At turbo and cs brightfield slide scanning systems

Manufactured by Leica

The AT Turbo and CS brightfield slide scanning systems are high-performance laboratory equipment designed for digitizing microscope slides. These systems capture high-resolution images of specimens on slides, enabling efficient digital archiving and analysis. The core function of these scanners is to convert physical microscope slides into digital image files.

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Lab products found in correlation

Bond rx autostainer, by Leica (2 mentions) Pd l1, by Cell Signaling Technology (2 mentions)

Spelling variants of this product

Leica AT Turbo (3 citations) CS slide scanning system (2 citations) Slide scanning system (2 citations)

2 protocols using at turbo and cs brightfield slide scanning systems

Quantitative Immunohistochemistry for Tumor Biomarkers

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Four-micron-thick serial sections of formalin-fixed paraffin-embedded (FFPE) tumor biopsy tissue were immunostained for CD8 (Dako Agilent, catalog no. M7103) and PD-L1 (Cell Signaling Technology, catalog no. 13684). Slides were stained in a Leica Bond RX Autostainer and scanned on Aperio's AT Turbo and CS brightfield slide scanning systems (Leica Biosystems Inc.). Staining and analysis were performed by Flagship Biosciences.
Full-scan analysis was performed using Flagship Bioscience's proprietary computational tissue analysis (cTA) imaging software system. Digital H-scores ranging from 0 to 300 were calculated using the following standard formula: [3 × % cells +3 intensity] + [2 × % cells +2 intensity] + [1 × % cells +1 intensity].

Ribas A., Medina T., Kirkwood J.M., Zakharia Y., Gonzalez R., Davar D., Chmielowski B., Campbell K.M., Bao R., Kelley H., Morris A., Mauro D., Wooldridge J.E., Luke J.J., Weiner G.J., Krieg A.M, & Milhem M.M. (2021). Overcoming PD-1 Blockade Resistance with CpG-A Toll-Like Receptor 9 Agonist Vidutolimod in Patients with Metastatic Melanoma. Cancer Discovery, 11(12), 2998-3007.

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CD8 and PD-L1 Immunostaining in FFPE Tumor Biopsies

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Four-micrometer-thick serial sections of formalin-fixed paraffin-embedded (FFPE) tumor biopsy tissue were immunostained for CD8 (Dako Agilent, catalog #M7103) and PD-L1 (Cell Signaling Technology, catalog #13684). Slides were stained in a Leica Bond RX Autostainer and scanned on Aperio’s AT Turbo and CS bright-field slide scanning systems (Leica Biosystems Inc., Buffalo Grove, IL). Staining and analysis were performed by Flagship Biosciences (Westminster, CO).
Full-scan analysis was performed using Flagship Bioscience’s proprietary computational tissue analysis (cTA) imaging software system. Digital H-scores ranging from 0 to 300 were calculated using the following standard formula: [3 × % cells +3 intensity] + [2 × % cells +2 intensity] + [1 × % cells +1 intensity].

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