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2 protocols using 4 nitroaniline

1

Synthesis and Characterization of Benzothiazole Derivatives

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All reagents, catalysts,
and chemicals utilized in the study were of analytical quality and
supplied by commercial providers. The chemicals used in this study
were sourced from various suppliers. 2-Aminobenzothiazole (Sigma-Aldrich,
99%), sulfapyridine (NENTECH, U.K., 99%), sulfaguanidine (Tokyo Chemical
Industry, Japan, 98%), piperazine (Central Dreug House, India, 99%),
benzylamine (Loba Chemi, India, 99%), cyclohexylamine (Sigma-Aldrich,
99%), 3,4 dimethylaniline (GCC, U.K., 98%), 4-chloroaniline (Sigma-Aldrich,
98%), 4-bromoaniline (Sigma-Aldrich, 90%), 4-fluoroaniline (Sigma-Aldrich,
99%), 4-nitroaniline (Janssen, Belgium, 98%), diethylamine (GCC, U.K.,
98%), m-toluidine (Sigma-Aldrich, 99%), morpholine
(Tokyo Chemical Industry, Japan, 99%), dimethylformamide (DMF) (Carlo
Erba, France, 99.9%), acetone (Carlo Erba, France, 99%), triethylamine
(TEA) (TEDIA, 99%), ethanol (Carlo Erba, France, 98%), n-hexane (Carlo Erba, France, 95%), sodium bicarbonate (NaHCO3) (GCC, U.K., 99.5%), sodium hydroxide (NaOH) (GCC, U.K.,
99.5%), chloroform (Carlo Erba, France, 99.9%), and dimethyl sulfoxide
(DMSO) (Carlo Erba, France, 99%) and monochloroacetyl chloride (α
Chemika, India) were used.
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2

Synthesis and Characterization of Sulfanilamide Derivatives

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All of the reagents and
chemicals were of analytical grade and purchased from commercial suppliers.
Sulfapyridine (NENTECH, U.K., 99%), sulfaguanidine (Tokyo Chemical
Industry, Japan, 98%), cyanuric chloride (Acros Organics, China, 99%),
aniline (GCC, U.K., 99.5%), benzylamine (LobaChemi, India, 99%), cyclopropylamine
(Sigma-Aldrich, 98%), cyclohexyl amine (Sigma-Aldrich, 99%), diethylamine
(GCC, U.K., 98%), m-toluidine (Sigma-Aldrich, 99%),
3,4-dimethylaniline (GCC, U.K., 98%), 4-chloroaniline (Sigma-Aldrich,
98%), 4-bromoaniline (Sigma-Aldrich, 90%), 4-fluoroaniline (Sigma-Aldrich,
99%), 4-nitroaniline (Janssen, Belgium, 98%), morpholine (Tokyo Chemical
Industry, Japan, 99%), acetone (Carlo Erba, France, 99%), ethanol
(Carlo Erba, France, 98%), dimethylformamide (DMF) (Carlo Erba, France,
99.9%), n-hexane (Carlo Erba, France, 95%), sodium
bicarbonate (NaHCO3) (GCC, U.K., 99.5%), sodium hydroxide
(NaOH) (GCC, U.K., 99.5%), triethylamine (TEA) (TEDIA, 99%), chloroform
(Carlo Erba, France, 99.9%) and dimethyl sulfoxide (DMSO) (Carlo Erba,
France, 99%).
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