Tgf β neutralizing antibody

Manufactured by BioXCell

The TGF-β neutralizing antibody is a laboratory reagent used for research purposes. It is designed to bind and neutralize transforming growth factor-beta (TGF-β), a multifunctional cytokine involved in various cellular processes. The core function of this antibody is to inhibit the biological activities of TGF-β in in vitro experimental settings.

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Lab products found in correlation

Salmonella typhimurium flagellin, by InvivoGen (1 mentions) Sphingosine 1 phosphate (s1p), by Cayman Chemical (1 mentions) Galunisertib, by Selleck Chemicals (1 mentions) Trametinib, by Selleck Chemicals (1 mentions) Rmil 6, by Thermo Fisher Scientific (1 mentions) Pgf2α, by Cayman Chemical (1 mentions) Alpelisib, by Selleck Chemicals (1 mentions) Ars 1620, by MedChemExpress (1 mentions) Lmk 235, by MedChemExpress (1 mentions) Rs 504393, by Cayman Chemical (1 mentions) Ccr2 inhibitor, by Santa Cruz Biotechnology (1 mentions) Rmtgf β1, by R&D Systems (1 mentions)

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TGF-β (2 citations)

2 protocols using tgf β neutralizing antibody

Intestinal Immune Regulation Mechanism

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Unless otherwise specified, all reagents were from Sigma-Aldrich. The following antibodies were used: Munc18b (Proteintech); SNAP23, STX3, VAMP2 (SYSY); VAMP8 (R&D); MUC2 (Santa Cruz); Th17/Treg staining kit, CD45, CD11B, CD11C, F4/80, CD103, IA-IE (BD); CD326, LAP, Il-10, IL-6, P-STAT3 (eBioscience); Citrobacter (Statens Serum Institute). EUB338 was from Eqixon. Salmonella Typhimurium flagellin was from Invivogen. Tgf-β neutralizing antibody was from BioXcell (Clone: 1D11).

Cornick S., Kumar M., Moreau F., Gaisano H, & Chadee K. (2019). VAMP8-mediated MUC2 mucin exocytosis from colonic goblet cells maintains innate intestinal homeostasis. Nature Communications, 10, 4306.

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Pharmacological Modulation of Signaling Pathways

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For in vitro studies: PGF2α (Cayman), rmFGF1 (Peprotech), rmPDGFBB (Peprotech), rmPDGFAA (Peprotech), rh/mWnt-5a (R&D), LPA (Santa Cruz biotech), rmIL6 (Peprotech), S1P (Cayman), Adapalene (Selleckchem), SAG (Tocris), rmTGFβ1(R&D), rmTGFβ2(R&D), rmTGFβ3 (R&D), CCL2 (BioLegend), CCR2 inhibitor (Santa Cruz Biotechnology), MEKi (PD0324901, 2 μM, Selleckchem), PI3Ki (LY294002, 2 μM, Selleckchem) , mTORi (Rapamycin, 100 nM, Selleckchem), Trametinib (Selleckchem, 50 nM), Alpelisib (Selleckchem, 5 μM) and ARS-1620 (MedChemExpress).
For in vivo studies: TGFβ neutralizing antibody (BioXCell, Clone 1D11, 200 μg, every other day, i.p), Clodronate liposome (Liposoma, 0.1 ml per 10 mg weight, every 5 days, i.p), Trametinib (Selleckchem, 0.3 or 1 or 3 mg/kg as indicated, q.d., oral), Alpelisib (Selleckchem, 50 mg/kg, once per day, oral), ARS-1620 (MedChemExpress, 200 mg/kg, q.d., oral), LMK-235 (MedChemExpress, 5 mg/kg, q.d., i.p.), Galunisertib (Selleckchem, 50 mg/kg, b.i.d., oral), mouse CCL2 neutralizing antibody (BioXCell, 5 mg/kg, every 2 days, i.p.), and RS 504393 (Cayman, 2 mg/kg, q.d., i.p.).

Hou P., Kapoor A., Zhang Q., Li J., Wu C.J., Li J., Lan Z., Tang M., Ma X., Ackroyd J.J., Kalluri R., Zhang J., Jiang S., Spring D.J., Wang Y.A, & DePinho R.A. (2020). Tumor microenvironment remodeling enables bypass of oncogenic KRAS dependency in pancreatic cancer. Cancer discovery, 10(7), 1058-1077.

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