Hydrochlorothiazide (HCT) was a generous gift of Menarini (Italy). Precirol®ATO5 (Glyceryl distearate/palmitostearate), Transcutol®HP (highly purified diethylene glycol monoethyl ether), Labrafac™ PG (propylene glycol dicaprylocaprate), Capryol™ 90 (propylene glycol monocaprylate, type II), LabrafilTM Lipophile WL1349 (medium-chain triglycerides) and Labrasol® (PEG-8 caprylic/capric glycerides) were kindly provided by Gattefossé (Saint-Priest, France). Oleic acid, 1-butanol, Tween®20 (polyoxyethylene sorbitan monolaurate) and Tween®80 (polyoxyethylene sorbitan monoleate) were from Merck (Darmstadt, Germany), castor and peanut oils from Galeno (Prato, Italy), sesame oil from Farvima (Firenze, Italy), sodium taurocholate from Prodotti Chimici e Alimentari S.p.A. (Basaluzzo (AL), Italy), lecithin from Carlo Erba Reagents (Milan, Italy), glycofurol (tetrahydrofurfurylether polyetylenglycol) and phosphatidylcholine from Sigma-Aldrich (St. Louis, USA). Solutol®HS15 (2-hydroxyethyl 12-hydroxyoctadecanoate) and Pluronic®F68 (Poloxamer 188) were from BASF (Ludwigshafen, Germany). Purified water was obtained by reverse osmosis (Elix® Millipore, MD, USA). All other chemicals were of analytical grade.
Poloxamer 188 pluronic f68
Manufactured by BASF
Sourced in Germany
Poloxamer 188 (Pluronic F68) is a non-ionic, water-soluble surfactant. It is a block copolymer composed of polyethylene oxide and polypropylene oxide segments. Poloxamer 188 is commonly used as an emulsifier, wetting agent, and stabilizer in pharmaceutical and cosmetic formulations.
Automatically generated - may contain errors
Lab products found in correlation
Tween 80, by Merck Group (2 mentions)
Glycofurol, by Merck Group (1 mentions)
Phosphatidylcholine, by Merck Group (1 mentions)
Oleic acid, by Merck Group (1 mentions)
Tween 20, by Merck Group (1 mentions)
Solutol hs 15, by BASF (1 mentions)
1 butanol, by Merck Group (1 mentions)
Astaxanthin, by Biosynth (1 mentions)
Hplc grade methanol, by Merck Group (1 mentions)
Acetonitrile, by Merck Group (1 mentions)
Precirol ato 5, by Gattefosse (1 mentions)
Dab 3 3 diaminobenzidine, by Merck Group (1 mentions)
Ethanol, by Merck Group (1 mentions)
Lutrol f68, by BASF (1 mentions)
Dichloromethane, by Thermo Fisher Scientific (1 mentions)
Sodium trifluoroacetate, by Merck Group (1 mentions)
N n dimethylformamide (dmf), by Thermo Fisher Scientific (1 mentions)
Triphenylphosphine, by Merck Group (1 mentions)
Triethylamine, by Thermo Fisher Scientific (1 mentions)
Pd 10 desalting column, by GE Healthcare (1 mentions)
9 protocols using poloxamer 188 pluronic f68
1
Formulation and Characterization of Lipid-Based Drug Delivery Systems
2
Donepezil-Astaxanthin Nanoformulation Development
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Donepezil was a gift from Ranbaxy Research Laboratory (Gurgaon, India). Astaxanthin was purchased from Carbosynth Limited (Berkshire, UK). Precirol® ATO 5 (glyceryl palmitostearate) was a gift from Gattefossé (Saint-Priest, Cedex, France). Oleic acid and Tween® 80 (polysorbate 80) were purchased from Loba Chemie Laboratory Reagents and Fine Chemicals (Mumbai, India). Pluronic® F68 (poloxamer 188) was purchased from BASF SE (Ludwigshafen, Germany). HPLC-grade methanol and acetonitrile were purchased from Sigma-Aldrich (St. Louis, MO, USA). Sodium dihydrogen phosphate and phosphoric acid were purchased from El-Nasr Pharmaceutical Chemicals Co. (Cairo, Egypt).
3
Synthesis and Characterization of Lipid-based Nanoparticles
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3,3′-Diaminobenzidine (DAB), mannitol, glucose, and ethanol were purchased from Merck (ST. Louis, MO, USA). Pluronic F68 (poloxamer 188) was purchased from BASF (Florham Park, NJ, USA), and Compritol 888 ATO, a mixture of mono-, di-, and triglycerides of behenic acid, was obtained from Gattefossè (Milan, Italy). Lutrol F68 was provided by BASF ChemTrade GmbH (Burgbernheim, Germany).
4
Poloxamer 188 Synthesis and Characterization
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All animal experiments were conducted in accordance with humane practices as directed by the Federal Animal Welfare Act, National Institutes of Health (NIH) guidelines, standards of the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC International), and at the university level under the regulation of the University Committee on the Use and Care of Animals. The protocols were approved by the University of Minnesota Institutional Animal Care and Use Committee.
Poloxamer 188 (Pluronic F68) was generously provided by BASF (Wyandotte, MI). p-Toluenesulfonyl chloride (>99%) was purchased from Acros Organics (Fair Lawn, NJ). Triethylamine (99%), tetrahydrofuran (HPLC grade), N,N-dimethylformamide (DMF) (certified ACS), and dichloromethane (certified ACS) were purchased from Fisher Scientific (Hampton, NH). Sodium azide (>99.5%), triphenylphosphine (99%), α-cyano-4-hydroxycinnamic acid (>98%), sodium trifluoroacetate (98%), and anhydrous N,N-dimethylformamide (99.8%) were purchased from Sigma-Aldrich (St. Louis, MO). Alx647 NHS Ester (N-hydroxysuccinimide ester) was purchased from Thermo Fisher Scientific (Waltham, MA). Molecular sieves (4 Å) were purchased from Mallinckrodt (Staines-upon-Thames, UK). PD-10 desalting columns were purchased from GE Healthcare (Chicago, IL).
Poloxamer 188 (Pluronic F68) was generously provided by BASF (Wyandotte, MI). p-Toluenesulfonyl chloride (>99%) was purchased from Acros Organics (Fair Lawn, NJ). Triethylamine (99%), tetrahydrofuran (HPLC grade), N,N-dimethylformamide (DMF) (certified ACS), and dichloromethane (certified ACS) were purchased from Fisher Scientific (Hampton, NH). Sodium azide (>99.5%), triphenylphosphine (99%), α-cyano-4-hydroxycinnamic acid (>98%), sodium trifluoroacetate (98%), and anhydrous N,N-dimethylformamide (99.8%) were purchased from Sigma-Aldrich (St. Louis, MO). Alx647 NHS Ester (N-hydroxysuccinimide ester) was purchased from Thermo Fisher Scientific (Waltham, MA). Molecular sieves (4 Å) were purchased from Mallinckrodt (Staines-upon-Thames, UK). PD-10 desalting columns were purchased from GE Healthcare (Chicago, IL).
5
Formulation of Meloxicam Powder
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Meloxicam was supplied by EGIS Ltd., (Budapest, Hungary), β-D-Mannitol (M) was obtained from Hungaropharma Plc. (Budapest, Hungary), and Poloxamer 188 (Pluronic F68) was purchased from BASF (Ludwigshafen, Germany). D-Mannitol was supplied from Molar Chemicals Ltd. (Budapest, Hungary). Trehalose dihydrate was purchased from Quadrant Holdings (Cambridge, UK). Distilled and ultrapurified water was used (Milli-Q, Millipore, Merck KGaA, Darmstadt, Germany).
6
Cardioprotective Lipid Nanoparticle Formulation
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The following materials were purchased or obtained from the sources in parentheses: Lq (Nanjing Shizhou Biotechnology Co., Ltd., Nanjing, China); egg lecithin (Lipoid E80) and medium-chain triglycerides (MCTs) (Lipoid KG, Ludwigshafen, Germany); soybean lecithin (EPIKURON 170, Degussa Food Ingredients, Germany); soybean oil (Zhejiang Tianyushan Medicinal Oil Co., Ltd., LongYou, China); poloxamer 188 (Pluronic F68®) (BASF AG, Ludwigshafen, Germany); glycerol (Shantou Jiahe Biotechnology Co., Ltd., Shantou, China); oleic acid (Xi’an Libang Pharmaceutical Co., Ltd., Xi’an, China); creatine kinase (CK), creatine kinase isoenzymes (CK-MB), brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP) and cardiac troponin-T (cTnT) kits (Nanjing Jiancheng Saihao Technology Co., Ltd.); interleukin-1β (IL-1β), interleukin 6 (IL-6), tumour necrosis factor-α (TNF-α), superoxide dismutase (SOD), and malondialdehyde (MDA) kits (Jiangsu Kaiji Biotechnology Co., Ltd., China); and ROS and glutathione (GSH) kits (Nanjing Jiancheng Bioengineering Institute). All chemicals and reagents used were of analytical or chromatographic grade. The animals used in this study were obtained from the Qinglong Mountain Animal Breeding Farm.
7
Formulation Development of Lipid Nanoparticles
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PPD with a purity of ≥98% was purchased from Jingke Chemistry Technology Co., Ltd., Shanghai, China. Phospholipid (PL-100M) with a phosphatidylcholine content of 80% (w/w) was purchased from Shanghai Advanced Vehicle Technology Corporation, Shanghai, China. Avicel CL-611 was purchased from FMC Corporation, Philadelphia, PA, USA. Poloxamer 188 (Pluronic F68) was purchased from BASF Corporation, Ludwigshafen, Germany. All other chemical reagents were of analytical grade or higher.
8
Preparation and Characterization of Novel Alkaloid Compounds
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CAT3 (purity > 99%), PF403 (purity > 99%), and (+)-Deoxytylophorinine (CAT) (purity > 99%) were prepared at our institute (Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China), and the structures were confirmed by infrared, two-dimensional nuclear magnetic resonance, and Fourier transform mass spectrometry. OA and Lipoid S75 (soy lecithin with 68% phosphatidylcholine) were both purchased from Lipoid KG (Ludwigshafen, Germany). Poloxamer188 (Pluronic F68) and Tween 80 were received as gifts from BASF (Ludwigshafen, Germany). Compritol 888 ATO was received as a gift from Gattefosse (Saint-Priest Cedex, France). The solvents for high-performance liquid chromatography (HPLC) were obtained from Thermo Fisher Scientific (Waltham, MA, USA). All other chemicals used were of analytical grade.
9
Cyclodextrin-Based Formulations for Hydrochlorothiazide
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Hydrochlorothiazide (HCT) was kindly supplied by Menarini (L’Aquila, Italy). Hydroxypropyl-β-cyclodextrin (Kleptose®HP, HPβCD average substitution degree DS = 0.85) and β-cyclodextrin were a gift from Roquette (Lestrem, France) and Sulfobutylether-β-cyclodextrin (Captisol®, SBEβCD) from Ligand Pharmaceuticals, Inc. (San Diego, CA, USA). Precirol®ATO5 (Glyceryldistearate NF/glycerylpalmitostearate), was kindly provided by Gattefossé (Milan, Italy); polyoxyethylene (Tween®80) was from Merck (Hohenbrunn, Germany), Poloxamer 188 (Pluronic®F68) from BASF (Ludwigshafen, Germany) and castor oil from Galeno (Prato, Italy). Purified water was obtained by reverse osmosis (Elix® Millipore, Baltimore, MD, USA). All other chemicals were of analytical grade.
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