with a pO2-Responsive Gd-Agent. ACS nano, 9(8).

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Gd-based Contrast Agents Evaluation

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Two Gd-based contrast agents (GBCAs) were used for this study, namely Gadodiamide (Gd-DTPA-BMA, Omniscan 0.5 mol/L; GE Healthcare, Little Chalfont, UK ) and Gadoteridol (Gd-HPDO3A, ProHance 0.5 mol/L; Bracco Imaging, Milan, Italy ).

Di Gregorio E., Iani R., Ferrauto G., Nuzzi R., Aime S, & Gianolio E. (2018). Gd accumulation in tissues of healthy mice upon repeated administrations of Gadodiamide and Gadoteridol. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS), 48.

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Breast Cancer Xenograft Model in Mice

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Female nude mice (nu/nu Balb/c background, 4–6 weeks old) were purchased from Jackson Laboratories (Bar Harbor, Maine) and cared for in the Animal Core Facility at Case Western Reserve University (Cleveland, OH). All animal experiments were conducted in accordance with an approved protocol by the IACUC of CWRU. Mammary fat pads were injected with 2 x 10⁶ MDA-MB-231-GFP-Luc and 4 × 10⁶ Hs578T-GFP-Luc cells suspended in a matrigel-PBS mixture (1:1). Tumor volumes were monitored weekly using a Vernier caliper. Once the average tumor volume reached 70–90 mm³, mice were subjected to MR imaging (n = 5 for MT218 and n = 5 for Gd(HP-DO3A) (Bracco, Milan, Italy).

Ayat N.R., Vaidya A., Yeung G.A., Buford M.N., Hall R.C., Qiao P.L., Yu X, & Lu Z.R. (2019). Effective MR Molecular Imaging of Triple Negative Breast Cancer With an EDB-Fibronectin-Specific Contrast Agent at Reduced Doses. Frontiers in Oncology, 9, 1351.

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Euthanasia and Fixation Protocol for Marine Specimens

Cited 2 times

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Two male and one female adult specimens were collected off the Southern California coast by Aquatic Research Consultants (San Pedro, CA 90732, Fishes4Study.com, Chuck Winkler) and transported to USC the same day. Euthanasia was accomplished by immersion in a 1:3 mixture of isotonic magnesium chloride in artificial sea water. Specimen was maintained in this solution for at least 10 minutes after cessation of breathing, spontaneous behavior and motion of any kind before removing [55 (link), 56 (link)]. Specimen was transferred to 4% paraformaldehyde solution with stirring at 10℃ for several days for fixation. Samples were soaked in 2.5 mM Gadoteridol (Gd-HP-DO3A, Bracco Diagnostics Inc., Princeton, NJ) for 3 days. Samples were immersed in Galden (TMC Industries, MN) while being scanned.

, & Jacobs R.E. (2022). Diffusion MRI Connections in the Octopus Brain. Experimental Neurobiology, 31(1), 17-28.

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Multiparametric MRI for Prostate Cancer

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Routine clinical mpMRI acquisition includes T2W, DCE, and DWI. The DWI includes an apparent diffusion coefficient (ADC) map that was generated at the time of acquisition. Patients were injected with contrast agent Gadoteridol (Gd-HP-DO3A; ProHance, Bracco Diagnostics, Princeton, NJ, USA) with a dose of 0.1 mL/kg before MRI-DCE acquisition. All of the patients were imaged using MAGNETOM-Avanto scanner (Siemens Healthcare, Erlangen, Germany) scanner at 1.5 T with both endorectal coil and phase-array pelvic coil. Table 1 shows more details on the technical parameters of the MRI sequences.

Brancato V., Di Costanzo G., Basso L., Tramontano L., Puglia M., Ragozzino A, & Cavaliere C. (2020). Assessment of DCE Utility for PCa Diagnosis Using PI-RADS v2.1: Effects on Diagnostic Accuracy and Reproducibility. Diagnostics, 10(3), 164.

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