Computed tomography examination was performed with a multislice spiral CT scanner (GE Optima 64, USA). Following the injection of 300 mg/mL of nonionic contrast medium (Omnipaque, Bayer Schering Pharma, leverkusen, Germany) at a rate of 2.5 to 3.00 mL/s, the image data for the arterial, portal venous, and delayed phases were obtained between 15-30 seconds, 50-60 seconds, and 2-3 minutes, respectively.37 (link) The CT scanning parameters were 120 kV, 270-300 mA, 5 mm layer thickness, and 5 mm outline space. The detector array was 128 × 0.625 mm. Moreover, the acquisition matrix size was 512 × 512 (time interval: 5 seconds) at a speed and dose of 3 mL/s and 1.2 to 1.5 mL/kg, respectively. Computed tomography scans were obtained through the picture archiving and communication system. Computed tomography values during the 4 phases were measured using Rad Works, version 5.1. Hepatocellular carcinoma was classified according to patterns of contrast enhancement and attenuation during different phases of the CT scan.
Optima 64
Manufactured by GE Healthcare
Sourced in United States
The Optima 64 is a computed tomography (CT) imaging system manufactured by GE Healthcare. It is designed to provide high-quality, multi-slice CT imaging for a variety of diagnostic applications.
Automatically generated - may contain errors
5 protocols using optima 64
1
Multiphase CT for Hepatocellular Carcinoma
2
Chest CT for COVID-19 Diagnosis
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The computed tomography was performed using GE Optima 64 slices made in the USA. Patients were examined in the supine position and the scanning range included the whole chest from the thoracic inlet down to the diaphragm. MSCT of the chest was observed for signs of recent COVID-19 infection and diagnosis and severity were assessed using 5 grades CO-RADS system.
3
Multimodal Imaging Protocol for Evaluation
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The ultrasonographic examination was performed with Voluson E8 and Logiq E9 color ultrasound instruments (GE Healthcare, Chicago, IL, USA) using a convex array probe with a frequency of 2.5 to 5.0 MHz and a linear array probe with a frequency of 6 to 15 MHz. Contrast-enhanced ultrasonography was performed with intravenous injection of SonoVue (Bracco, Milan, Italy) at 0.03 mL/kg, computed tomography (CT) was performed with Optima 64 and Revolution 256-slice spiral CT scanners (GE Healthcare), and magnetic resonance imaging (MRI) was performed with a MAGNETOM Skyra 3.0T magnetic resonance scanner (Siemens Healthineers, Erlangen, Germany).
4
CT-guided Biopsy Protocol with Dual Scanners
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CT-guided biopsies were performed on two different scanners (Lightspeed16 and Optima64, GE Healthcare) using the following parameters of acquisition: Helical acquisition mode, 120 kVp with automatic tube current modulation, slice thickness of 2.5 or 5 mm and soft tissue reconstruction kernel. Biopsies were performed with patients in prone or supine decubitus depending on the location of the lesion. During the procedure, subsequent scans were taken to monitor the needle's path toward the lesion (Fig. 2). All the biopsies were performed using a 17-gauge coaxial outer needle and an 18-gauge inner automated full-core cutting needle (Biopince, Argon Medical).
5
Prospective Imaging Study on RECIST 1.1
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We prospectively studied imaging data of 40 patients included in a RECIST 1.1 [13] (link) clinical trial (Apr-Dec, 2017) at Centre Antoine Lacassagne, Nice, France. Follow-up was possible for 23 patients; 17 patients underwent baseline evaluation only. Median patient age was 63y, Max = 83y, Min = 37y; 26/40 were male, 14/40 female. Distribution of the diseases in the cohort is presented in Table 1.
Imaging data represented 96 time-points acquired on a CT scanner (GE Optima 64, Japan).
Reviews were performed by 7 senior radiologists with varying levels of expertise (6-10 years' experience) and one technologist (7 years' experience). The technologist underwent specific trainings that included: 1) sessions for advanced use of software dedicated to the monitoring of oncologic patients. Emphasis was placed on the eCRF production; 2) medical sessions; 3) a certification of Good Clinical Practice (GCP) designed for research staff conducting clinical trials with human participants (https://gcp.nidatraining.org/resources). 4) a specific radiologic training on RECIST criteria and their application.
Imaging data represented 96 time-points acquired on a CT scanner (GE Optima 64, Japan).
Reviews were performed by 7 senior radiologists with varying levels of expertise (6-10 years' experience) and one technologist (7 years' experience). The technologist underwent specific trainings that included: 1) sessions for advanced use of software dedicated to the monitoring of oncologic patients. Emphasis was placed on the eCRF production; 2) medical sessions; 3) a certification of Good Clinical Practice (GCP) designed for research staff conducting clinical trials with human participants (https://gcp.nidatraining.org/resources). 4) a specific radiologic training on RECIST criteria and their application.
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