Alugram sil g7uv254 sheets

The NMR spectra (¹H and ¹³C) were recorded on a Bruker 400 Ultrashield^TM spectrometer (Rheinstetten, Germany) and are provided in the supplementary material. The samples were solved in CDCl₃ and TMS was used as an internal standard. IR spectra were obtained on a Thermo Nicolet FT-IR Nexus spectrophotometer (Thermo Nicolet, Madison, WI, USA) using KBr pellets for solids or NaCl plates for oil compounds. The HRMS spectra were recorded on a Thermo Scientific Q Exactive Focus mass spectrometer (Thermo Scientific™, Waltham, MA, USA) by direct infusion. For TLC assays, Alugram SIL G7UV254 sheets (Macherey-Nagel; Düren, Germany) were used. Column chromatography was performed with silica gel 60 (E. Merck KGaA, Darmstadt, Germany). Chemicals were purchased from E. Merck KGaA (Darmstadt, Germany), Panreac Química S.A. (Montcada i Reixac, Barcelona, Spain), Sigma-Aldrich Quimica, S.A. (Alcobendas, Madrid, Spain), and Acros Organics (Janssen Pharmaceuticalaan, Geel, Belgium).

Melting points (m.p.) were determined with a FP82 + FP80 apparatus (Mettler, Greifensee, Switzerland). The NMR spectra (¹H/400 MHz and ¹³C/100 MHz, Supplementary Materials) were recorded on a Ultrashield^TM 400 spectrometer (Bruker, Rheinstetten, Germany). The samples were dissolved in DMSO-d₆ or CDCl₃ and TMS was used as internal standard. IR spectra were obtained on a FT-IR Nexus spectrophotometer (Thermo Nicolet, Madison, WI, USA) using KBr pellets for solids or NaCl plates for oil compounds. Elemental analysis was performed on a CHN-900 Elemental Analyzer (LECO, Saint Joseph, MI, USA). HRMS were recorded using an Accurate-Mass TOF LC/MS 6220 (Agilent Technologies, Santa Clara, CA, USA). Only data from compounds 3, 9, 10, 12 and 13 could be obtained due to poor volatilization of the remaining compounds. For TLC assays, Alugram SIL G7UV254 sheets (Macherey-Nagel; Düren, Germany) were used. Column chromatography was performed with silica gel 60 (Merck, Darmstadt, Germany). Chemicals were purchased from E. Merck, Panreac Química S.A. (Montcada i Reixac, Barcelona, Spain), Sigma-Aldrich Quimica, S.A. (Madrid, Spain) and Acros Organics (Janssen Pharmaceuticalaan, Geel, Belgium).