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Rapid stimulator

Manufactured by Magstim
Sourced in United Kingdom

The Magstim Rapid stimulator is a medical device designed for transcranial magnetic stimulation (TMS) applications. It generates short, high-intensity magnetic pulses to stimulate specific areas of the brain. The core function of the Magstim Rapid stimulator is to provide a safe and controlled method of applying TMS for research and clinical purposes.

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16 protocols using rapid stimulator

1

Transcranial Magnetic Stimulation with H1-coil

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The treatment was given using a Magstim Rapid stimulator (Magstim Company, Ltd, Carmarthenshire, Wales, UK) with an H1-coil (Brainsway Inc., Jerusalem, Israel).
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2

Repetitive TMS for Schizophrenia Treatment

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The samples were from two randomized, blinded, controlled trials. The duration of rTMS treatment was 4 weeks for a total of 20 sessions. A computer program was used to generate a random number list. Patients with SCZ were assigned to either the active 10 Hz rTMS group or the sham group according to the randomized sequence. Researchers, patients, and raters remained blinded to the trial grouping throughout the trial.
Neuronavigation rTMS was administrated with the MagStim Rapid Stimulator as the protocols described in our previous studies33 (link),34 (link). Each patient was treated on the left DLPFC once a day, five times a week, for a total of four consecutive weeks [23]. Patients in the sham group received the same study procedures as 10 Hz stimulation, except that the sham coil (P/N:3910-00) looked identical to the active coil and patients could not distinguish whether they were assigned to the 10 Hz group or the sham group. The stimulations over left DLPFC occurred at a power of 110% of MT35 (link).
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3

Determining Phosphene Thresholds via TMS

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Subjects were requested to fixate a crosshairs in front of them while seated in a semi-darkened room with their head fixed on a chinrest. Single biphasic TMS pulses were administered using a figure-of-eight shaped coil with the handle orientated upwards, attached on a tripod and placed 1–5 cm above the inion (coil: outside diameter 8.7 cm, peak magnetic field strength 2.2 T, peak electric field strength 660 V/m) using a Magstim Rapid stimulator (Magstim, Whitland, Dyfed, UK). First, we tried to generate phosphenes by starting with 80% of maximal stimulator output and raising the output in increments of 5% until a stable phosphene was perceived. Secondly, we determined the PT (Sparing et al., 2002 (link)). We started with 30% and increased the output in 5%-steps until phosphenes were reported. To confirm and refine the PT, we increased and decreased the output in a randomized order around the supposed threshold. The exact PT was defined as the minimum stimulus intensity of stimulator output able to evoke phosphene perception in at least three of five repetitions at the same output.
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4

Transcranial Magnetic Stimulation of Motor Cortex

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Magnetic stimulation was applied to the left motor area M1 by means of a Magstim Rapid stimulator and a flat alpha coil (D70 Alpha Flat Coil, Magstim Company, Whitland, Dyfed, UK) being held by a support stand (Magstim AFC Support Stand, Magstim Company, Whitland, Dyfed, UK). The coil was oriented at ∼45°, inducing a posterior-to-anterior current flow across the motor cortex, and moved across the left motor cortex while delivering stimulation in order to locate the optimal coil position to stimulate FCR (Rossini et al. 2015 (link)). The position was marked with a non-permanent marker to ensure consistency of recordings over the session. The positions and orientations of the coil was monitored continuously, and if necessary, adjusted to align with the scalp markings. During all the interventions, the stimulation was controlled through Spike2 (Cambridge Electronic Design, Cambridge, UK) software. We estimated for each subject an individual resting MT, the smallest intensity of stimulation necessary to elicit peak-to-peak MEP amplitudes of at least 50 μV in at least 5 out of 10 trials with 5 s IPIs, following the relative frequency method (Rossini et al. 1994 (link)). MT values were used to calculate the intensities to be set during the recording phase.
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5

Plasticity-inducing Continuous Theta-Burst Stimulation

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A Magstim Rapid stimulator connected to an air-cooled figure-of-eight
coil (Magstim Company, Dyfed, UK) applied cTBS with a biphasic pulse waveform to
the optimal scalp position for evoking responses in the FDI. The cTBS protocol
consisted of 600 pulses delivered in triplets at 50Hz, repeated at 5Hz for a
total of 40 s.34 (link) In healthy
adults, there is evidence of good between-session reliability of cTBS.35 (link),36 (link) A paired cTBS paradigm with a 10 min interval between
cTBS trains was applied as it has been reported to induce a greater magnitude
and more consistent plasticity response.37 (link),38 (link) Between cTBS
trains, participants were asked to relax and refrain from muscle contraction of
the upper limb. The intensity of stimulation was set to 70% RMT, with RMT
assessed prior to cTBS application using the rTMS coil.
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6

Repetitive TMS on Directed Forgetting

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The data of experiment 2 was part of a larger study that focussed on replicating the effect of rTMS on directed forgetting and is reported elsewhere (see [60] ).
(which was not certified by peer review) is the author/funder. All rights reserved. No reuse allowed without permission. The stimulation was delivered using a Magstim Rapid stimulator with a figure-of-eight coil (magstim; www.magstim.com). Prior to the main experiment, individual T1-weighted MRI scans were acquired using a 3T Philips Achieva MRI scanner. In order to assure precise stimulation, individual MRI scans were co-registered with the position of the rTMS coil and the stimulation was guided by a neuronavigation system (Brainsight; Rogue Resolutions; https://www.rogue-resolutions.com). The coil was held in place manually and the precision of the stimulation was monitored throughout the experiment. The same MNI coordinates as in experiment 1 were used.
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7

Neuronavigated rTMS of DLPFC and Vertex

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The same stimulation parameters were used as in experiment 1. However, in this experiment, participants received both DLPFC and vertex stimulation in a blocked manner. The stimulation was delivered using a Magstim Rapid stimulator with a figure-of-eight coil (magstim; www.magstim.com). Prior to the main experiment, individual T1-weighted MRI scans were acquired using a 3T Philips Achieva MRI scanner. In order to assure precise stimulation, individual MRI scans were coregistered with the position of the rTMS coil, and the stimulation was guided by a neuronavigation system (Brainsight; Rogue Resolutions; https://www.rogue-resolutions.com). The coil was held in place manually, and the precision of the stimulation was monitored throughout the experiment. The same MNI coordinates as in experiment 1 were used.
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8

Repetitive rTMS for Left DLPFC Stimulation

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Repetitive Transcranial Magnetic Stimulation was administered with the Magstim Rapid Stimulator (Magstim Company Ltd., Whitland, UK) using a 70-mm, 8-shaped coil. Stimulation parameters were 15 Hz, 2,400 pulses/day at 100% of resting motor threshold (MT), once a day, 6 days/week for 4 weeks (24 sessions total). Stimulation was applied on the left DLPFC, identified for each subject through neuronavigation. Resting MT was defined as the minimum magnetic flux needed to elicit a response in a resting target muscle (abductor pollicis brevis) in 5/10 trials using single-pulse TMS administered to the contralateral primary motor cortex.
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9

Bilateral PFC and Insula Stimulation

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Magstim Rapid stimulator (Magstim Company, Whitland, Wales, UK) was used along with H4-Coil (Brainsway Ltd., Jerusalem, Israel) specifically designed to stimulate bilateral PFC and insula symmetrically (34 (link), 35 (link)). Subjects received 20 stimulations over 4 weeks as previously described (23 (link)). ITBS protocol consisted of bursts containing 3 pulses at 50 Hz repeated at 200-ms intervals for 2 s (i.e., at 5 Hz). A 2-s train of iTBS was repeated every 10 s for 190 s and 600 pulses (26 (link)). The intensity was set at 100% of the visual resting motor threshold (RMT). For maintenance treatment 1 weekly session of iTBS was administered for 2 months.
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10

Therapeutic Effects of rTMS in Stroke Rehabilitation

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rTMS was delivered with a Magstim Rapid stimulator (The Magstim Company, Ltd., Carmarthenshire, UK). The figure-8-shaped stimulating coil had a coil diameter of 70 mm. The site of stimulation, parameters, and motor threshold for the rTMS were set according to a previous study (Rossi et al., 2009). Stimulation frequency was 1 Hz and the intensity was 90% of motor threshold. The stimulation site was the contralateral primary motor cortex (M1) contralateral to the infarction. Continuous stimulation was delivered daily in one 30-minute session for 14 days. A total of 1,800 pulses were administered each day. In the control group, patients were given 30 minutes of sham stimulation once per day. Patients were able to hear magnetic stimulator, but did not receive any real magnetic stimulation. Rehabilitation training (exercise) was conducted twice a day for each group, with each session lasting 40 minutes. Therapeutic responses and adverse reactions were observed during all treatments.
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