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Pioglitazone

Manufactured by R&D Systems
Sourced in United States

Pioglitazone is a laboratory reagent used for research purposes. It is a thiazolidinedione compound that acts as a peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonist. This product is intended for use in in vitro research applications.

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2 protocols using pioglitazone

1

PPARα and PPARγ Modulation in Osteogenesis

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Periosteal cells that had been cultured in osteogenic induction medium were treated with 0.1 to 25 µM PPARα agonist WY14643, 0.1 to 10 µM PPARγ agonist pioglitazone, 0.1 to 10 µM PPARα antagonist GW6471, or 0.1 to 10 µM PPARγ antagonist T0070907 (all from R&D Systems, Minneapolis, USA). Media were changed every 3 days and the ligands were also added at each change of the medium.
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2

Osteogenic Differentiation with PPARγ Modulators

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Periosteal cells that had been cultured in osteogenic induction medium were treated with 5 and 10 µM concentrations of either PPARγ agonist pioglitazone or PPARγ antagonist T0070907 (all from R&D Systems, Minneapolis, MN, USA). Media were changed every 3 days, and the PPARγ agonist or antagonist was also added at each change of the medium.
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