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BALB/c, C57BL/6J, CBA/CaHN-Btk^xid/J and CBA/CaJ mice were obtained from the Jackson Laboratory (Bar Harbor, ME USA). Breeding pairs of DO11.10 TCR Transgenic BALB/c mice were obtained from The Jackson Laboratory and housed in a specific pathogen free facility during the experiments at Rutgers NJMS research animal facility, Newark, NJ. Caspase-1 KO mice were obtained from Dr. Thirumala-Devi Kanneganti (St Jude Hospital, Memphis, TN, USA) and B cell deficient Jh^–/– mice on BALB/c background were obtained from TACONIC Laboratory (Hudson, NY, USA). All mice for our experiments at Rutgers NJMS research animal facility were housed in a specific pathogen free, barrier facility excluding common adventitious pathogens. The studies have been reviewed and approved by the Institutional Animal Care and Use Committee at Rutgers—the State University of New Jersey. Experiments with ST2^−/− mice were performed at the Children’s Hospital of Philadelphia, USA with the approval of The Children’s Hospital of Philadelphia Institutional Animal Care and Use Committee. The experiments herein were conducted according to the principles set forth in the Guide for the Care and Use of Laboratory Animals, Institute of Animal Resources, National Research Council, Department of Health, Education and Welfare (US National Institutes of Health).