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H c p f qnp gradient probe

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The H/C/P/F QNP gradient probe is a laboratory instrument designed for Nuclear Magnetic Resonance (NMR) spectroscopy. It is capable of detecting and analyzing hydrogen (H), carbon (C), phosphorus (P), and fluorine (F) nuclei within a sample. The probe utilizes gradient coils to provide spatial encoding of the sample, enabling more advanced NMR experiments and analysis.

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Lab products found in correlation

Drx 400, by Bruker (7 mentions) Drx 500, by Bruker (7 mentions) Lct premier, by Waters Corporation (4 mentions)

Spelling variants of this product

QNP probe (6 citations)

7 protocols using h c p f qnp gradient probe

1

NMR Spectroscopy Protocol for Organic Compounds

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Example 3

1H NMR were recorded at 400 or 500 MHz (Bruker DRX-400 Bruker with a H/C/P/F QNP gradient probe) spectrometer and 13C NMR spectra were recorded at 125 MHz (Bruker DRX 500 with broadband, inverse triple resonance, and high resolution magic angle spinning HR-MA probe spectrometer); chemical shifts are reported in δ (ppm) relative to the internal reference chloroform-d (CDCl3, 7.27 ppm).

US11390640B2. C-terminal Hsp90 inhibitors (2022-07-19). UNIVERSITY OF KANSAS [US]. Inventors: Brian S. J. Blagg [US], Bhaskar Reddy Kusuma [US], Teather Sundstrom [US].
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2

Characterization of Chemical Compounds

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1H NMR were recorded at 400 or 500 MHz (Bruker DRX-400 Bruker with a H/C/P/F QNP gradient probe) spectrometer and 13C NMR spectra were recorded at 125 MHz (Bruker DRX 500 with broadband, inverse triple resonance, and high resolution magic angle spinning, HR-MA probe spectrometer); chemical shifts are reported in δ (ppm) relative to the internal chloroform-d (CDCl3, 7.27 ppm). FAB (HRMS) spectra were recorded with a LCT Premier (Waters Corp., Milford, MA). The purity of all compounds was determined to be >95% purity as determined by 1H NMR and 13C NMR spectra, unless otherwise noted. The most active five compounds were verified for >95% purity by HPLC analyses. TLC was performed on glass backed silica gel plates (Uniplate) with spots visualized by UV light. All solvents were reagent grade and, when necessary, were purified and dried by standard methods. Concentration of solutions after reactions and extractions involved the use of a rotary evaporator operating at reduced pressure.
Muth A., Crowley V., Khandelwal A., Mishra S., Zhao J., Hall J, & Blagg B.S. (2014). Development of Radamide Analogs as Grp94 Inhibitors. Bioorganic & medicinal chemistry, 22(15), 4083-4098.
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3

Characterization of Organic Compounds by NMR and Mass Spectrometry

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1H NMR were recorded at 400 or 500 MHz (Bruker DRX- 400 Bruker with a H/C/P/F QNP gradient probe) spectrometer and 13C NMR spectra were recorded at 125 MHz (Bruker DRX 500 with broadband, inverse triple resonance, and high resolution magic angle spinning HR-MA probe spectrometer); chemical shifts are reported in δ (ppm) relative to the internal reference CDCl3-d (CDCl3, 7.27 ppm). FAB (HRMS) spectra were recorded with a LCT Premier (Waters Corp., Milford, MA) spectrometer. The purity of all compounds was determined to be >95% as determined by 1H NMR and 13C NMR spectra, unless otherwise noted. TLC was performed on glass- backed silica gel plates (Uniplate) with spots visualized by UV light. All solvents were reagent grade and, when necessary, were purified and dried by standard methods. Concentration of solutions after reactions and extractions involved the use of a rotary evaporator operating at reduced pressure.
Byrd K.M., Subramanian C., Sanchez J., Motiwala H.F., Liu W., Cohen M.S., Holzbeierlein J, & Blagg B.S. (2016). Synthesis and biological evaluation of novobiocin core analogs as Hsp90 inhibitors. Chemistry (Weinheim an der Bergstrasse, Germany), 22(20), 6921-6931.
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4

NMR Spectroscopic Analysis Protocol

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Example 3

1H NMR were recorded at 400 or 500 MHz (Bruker DRX-400 Bruker with a H/C/P/F QNP gradient probe) spectrometer and 13C NMR spectra were recorded at 125 MHz (Bruker DRX 500 with broadband, inverse triple resonance, and high resolution magic angle spinning HR-MA probe spectrometer); chemical shifts are reported in δ (ppm) relative to the internal reference chloroform-d (CDCl3, 7.27 ppm).

US10882881B2. C-terminal Hsp90 inhibitors (2021-01-05). UNIVERSITY OF KANSAS [US]. Inventors: Brian S. J. Blagg [US], Bhaskar Reddy Kusuma [US], Teather Sundstrom [US].
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5

NMR Spectroscopic Analysis Procedure

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Example 3

1H NMR were recorded at 400 or 500 MHz (Bruker DRX-400 Bruker with a H/C/P/F QNP gradient probe) spectrometer and 13C NMR spectra were recorded at 125 MHz (Bruker DRX 500 with broadband, inverse triple resonance, and high resolution magic angle spinning HR-MA probe spectrometer); chemical shifts are reported in δ (ppm) relative to the internal reference chloroform-d (CDCl3, 7.27 ppm).

US10030041B2. C-terminal Hsp90 inhibitors (2018-07-24). UNIVERSITY OF KANSAS [US]. Inventors: Brian S. J. Blagg [US], Bhaskar Reddy Kusuma [US], Teather Sundstrom [US].
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6

Detailed Characterization of Organic Compounds

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1H NMR were recorded at 400 or 500 MHz (Bruker DRX- 400 Bruker with a H/C/P/F QNP gradient probe) spectrometer and 13C NMR spectra were recorded at 125 MHz (Bruker DRX 500 with broadband, inverse triple resonance, and high resolution magic angle spinning HR-MA probe spectrometer); chemical shifts are reported in δ (ppm) relative to the internal reference CDCl3 (CDCl3, 7.26 ppm). FAB (HRMS) spectra were recorded with a LCT Premier (Waters Corp., Milford, MA) spectrometer and IR spectra were recorded on a Magna FT-IR spectrometer (Nicolet Instrument Corporation, Madison, WI). The purity of all compounds was determined to be >95% as determined by 1H NMR and 13C NMR spectra, unless otherwise noted. TLC was performed on glass- backed silica gel plates (Uniplate) with spots visualized by UV light. All solvents were reagent grade and, when necessary, were purified and dried by standard methods. Concentration of solutions after reactions and extractions involved the use of a rotary evaporator operating at reduced pressure. Detailed experimental procedures can be found in the supporting information.
Byrd K.M., Kent C.N, & Blagg B.S. (2017). Synthesis and biological evaluation of stilbene analogs as Hsp90 C-terminal inhibitors. ChemMedChem, 12(24), 2022-2029.
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7

NMR Characterization of Organic Compounds

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1HNMR were recorded at 400 or 500 MHz (Bruker DRX-400 Bruker with a H/C/P/F QNP gradient probe) spectrometer and 13C NMR spectra were recorded at 100 or 125 MHz (Bruker DRX 500 with broadband, inverse triple resonance, and high resolution magic angle spinning HR-MA probe spectrometer); chemical shifts are reported in δ (ppm) relative to the internal reference chloroform-d (CDQ3, 7.27 ppm) or dimethyl sulfoxide-d6 (DMSO-d6, 2.50 ppm). High resolution mass spectra (FAB) were recorded with a LCT Premier (Waters Corp., Milford, MA) spectrometer. The purity of all compounds was determined to be >95% as determined by HPLC analysis. TLC was performed on glassbacked silica gel plates (Uniplate) with spots visualized by UV light. All solvents were reagent grade and when necessary, were purified and dried by standard methods. Concentration of solvents occurred via the use of a rotary evaporator operating at reduced pressure.
Hall J.A., Seedarala S., Zhao H., Garg G., Ghosh S, & Blagg B.S. (2016). Novobiocin Analogs That Inhibit the MAPK Pathway. Journal of medicinal chemistry, 59(3), 925-933.
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