Lh750

Manufactured by Beckman Coulter

Sourced in United States

The LH750 is a hematology analyzer designed for clinical laboratory use. It provides automated analysis of complete blood count (CBC) parameters, including red blood cells, white blood cells, and platelets. The core function of the LH750 is to perform rapid and accurate blood cell counting and differentiation for diagnostic purposes.

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Lab products found in correlation

Au5800, by Beckman Coulter (11 mentions) Architect c16000 analyzer, by Abbott (4 mentions) Advia centaur xp, by Siemens (1 mentions) Immunoturbidimetric assay, by Fujifilm (1 mentions) Canto 2, by BD (1 mentions) C16000, by Abbott (1 mentions) Cobase e601, by Roche (1 mentions) Particle enhanced immunonephelometric assay, by Siemens (1 mentions) Turbidimetric immunoassay, by Hitachi (1 mentions) Cobas c311 analyzer, by Roche (1 mentions) Lx20 pro, by Beckman Coulter (1 mentions) Cobas integra 800, by Roche (1 mentions) Accuri c6 system, by BD (1 mentions) Dxh 800, by Beckman Coulter (1 mentions) Ie33 ultrasound machine, by Philips (1 mentions) Dc800, by Beckman Coulter (1 mentions) Toledo delta 320 ph meter, by Mettler Toledo (1 mentions) Facscalibur, by BD (1 mentions) Cd3 allophycocyanin, by BD (1 mentions) Cd4 fluorescein isothiocyanate, by BD (1 mentions)

Close spelling variants of this product

LH750 Haematology Analyser (6 citations) LH750/780 (3 citations) LH750 Blood Cell Analyzer (3 citations) Hematology Analyzer LH750 (3 citations)

94 protocols using lh750

Portable μLow Cytometer Leukocyte Enumeration

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Example 3

FIG. 5 shows an example of the results of enumerating total number of leukocyte. The results marked as “The portable μLow Cytometer” are results measured with the present method, and the results marked as “Commercial Hematology Analyzer” are results measured with a commercial Hematology Analyzer (Beckman Coulter LH750). S1, S2, S3, S4, S5, S6, S7 represents samples 1-7.

FIG. 6 shows an example of the differential result of classifying different types of leukocytes. The percentage means the percentage of one specific type of leukocyte, such as lymphocyte, monocyte, neutrophil or eosinophil, among the total number of leukocytes. The results marked as “μLow Cytometer” are results measured with the present method, and the results marked as “Commercial Hematology Analyzer” are results measured with a commercial Hematology Analyzer (Beckman Coulter LH750).

All publications and patents cited in this specification are incorporated herein by reference herein. While the invention has been described with reference to a particularly preferred embodiment, it will be appreciated that modifications can be made without departing from the spirit of the invention. Such modifications are intended to fall within the scope of the appended claims.

US10371640B2. Compositions and methods for leukocyte differential counting (2019-08-06). CALIFORNIA INSTITUTE OF TECHNOLOGY [US]. Inventors: Yu-Chong Tai [US], Wendian Shi [US], Harvey Kasdan [IL].

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Prognostic Factors in Oncology Patients

Cited 1 time

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The peripheral venous blood was collected in fasting state within one week before chemotherapy in all patients. The counts of peripheral neutrophils, lymphocytes, and platelets were measured and analyzed by an automatic blood analyzer (Beckman Coulter LH750), and the levels of peripheral albumin were measured and analyzed by an automatic blood analyzer (Beckman Coulter AU5800). The definitions of PNI and SII were shown as follows: PNI= albumin (g/L) + 5×total lymphocyte counts(10⁹/L) (26 (link)); SII= platelet × neutrophil/lymphocyte counts (27 (link)).
All patients were recommended to have a follow-up visit every 3 months in the first 2 years, and every 6 months after 2 years. Follow-up methods mainly include telephone encounter, outpatient visits, and hospitalization. The hospital examination items included CT of chest, abdomen, and pelvis, as well as esophagogastroduodenoscopy (EGD) and tumor markers. In this study, the deadline for follow-up was September, 1^st, 2021. Overall survival (OS) was defined as the time interval from treatment to cancer-related death or final contact, and OS was the preferred destination. And progression-free survival (PFS) was measured from the time of treatment initiation to clinical or radiographic progression or death from any cause.

Ding P., Yang P., Sun C., Tian Y., Guo H., Liu Y., Li Y, & Zhao Q. (2022). Predictive Effect of Systemic Immune-Inflammation Index Combined With Prognostic Nutrition Index Score on Efficacy and Prognosis of Neoadjuvant Intraperitoneal and Systemic Paclitaxel Combined With Apatinib Conversion Therapy in Gastric Cancer Patients With Positive Peritoneal Lavage Cytology: A Prospective Study. Frontiers in Oncology, 11, 791912.

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Biomarker Profiling in Gallbladder Cancer

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Peripheral blood samples were obtained from newly diagnosed patients with GBC. Blood samples of all cases for hemogram were analyzed with Beckman Coulter LH-750/Sysmax XN-1000 coulter as per our laboratory protocol. Normal RDW levels are 11.5–14.5. Serum levels of CEA, CA 19-9, and CA 125 were measured using Advia Centaur XP, Siemens chemiluminescence method. According to the manufacturer's instructions, cutoff value for normal CEA is <5 ng/mL, CA 19-9 is <37 U/mL, and CA 125 is 0–35 U/L.

Gupta A., Gupta S., Gupta A., Gupta A., Goyal B., Agrawal S., Joshua L.M., Kumar U., Ravi B, & Kant R. (2019). Red Cell Distribution Width: A Surrogate Biomarker to Predict Tumor Burden in Carcinoma Gallbladder. Nigerian Journal of Surgery : Official Publication of the Nigerian Surgical Research Society, 25(2), 198-202.

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Resting Plasma Volume Change Measurement

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Prior to HA exercise on day 1 and day 10, subjects were seated for 20 min in a cool room.²⁷ (link) Then 10 mL of venous blood was drawn from an antecubital vein for the determination of hemoglobin (Hb) and hematocrit (Hct). The Hct was determined in triplicate by centrifuging 3 heparinized capillary tubes (Model C-MH30, Unico, Dayton, NJ) at 12,000 rpm for 5 min and Hb was measured by Quest Diagnostics (Albuquerque, NM) using established procedures (Beckman Coulter, LH750). The Hct, corrected by 0.96 for trapped plasma, and Hb values were used to calculate resting ΔPV from day 1 to day 10.²⁸ (link)

White A.C., Salgado R.M., Astorino T.A., Loeppky J.A., Schneider S.M., McCormick J.J., McLain T.A., Kravitz L, & Mermier C.M. (2015). The effect of 10 days of heat acclimation on exercise performance in acute hypobaric hypoxia (4350 m). Temperature: Multidisciplinary Biomedical Journal, 3(1), 176-185.

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Lipid Profile and Blood Cell Analysis

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The blood samples were collected from each patient on the next day after admission. Plasma Lp(a) levels were measured using an immunoturbidimetric assay (Wako Chemicals USA, Inc. Richmond, VA) with a Hitachi 912 autoanalyzer (Roche Diagnostics, Basel, Switzerland). Meanwhile, the levels of plasma total cholesterol, total triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), plasma glucose, and serum creatinine were analyzed by the automatic biochemical analyzer. Blood cell tests were executed using an automated blood cell counter (Beckman Coulter LH750, CA, USA). Laboratory test results were generated by personnel blinded to the clinical characteristics of the study participants.

Wang Y., Ma H., Yang J., Chen Q., Lu L, & Zhang R. (2016). Lipoprotein(a) is associated with left ventricular systolic dysfunction in a Chinese population of patients with hypertension and without coronary artery disease. Archives of Medical Science : AMS, 13(5), 1078-1085.

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Comprehensive Immunological Profiling

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The relevant indicators of the patients were observed. All indicators were detected using the corresponding instruments and matching kits. Serum albumin (ALB), serum creatinine (SCr), and endogenous creatinine clearance (Ccr), as well as IgA, IgG, IgM, and complement C3 and C4 levels, were measured using an automated biochemical analyzer (Abbott C16000). A Beckman whole blood cell analyzer (LH750) was used to detect white blood cells (WBC), platelets (PLT), neutrophils (NEU), lymphocytes (LYM), and monocytes (MON). The peripheral blood was tested with flow cytometry (BD Canto II) for the detection of CD3 + T, CD3 + CD4 + T, CD3 + CD8 + T, CD19 + B, and NK subsets.

Deng Y., Ou Y.Y., Mo C.J., Huang L., Qin X, & Li S. (2023). Peripheral blood lymphocyte subsets in children with nephrotic syndrome: a retrospective analysis. BMC Nephrology, 24, 7.

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Prognostic Markers in Chemotherapy Patients

Cited 2 times

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Peripheral venous blood samples were collected in fasting state within 1 week before initiation of chemotherapy in all patients. Peripheral neutrophil, lymphocyte and platelet counts were measured and analysed using an automated haematology analyser (Beckman Coulter LH750) and albumin levels were measured and analysed using an automated haematology analyser (Beckman Coulter AU5800), respectively. Referring to the results in our previous studies, in this study PNI was defined as PNI = albumin (g/L) + 5 × total lymphocyte count (10⁹/L) and SII was defined as SII = platelets × neutrophil/lymphocyte count [28 (link), 29 (link)].
All patients were recommended to have an enhanced CT scan of the abdomen every 3 months for the first 3 years postoperatively and every 6 months for the 4–5th years. Follow-up methods mainly included telephone encounter, outpatient visits, and hospitalization. In this study, our primary observational endpoint was recurrence-free survival (RFS), defined as the time from the start of neoadjuvant therapy to the date of documented relapse or death from any cause at follow-up, and the follow-up deadline date for this study was January 31, 2022.

Ding P., Wu J., Wu H., Sun C., Guo H., Lowe S., Yang P., Tian Y., Liu Y., Meng L, & Zhao Q. (2023). Inflammation and nutritional status indicators as prognostic indicators for patients with locally advanced gastrointestinal stromal tumors treated with neoadjuvant imatinib. BMC Gastroenterology, 23, 23.

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Thalassemia Genetic Profiling Protocol

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Fasting venous blood samples were drawn by sterile venipuncture. Samples from patients receiving blood transfusion were drawn before transfusion of packed red blood cells. The hematologic analysis was performed using an automated blood cell analyzer (LH750 Beckman, USA). The SF levels were measured using an electro-chemiluminescence immunoassay (COBASE E601, Roche, USA), and the levels of hemoglobins, HbA, HbA2 and HbF were determined using the Bio-Rad Variant II high-performance liquid chromatography system. All patients were genotyped by the Shenzhen Huada Gene Medical Institute for 338 known mutations linked to α- or β-thalassemia.

Huang Y., Lei Y., Liu R., Liu J., Yang G., Xiang Z., Liang Y, & Lai Y. (2019). Imbalance of erythropoiesis and iron metabolism in patients with thalassemia. International Journal of Medical Sciences, 16(2), 302-310.

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Seasonal Variations in Biomarker Levels

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At two separate visits (2006–2010 and 2012–2013),
plasma samples were collected in 4mL EDTA vacutainers and analyzed within 24
hours of sampling utilizing four Beckman Coulter LH750 instruments (Sheard
et al., 2017). Serum samples were analyzed for levels of vitamin D (nmol/L)
and 24 other biomarkers, as listed in Text S1. All serum biomarkers
were tested in a backwards elimination approach to reduce bias (see
statistical analysis section). Vitamin D serum levels were corrected for
seasonal effects based on the time of the year. The serum samples were
collected in spring, summer, autumn, or winter.

Klinedinst B.S., Meier N.F., Larsen B., Wang Y., Yu S., Mochel J.P., Le S., Wolf T., Pollpeter A., Pappas C., Wang Q., Allenspach K., Wang L., Russell D., Bennett D.A, & Willette A.A. (2020). Walking in the light: How history of physical activity, sunlight, and vitamin D account for body fat - a UK Biobank study. Obesity (Silver Spring, Md.), 28(8), 1428-1437.

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Hematological Markers in Sepsis Diagnosis

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Hemogram and VCS parameters of 134 proven blood culture-positive cases of sepsis were reviewed on the day of culture positivity (day 0), day 3, and day 7 were analyzed. Samples were processed in hematology analyzer LH 750 (Beckman Coulter, Fullerton, CA, USA) within 4 h after receiving in the laboratory. The patient's medical records were also reviewed for clinical correlation. Patients with any known hematological disorder or malignancy, patients on multivitamins/hematinics, and patients with burns/trauma or those with macrocytosis (MCV >110 FL) on day 0 were excluded from the study.

Arora P., Gupta P.K., Lingaiah R, & Mukhopadhyay A.K. (2019). Volume, conductivity, and scatter parameters of leukocytes as early markers of sepsis and treatment response. Journal of Laboratory Physicians, 11(1), 29-33.

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