Humanexon510s duo bead chips

Manufactured by Illumina

The HumanExon510S-Duo Bead Chips is a laboratory equipment designed for high-throughput gene expression analysis. The product provides a platform for interrogating the human exome, enabling comprehensive coverage of protein-coding regions. The Bead Chips utilize a proprietary bead-based array technology to facilitate simultaneous detection and quantification of thousands of human transcripts.

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Lab products found in correlation

Humanhap 550k, by Illumina (2 mentions) Genome wide human snp array 6, by Thermo Fisher Scientific (1 mentions) Hl 60, by American Type Culture Collection (1 mentions) Jurkat cell, by American Type Culture Collection (1 mentions)

2 protocols using humanexon510s duo bead chips

Genotyping of Lymphoblastoid Cell Lines

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287 lymphoblastoid cell lines (LCLs) were obtained from the Coriell Institute. DNA from these 287 LCLs was genotyped with the Affymetrix Human SNP Array 6.0 at the Coriell Institute, and with the Illumina HumanHap550K and HumanExon510S-Duo Bead Chips in our laboratory. The genotype data were deposited in the National Center for Biotechnology Information Gene Expression Omnibus (GEO accession: GSE23120) (20 (link)).

Nguyen T.T., Gao H., Liu D., Philips T.J., Ye Z., Lee J.H., Shi G.X., Copenhaver K., Zhang L., Wei L., Yu J., Zhang H., Barath A., Luong M., Zhang C., Gaspar-Maia A., Li H., Wang L., Ordog T, & Weinshilboum R.M. (2022). Glucocorticoids unmask silent non-coding genetic risk variants for common diseases. Nucleic Acids Research, 50(20), 11635-11653.

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Genetic and Expression Profiling of Human Cell Lines

Cited 1 time

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The HL-60 and Jurkat cell lines were obtained from the American Type Culture Collection (ATCC, Manassas, VA, USA). The “Human Variation Panel” of lymphoblastoid cell lines (LCLs) was obtained from the Coriell Institute (Camden, NJ). DNA from these 287 LCLs had been genotyped in the Coriell Institute using the Affymetrix Genome-Wide Human SNP Array 6.0 (Affymetrix, Santa Clara, CA), and in our laboratory using Illumina HumanHap 550K and HumanExon 510S-Duo BeadChips (Illumina, San Diego, CA). Imputation was then performed using 1000 Genomes data (http://www.1000genomes.org/data). We also generated gene expression data for these LCLs with Affymetrix U133/2.0/Plus GeneChip expression arrays, as described previously (16 (link)). Jurkat cells were cultured in Roswell Park Memorial Institute (RPMI) media with 10% fetal bovine serum (FBS), and the HL-60 and LCL cells were cultured in the same media with 15% FBS.

Fasching P.A., Liu D., Scully S., Ingle J.N., Lyra PC J.r., Rack B., Hein A., Ekici A.B., Reis A., Schneeweiss A., Tesch H., Fehm T.N., Heinrich G., Beckmann M.W., Ruebner M., Huebner H., Lambrechts D., Madden E., Shen J., Romm J., Doheny K., Jenkins G.D., Carlson E.E., Li L., Fridley B.L., Cunningham J.M., Janni W., Monteiro A.N., Schaid D.J., Häberle L., Weinshilboum R.M, & Wang L. (2022). Identification of Two Genetic Loci Associated with Leukopenia after Chemotherapy in Breast Cancer Patients. Clinical cancer research : an official journal of the American Association for Cancer Research, 28(15), 3342-3355.

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