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Fin56

Manufactured by Targetmol
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Sourced in United States

FIN56 is a small molecule that inhibits ferroptosis, a form of regulated cell death. It functions by regulating the activity of enzymes involved in lipid peroxidation, a key process in ferroptosis.

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Lab products found in correlation

Erastin, by Targetmol (1 mentions) Am251, by Targetmol (1 mentions) Ml 210, by Targetmol (1 mentions) Ly294002, by Targetmol (1 mentions) Pd98059, by Targetmol (1 mentions) Cisplatin, by Targetmol (1 mentions) Deferoxamine mesylate, by Targetmol (1 mentions) Necrosulfonamide, by Targetmol (1 mentions) Ferrostatin 1, by Targetmol (1 mentions) Z vad ome fmk, by Targetmol (1 mentions) L citrulline, by Sangon (1 mentions) L proline, by Sangon (1 mentions) L arginine, by Sangon (1 mentions)

2 protocols using fin56

1

Screening Small-Molecule Inhibitors in Cell Lines

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The small-molecule inhibitors were all purchased from Targetmol, Wellesley Hills, MA, USA including Lipid metabolism compounds library (L2510), CB1 antagonists (AM251, T1915; AM281, T2264; JD5037, T4453; Otenabant, T3530; TM3837, T8511; CB1-IN-1, T5996), ferroptosis inducers (erastin, T1765; RSL3, T3646; ML-210, T8375; FIN56, T4066; CIL56, T4309), PI3K inhibitor (LY294002, T2008) and MEK inhibitor (PD98059, T2623).
Li P., Lin Q., Sun S., Yang N., Xia Y., Cao S., Zhang W., Li Q., Guo H., Zhu M., Wang Y., Zheng Z, & Li S. (2022). Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism. Cell Death & Disease, 13(9), 808.
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2

Ferroptosis and Cell Death Modulators

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The following compounds were obtained from TargetMol (USA): RSL3 (T3646), IKE (T5523), ferrostatin-1 (T6500), deferoxamine mesylate (T1637), Z-VAD (OMe)-FMK (T6013), necrosulfonamide (T7129), FIN56 (T4066), FINO2 (T60084), LF3 (T7399), SKL2001 (T6989), cisplatin (T1564), aminoguanidine hydrochloride (T0358). The following compounds were obtained from MedChemExpress (MCE, USA): AMXT-1501 (HY-124617A), DFMO (HY-B0744), GC7 (HY-108314A). The following compounds were obtained from Sangon Biotech (China): l-arginine (A600205), l-citrulline (A604057L), l-proline (A600923), putrescine dihydrochloride (A600793). The following compounds were obtained from Aladdin (China): L-ornithine monohydrochloride (O108803), urea (A610148), spermidine (S107071), spermine (S109704), ammonium ferric citrate (A100170).
Bi G., Liang J., Bian Y., Shan G., Huang Y., Lu T., Zhang H., Jin X., Chen Z., Zhao M., Fan H., Wang Q., Gan B, & Zhan C. (2024). Polyamine-mediated ferroptosis amplification acts as a targetable vulnerability in cancer. Nature Communications, 15, 2461.
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