Rabeprazole

Manufactured by Merck Group

Sourced in Italy, Germany

Rabeprazole is a proton pump inhibitor (PPI) that works by reducing the amount of acid produced in the stomach. It is commonly used in the treatment of conditions such as gastroesophageal reflux disease (GERD), peptic ulcers, and other acid-related disorders.

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Lab products found in correlation

Lansoprazole, by Merck Group (2 mentions) Pantoprazole, by Merck Group (2 mentions) Omeprazole, by Merck Group (1 mentions) Pluronic f 127, by Thermo Fisher Scientific (1 mentions) Adenosine triphosphate (atp), by Merck Group (1 mentions) Lipopolysaccharides (lps), by Merck Group (1 mentions) Hepes, by Merck Group (1 mentions) Pipes, by Merck Group (1 mentions) Zymosan, by Merck Group (1 mentions) Pbfi am, by Thermo Fisher Scientific (1 mentions) Flagellin, by Alexis Biochemicals (1 mentions) Pam3csk4, by InvivoGen (1 mentions) Esomeprazole, by Merck Group (1 mentions)

Spelling variants of this product

Rabeprazole sodium (2 citations)

3 protocols using rabeprazole

High-Purity Compound Characterization

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All compounds tested
were purchased
from reputable sources (Sigma-Aldrich, Toronto Research Chemicals,
Cayman Chemical), with purity of ≥95%, as determined by standard
analytical methods. The certificate of analysis for the final selected
compounds including pantoprazole (Toronto Research Chemicals), lansoprazole,
omeprazole, and rabeprazole (Sigma) as well as NMR and MS spectra
confirming their identity are shown in Supporting
Information purity file.

Fako V.E., Wu X., Pflug B., Liu J.Y, & Zhang J.T. (2014). Repositioning Proton Pump Inhibitors as Anticancer Drugs by Targeting the Thioesterase Domain of Human Fatty Acid Synthase. Journal of Medicinal Chemistry, 58(2), 778-784.

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Stimuli-induced Intracellular Ion Dynamics

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PIPES, MOPS, TES, HEPES, LPS (from Escherichia coli serotype 0111:B4), poly(I:C), ATP, zymosan, OME, ESO, lansoprazole, pantoprazole and rabeprazole were from Sigma-Aldrich (Milan, Italy); R848 and Pam(3)CSK(4) were from Invivogen (Milano, Italy); Flagellin was from Alexis Biochemicals (Enzo Life, Rome, Italy); nigericin was from Calbiochem (DBA, Milan, Italy); PBFI-aM (the cell-permeant acetoxymethyl ester of PBFI) and pluronic F-127 (a non-ionic detergent polyol used to facilitate cell loading of large dye molecules) were from Molecular Probes (Thermofisher, Monza, Italy).

Balza E., Piccioli P., Carta S., Lavieri R., Gattorno M., Semino C., Castellani P, & Rubartelli A. (2016). Proton pump inhibitors protect mice from acute systemic inflammation and induce long-term cross-tolerance. Cell Death & Disease, 7(7), e2304-.

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Purchasing and Dissolving Proton Pump Inhibitors

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Four PPIs (rabeprazole, dexlansoprazole, esomeprazole, and pantoprazole) were purchased from Sigma-Aldrich (Merck KGaA, Darmstadt, Germany) and dissolved in dimethyl sulfoxide, and a pcDNA3.1-Tmem192-3xHA plasmid was purchased from Addgene.

Lee W.P. (2022). Suppression of vacuolar-type ATPase and induction of endoplasmic reticulum stress by proton pump inhibitors. Journal of the Chinese Medical Association : JCMA, 85(9).

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