The biological data were generated from one single laboratory (Unilab, University Hospital of Liège, Belgium) accredited for ISO 15,189 guideline. Blood samples were collected during the afternoon, in a non-fasting status. Blood levels of albumin were assayed by spectrophotometry (Alinity C, Abbott, Chicago, IL, USA). Blood prealbumin and C-reactive protein concentrations were assayed using immunoturbidimetry (Alinity C, Abbott, Chicago, IL, USA). Blood levels of creatinine and triglycerides were assayed using an enzymatic assay (Alinity C, Abbott, Chicago, IL, USA). Blood levels of calcidiol (25OH-D) were measured using an immunoassay based on chemiluminescence (CLIA) (Liaison XL®, DiaSorin, Stillwater, MN, USA). The glomerular filtration rate was estimated using creatinine-based CKD-EPI equation.
Alinity c
Manufactured by Abbott
Sourced in United States
The Alinity C is an automated clinical chemistry analyzer designed for in vitro diagnostic testing. It is capable of performing a variety of biochemical assays to aid in the diagnosis and monitoring of various medical conditions.
Automatically generated - may contain errors
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24 protocols using alinity c
1
Biomarker Assessment of Nutritional Status
2
Nutritional Assessment in ICU Patients
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Demographic data (age, sex, actual weight, height, body mass index (BMI)) were recorded. Actual weight was used for patients with BMI < 25 kg/m2. Ideal body weight (IBW) was considered as the expected weight for BMI 25 in overweight patients. In obese patients (BMI ≥ 30), the adjusted body weight was calculated as follows: IBW + 0.33 × (actual weight-IBW) [11 (link)]. Data about the feeding regimen and ICU stay were also recorded.
The biological data were generated from one single laboratory (Unilab, CHU de Liège, Liège, Belgium) accredited by the ISO 15,189 Guideline. Blood levels of total protein were assayed using turbidimetry (Alinity C, Abbott, IL, USA); the reference range was 58–83 g/L. Blood levels of albumin were assayed by spectrophotometry (Alinity C, Abbott, IL, USA). The reference ranges for ≤60 years were 35–52 and for >60 years, 32–46 g/L. Blood prealbumin and C-reactive protein concentrations were assayed using immunoturbidimetry (Alinity C, Abbott, IL, USA). The reference ranges were 0.2–0.4 g/L and 0–5 mg/L.
The biological data were generated from one single laboratory (Unilab, CHU de Liège, Liège, Belgium) accredited by the ISO 15,189 Guideline. Blood levels of total protein were assayed using turbidimetry (Alinity C, Abbott, IL, USA); the reference range was 58–83 g/L. Blood levels of albumin were assayed by spectrophotometry (Alinity C, Abbott, IL, USA). The reference ranges for ≤60 years were 35–52 and for >60 years, 32–46 g/L. Blood prealbumin and C-reactive protein concentrations were assayed using immunoturbidimetry (Alinity C, Abbott, IL, USA). The reference ranges were 0.2–0.4 g/L and 0–5 mg/L.
3
Comprehensive Biomarker Assessment in Clinical Practice
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The urinary albumin concentration was determined on a Behring Nephelometer analyzer II (Siemens, Marburg, Germany) by immunonephelometry, and the total urinary protein concentration was measured by the pyrogallol method using a photometric assay on the Alinity c (Abbott, Chicago, IL, USA). Proteinuria was expressed as the total urinary protein concentration/the urinary creatinine concentration ratio. The urinary creatinine concentration was detected by an alkaline picrate assay using the Cobas c 701 (Roche, Basel, Switzerland). The hemoglobin concentration was measured with a Sysmex XE-5000 (Sysmex Europe GmbH, Norderstedt, Germany). HbA1c was analyzed by ion exchange chromatography on the Tosoh HLV-723 G8 (Tosoh, Tokyo, Japan). C-reactive protein (CRP) and serum creatinine were determined by a photometric assay on an Alinity c (Abbott Laboratories, Chicago, IL, USA). The estimated glomerular filtration rate (eGFR) was calculated with the chronic kidney disease epidemiology collaboration (CKD-EPI) formula [21 (link)]. Serum total cholesterol, high-density lipoprotein (HDL)-cholesterol and triglyceride levels were measured using a photometric assay on an Alinity c (Abbott Laboratories, Chicago, IL, USA). Low-density lipoprotein (LDL)-cholesterol values were derived using the Friedewald formula [22 (link)].
4
Blood Markers and Muscle Catabolism in ICU
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Demographic data and data related to the ICU stay were retrospectively extracted from medical charts.
The following blood markers were also collected prospectively at the two timepoints: blood white cell count (Sysmex XN Series, Norderstedt, Germany), C-reactive protein (CRP), albumin, prealbumin, triglycerides, urea, enzymatic creatinine (Alinity C, Abbott, Lake Bluff, IL, USA) and cystatin C (Cobas, Roche, Mannheim, Germany). The glomerular filtration rate (eGFR) was estimated using the creatinine-based CKD-EPI equation. The ratio of serum urea/creatinine was calculated: an elevated ratio reflects muscle catabolism [18 (link)]. The Sarcopenia Index was defined as [(serum creatinine/serum cystatin C) × 100], with a low index reflecting a reduced muscle mass [19 (link)].
The following blood markers were also collected prospectively at the two timepoints: blood white cell count (Sysmex XN Series, Norderstedt, Germany), C-reactive protein (CRP), albumin, prealbumin, triglycerides, urea, enzymatic creatinine (Alinity C, Abbott, Lake Bluff, IL, USA) and cystatin C (Cobas, Roche, Mannheim, Germany). The glomerular filtration rate (eGFR) was estimated using the creatinine-based CKD-EPI equation. The ratio of serum urea/creatinine was calculated: an elevated ratio reflects muscle catabolism [18 (link)]. The Sarcopenia Index was defined as [(serum creatinine/serum cystatin C) × 100], with a low index reflecting a reduced muscle mass [19 (link)].
5
Biomarker Analysis in Sepsis Diagnosis
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Complete blood counts (CBCs) were performed on whole blood by Sysmex XE-9000 (Dasit, Italy) following the manufacturer’s instruction. NLR, PLR, and MLR were calculated by the ratio between absolute values of neutrophils, lymphocytes, monocytes, respectively, and that of platelets.
CRP protein was measured by Alinity c (Abbott, diagnostics) following the manufacturer’s instruction.
PCT and MR-proADM plasma concentrations were measured by an automated Kryptor analyzer, using a time-resolved amplified cryptate emission (TRACE) technology assay (Kryptor PCT; Brahms AG; Hennigsdorf, Germany) with commercially available immunoluminometric assays (Brahms) [5 (link),21 (link),25 (link),26 (link)].
Blood specimens from patients were collected in BACTEC bottles containing anaerobic or aerobic broth and resins. Blood culture bottles were incubated in BACTEC FX instrument (Becton Dickinson, Meylan, France) until they were positive for bacterial growth or for a maximum of 5 days. Positive samples were cultivated in selective agar media. Growing colonies were identified by MALDI-TOF (Brahms) [5 (link),21 (link),25 (link),26 (link)]. Selective and non-selective media were used for microbiological cultures.
CRP protein was measured by Alinity c (Abbott, diagnostics) following the manufacturer’s instruction.
PCT and MR-proADM plasma concentrations were measured by an automated Kryptor analyzer, using a time-resolved amplified cryptate emission (TRACE) technology assay (Kryptor PCT; Brahms AG; Hennigsdorf, Germany) with commercially available immunoluminometric assays (Brahms) [5 (link),21 (link),25 (link),26 (link)].
Blood specimens from patients were collected in BACTEC bottles containing anaerobic or aerobic broth and resins. Blood culture bottles were incubated in BACTEC FX instrument (Becton Dickinson, Meylan, France) until they were positive for bacterial growth or for a maximum of 5 days. Positive samples were cultivated in selective agar media. Growing colonies were identified by MALDI-TOF (Brahms) [5 (link),21 (link),25 (link),26 (link)]. Selective and non-selective media were used for microbiological cultures.
6
Defining Acute Kidney Injury Using KDIGO Criteria
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AKI was defined using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria based on a 1.5-fold increase in serum creatinine on enrollment from the estimated baseline. AKI was staged as follows: stage 1, 1.5–1.9-fold increase in creatinine over baseline; stage 2, 2.0–2.9-fold increase over baseline; and stage 3, ≥ 3.0-fold increase over baseline. AKI was classified as severe (severe AKI) if it was stage 2 or 3 [21 (link)]. Baseline creatinine was estimated using a previously validated height-independent approach assuming a GFR of 120 mL/min per 1.73m2 as previously described [22 (link)]. The eGFR value was adjusted for the difference between estimated and measured GFR values by age using iohexol clearance. Adding a constant value of 16 to age-based norms across age groups was used to account for creatinine-based over-estimation of GFR [23 (link)]. Creatinine was tested using the modified Jaffe colorimetric method on an Alinity c instrument (Abbott, Lake Forest, IL) which is traceable to an isotope dilution mass spectrometry (IDMS) reference method.
7
Thyroid and Kidney Function Assessment
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TSH, fT4, fT3, TPOAb, and TgAb concentrations in serum were determined in Central Clinical Laboratory in Gdansk using the chemiluminescent microparticle immunoassay (CMIA) method (Alinity I Abbott Laboratories Poland). Moreover, serum creatinine concentration has been measured by the spectrophotometric method (Alinity C Abbott Laboratories Poland). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) eGFR has been calculated based on the creatinine concentration.
8
Retrospective Analysis of Pancreaticoduodenectomy Outcomes
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From a prospective maintained database, data of consecutive patients who underwent PDs between January 2012 and January 2020 at the Department of General Surgery of the Campus Bio-Medico University of Rome, Italy, have been retrospectively analyzed.
The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The local Ethical Committee approved the study (28/19 OSS ComEt CBM). Patient consent was waived due to the retrospective design of the study and considering that data are de-identified.
Demographic characteristics (age, sex, etc.), site and histological type of all tumors were collected. All patients underwent Whipple or Traverso-Longmire PD based on tumor location and received a single layer duct-to-mucosa pancreato-jejunal reconstruction. At the end of the procedure, two Jackson-Pratt abdominal drains were placed. Details of surgical procedures have been previously described (17 (link)).
Postoperative PCT and drains amylase levels concentration were measured on Alinity C and Alinity I Autoanalyzers (Abbott Park, Illinois, USA) with commercially available chemilumescence kit and immunoassays (Abbott Park, Illinois, USA). POPF was defined according to the criteria of the International Study Group of Pancreatic Surgery (3 (link),4 (link)). The exclusion criteria are described inFigure 1 .
The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The local Ethical Committee approved the study (28/19 OSS ComEt CBM). Patient consent was waived due to the retrospective design of the study and considering that data are de-identified.
Demographic characteristics (age, sex, etc.), site and histological type of all tumors were collected. All patients underwent Whipple or Traverso-Longmire PD based on tumor location and received a single layer duct-to-mucosa pancreato-jejunal reconstruction. At the end of the procedure, two Jackson-Pratt abdominal drains were placed. Details of surgical procedures have been previously described (17 (link)).
Postoperative PCT and drains amylase levels concentration were measured on Alinity C and Alinity I Autoanalyzers (Abbott Park, Illinois, USA) with commercially available chemilumescence kit and immunoassays (Abbott Park, Illinois, USA). POPF was defined according to the criteria of the International Study Group of Pancreatic Surgery (3 (link),4 (link)). The exclusion criteria are described in
9
Cardiovascular Biomarker Profiling
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Blood samples were obtained on admission before cardiac catheterization. Blood cell count, glucose, creatinine, high-sensitivity troponin I (hs-TnI), procalcitonin (PCT) and lipid profile were measured using routine laboratory techniques. The blood count was measured by a Siemens high volume hematology analyzer ADVIA 2120i. A sodium citrate tube and ACL TOP 500 analyzer were used for quantitative D-dimer measurement. High-sensitivity C-reactive protein (hsCRP) was measured quantitatively by immunoturbidimetric assay (Abbott Alinity C, Illinois, U.S.A.).
10
Glucose Measurement in Admission Samples
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Glucose was measured in random samples collected at the time of admission by an enzymatic method in the biochemistry automated analyzer Alinity C (Abbott Laboratories, Illinois, USA).
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