Brain imaging data were acquired on a 3T Discovery MR750w scanner (General Electric) using a 32-channel head coil at the National Centre for Sport and Exercise Medicine, Loughborough University, United Kingdom. Structural images (T1-weighted) were acquired using a fast spoiled gradient echo (FSPGR) Bravo sequence (3D volume, FSPGR; TR=8.2 ms; TE=3.1 ms; matrix size 240×240; 160 sagittal slices; FOV=240 mm; 1 mm thick). One functional scan lasting 16 minutes (480 volumes) was acquired during the task (2D gradient echo EPI; TR=2000 ms; TE=30 ms; flip angle=75 degrees; matrix size 64×64; 35 axial slices; FOV=205 mm; 3 mm thick). Stimulus presentation and synchronization to scanner acquisition were performed using Presentation version 18.1 (Neurobehavioral Systems Inc).
3t discovery mr750w scanner
Manufactured by GE Healthcare
Sourced in United States
The 3T Discovery MR750w scanner is a magnetic resonance imaging (MRI) system designed by GE Healthcare. It operates at a magnetic field strength of 3 Tesla, providing high-resolution images for diagnostic and research purposes. The system features a wide-bore design and advanced imaging capabilities.
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4 protocols using 3t discovery mr750w scanner
1
Functional Neuroimaging of Brain Activity
2
Dynamic Contrast-Enhanced MRI of Cortical Porosity
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Cortical pore content was assessed by DCE-MRI (Wu et al., 2019 (link)) performed on a clinical 3 T Discovery MR750w scanner (GE Healthcare, Waukesha, WI, USA) using a sixteen-channel flex coil (In-Vivo Corporation, Gainesville, FL, USA). Scan field-of-view (FOV) covered the ultra-distal HR-pQCT scan location, which centered 34.5 mm proximal from the tibiotarsal joint line. A 3D scan time series was acquired over 9 min using a spoiled gradient-recalled (SPGR) sequence with circular cartesian under sampling (CIRCUS) for increased temporal resolution of 30 s (TR/TE 11.8–12.2 ms/4.1 ms, bandwidth ±125 kHz, flip angle 20°, FOV 12 × 9 cm2, matrix size 512 × 384, in-plane resolution 230 × 230 μm2, and total of 56 slices with thickness of 500 μm) (Liu et al., 2016 (link)). Intravenous gadolinium-based contrast agent (Gadavist, Bayer Healthcare, Whippany, NJ, USA) was injected with a volume adapted to body weight (0.1 ml/kg) at a flow rate of 2 ml/s and 1 min delay after the start of the acquisition.
3
Stroke Evaluation MRI Protocol
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MRI scans were acquired at the time of clinical evaluations (24-72 hours and 1 year after stroke) by using a 3T Discovery MR 750w scanner (GE Medical System, Milwaukee, WI) with a 32-channel phasedarray head coil. The imaging protocol included a DTI sequence using dual echo-planar imaging (40 axial slices; repetition time: 15 000 ms; echo time set to minimum; slice thickness: 3.5 mm; matrix: 160×160; field of view: 24 cm 2 ; b values: 0 and 1000 s/mm 2 applied in 16 noncolinear directions; scan time: 4 minutes and 30 seconds).
4
Pediatric Neuroimaging Protocol on 3T MRI
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An overview of the imaging procedure, sequences, and quality assessment has been described previously (17) and can be found in the Supplement. Every child was invited to participate in a mock scanning session before the MRI scan to familiarize them with the procedure. If at any point the child was too anxious about the procedure, he or she did not progress to the MRI scan. All images were acquired on a 3T Discovery MR750W scanner (GE Healthcare, Chicago, IL) using an eightchannel head coil.
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