Epo a

Manufactured by Merck Group

Sourced in United States

EPO-A is a laboratory equipment product manufactured by Merck Group. It is designed for use in scientific research and analysis. The core function of EPO-A is to assist in the separation and purification of erythropoietin (EPO) proteins from biological samples.

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Lab products found in correlation

Anti cancer compound library, by Selleck Chemicals (1 mentions) Sitagliptin, by Merck Group (1 mentions) Fetal bovine serum (fbs), by Cambrex (1 mentions) Penicillin, by Merck Group (1 mentions) Streptomycin, by Merck Group (1 mentions) Trypsin edta, by Merck Group (1 mentions) Metformin, by Merck Group (1 mentions) Sodium salicylate, by Merck Group (1 mentions)

2 protocols using epo a

Anti-cancer Compound Library Screening

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We used the “Anti-cancer Compound Library” (L3000, Selleckchem Inc., Houston, TX, USA) consisting of 349 compounds all in use or under clinical trial. After the library screenings, VCR was purchased from Pfizer Inc. (New York, NY, USA) as a 1 mg/ml solution, while EPO-A was purchased from Sigma-Aldrich, St. Louis, MO, USA and dissolved in DMSO at a 100 μM concentration. Data for each single compound were reported as percent inhibition toward solvent-treated cells (100%).
SI113 was synthesized as previously reported [40 (link)]. The drug was diluted in DMSO at a 50 mM concentration.

Abbruzzese C., Catalogna G., Gallo E., di Martino S., Mileo A.M., Carosi M., Dattilo V., Schenone S., Musumeci F., Lavia P., Perrotti N., Amato R, & Paggi M.G. (2017). The small molecule SI113 synergizes with mitotic spindle poisons in arresting the growth of human glioblastoma multiforme. Oncotarget, 8(67), 110743-110755.

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Examining Cellular Responses to Pharmaceutical Compounds

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Drugs: EpoA, metformin and sitagliptin were obtained from Sigma Aldrich (St. Louis, USA). Pifithirin-α (PFT-α, p53 inhibitor), sodium salicylate (SSA, an NF-κB inhibitor) were also purchased from Sigma Aldrich. NF-κBp65, Membrane Permeability/Dead Cell Apoptosis Kit were purchased from Invitrogen (Camarillo, USA), Human p53 ELISA Kit was from Dialcone (Besancon Cedex, France).
Solvents and chemicals for cell culture: medium (DMEM) and fetal bovine serum (FBS) were obtained from Cambrex (Basel, Switzerland); trypsin-EDTA, penicillin and streptomycin were acquired from Sigma Aldrich (St. Louis, USA).

Rogalska A., Sliwinska A., Kasznicki J., Drzewoski J, & Marczak A. (2016). Effects of Epothilone A in Combination with the Antidiabetic Drugs Metformin and Sitagliptin in HepG2 Human Hepatocellular Cancer Cells: Role of Transcriptional Factors NF-κB and p53. Asian Pacific journal of cancer prevention : APJCP, 17(3).

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