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Cobas 311 analyzer

Manufactured by Roche
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Sourced in Germany

The Cobas 311 analyzer is a compact, automated clinical chemistry analyzer designed for routine laboratory testing. It performs a range of diagnostic tests on various sample types, including serum, plasma, and urine. The Cobas 311 provides reliable and efficient results to support clinical decision-making.

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Cobas c 311/501 analyzers Cobas 311 Cobas analyzer

4 protocols using cobas 311 analyzer

1

Capillary and Venous Blood Analysis

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Capillary blood glucose was measured using Glucometer (one touch ultra mini ACCU-CHEK®Aviva). [16] [17] [18] Venous blood specimens were obtained via venipuncture for blood urea nitrogen and creatinine in a sterile plain bottle at the hospital's central chemical pathology laboratory where the blood chemistry auto-analyzer model cobas 311 analyzer (F. Hoffman-La Roche Ltd) was used.
Abubakar I.G., Buba F., Oyati A.I., Talle M.A, & Anjorin C.O. (2023). Prevalence of Doppler-Derived Left Ventricular Diastolic Dysfunction Among Newly Diagnosed Hypertensive Patients. Nigerian journal of clinical practice, 26(11).
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2

Plasma Biomarkers of Oxidative Stress

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Plasma lactate was measured using a Cobas 311 analyzer (Roche, Mannheim, Germany). Plasma protein carbonyls were measured using a commercially available ELISA kit (BioCell Corporation, Auckland, New Zealand) according to the manufacturer's instructions. Reduced glutathione (GSH) was measured in blood samples using the Bioxytech GSH/GSSG-412 assay kit (OxisResearch, Portland, OR, USA) according to the manufacturer's instructions.
Broome S.C., Pham T., Braakhuis A.J., Narang R., Wang H.W., Hickey A.J., Mitchell C.J, & Merry T.L. (2022). MitoQ supplementation augments acute exercise-induced increases in muscle PGC1α mRNA and improves training-induced increases in peak power independent of mitochondrial content and function in untrained middle-aged men. Redox Biology, 53, 102341.
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3

Mouse Serum Biochemical Markers

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Serum was collected from mouse eyeballs after centrifugation. Biochemical indicators of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total protein (TP2), uric acid (UA), high-density lipoprotein 3 (HDCL3) and high-density lipoprotein 4 (HDCL4) were tested by a cobas 311 analyzer (Roche diagnostics) according to guidelines provided by the manufacturer.
Yu Y., Liu H., Yuan L., Pan M., Bei Z., Ye T, & Qian Z. (2024). Niclosamide - encapsulated lipid nanoparticles for the reversal of pulmonary fibrosis. Materials Today Bio, 25, 100980.
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4

Measuring Serum Urate in REGARDS Study

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Baseline serum urate was measured using a colorimetric assay on a Cobas 311 analyzer (Roche, Basel, Switzerland) in a sample of REGARDS study participants following a case-cohort design (14 (link)). Specifically, serum urate was measured in a sample of 1,104 REGARDS study participants randomly selected using an age-sex-race-stratified sampling approach (i.e., the random sub-cohort), and in all participants who experienced sudden cardiac death without a prior CHD event (n=435) or a CHD event excluding sudden cardiac death (n=1,612) through December 31, 2013 (i.e., the cases). After excluding participants with a history of CHD and those with missing serum urate at baseline, the final analytic dataset for the current analysis included 840 REGARDS study participants from the random sub-cohort, 235 participants with sudden cardiac death, and 851 participants with incident CHD (Figure 1).
Colantonio L.D., Reynolds R.J., Merriman T.R., Gaffo A., Singh J.A., Plante T.B., Chaudhary N.S., Armstrong N.D., Soliman E.Z., Curtis J.R., Bridges SL J.r., Lang L., Howard G., Safford M.M., Saag K.G., Muntner P, & Irvin M.R. (2021). Higher serum urate levels are associated with an increased risk for sudden cardiac death. The Journal of rheumatology, 48(11), 1745-1753.
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