Amx 300 mhz spectrometer

Manufactured by Bruker

The AMX 300 MHz spectrometer is a nuclear magnetic resonance (NMR) instrument designed for high-resolution spectroscopy. It operates at a frequency of 300 MHz and is capable of analyzing a wide range of sample types, including liquids, solids, and semi-solids. The core function of the AMX 300 MHz spectrometer is to provide detailed structural and chemical information about the sample under investigation.

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Lab products found in correlation

240 b microanalyser, by PerkinElmer (1 mentions) Axs d8 advance, by Bruker (1 mentions) Avance 3 400 mhz spectrometer, by Bruker (1 mentions) Pro star system, by Bio-Rad (1 mentions) 1706 uv vis detector, by Agilent Technologies (1 mentions) C18 column, by Agilent Technologies (1 mentions) Golden gate atr, by Specac (1 mentions) Unity plus 400 mhz, by Bruker (1 mentions) Silica gel 60 f254, by Merck Group (1 mentions) Ftir spectrophotometer, by Bruker (1 mentions) Autoflex 3 maldi tof, by Bruker (1 mentions) Ifs 66 ftir spectrophotometer, by Bruker (1 mentions)

5 protocols using amx 300 mhz spectrometer

Synthesis and Characterization of Chemical Compounds

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Starting materials and reagents were obtained from commercial suppliers and were used without purification. All melting points were determined on a Stuart SMP11 melting points apparatus and are uncorrected (East Yorkshire, UK). Electron ionization mass spectra were obtained by a Fisons QMD 1000 mass spectrometer (70 eV, 200 mA, ion source temperature 200 °C) (Loughborough, UK). Samples were directly introduced into the ion source. Found mass values are in agreement with theoretical ones. Melting points, yield of reactions and the analytical and descriptive data of derivatives are reported in Table 1.
¹H-NMR (Table 2) were registered on a Bruker AMX 300 MHz spectrometer (Billerica, MA). All samples were measured in CDCl₃. Chemical shifts are reported referenced to the solvent in which they were measured. Coupling constants J are expressed in Hz. Elemental analyses were obtained on a Perkin-Elmer 240 B microanalyser (Waltham, MA). Analytical data of the synthesised compounds are in agreement within ±0.4% of the theoretical values. TLC chromatography was performed using silica gel plates (Merck F 254, Kenilworth, NJ), spots were visualised by UV light.

Meleddu R., Distinto S., Cirilli R., Alcaro S., Yanez M., Sanna M.L., Corona A., Melis C., Bianco G., Matyus P., Cottiglia F, & Maccioni E. (2017). Through scaffold modification to 3,5-diaryl-4,5-dihydroisoxazoles: new potent and selective inhibitors of monoamine oxidase B. Journal of Enzyme Inhibition and Medicinal Chemistry, 32(1), 264-270.

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Detailed Characterization of Metal-Organic Frameworks

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¹H NMR spectra were collected on a Bruker AMX 300 MHz spectrometer and referenced to residual dimethyl sulfoxide (δ = 2.50 ppm). Powder X-ray diffraction (PXRD) patterns were collected with a laboratory Bruker AXS D8 Advance diffractometer with Cu Kα radiation (λ = 1.5418 Å) or at the Advanced Photon Source with synchrotron radiation (λ = 0.45399 Å), as specified in the figure captions. Additional details for synchrotron PXRD experiments under controlled atmospheres are given in Supporting Information Section 15. All synthetic manipulations were carried out under air unless noted otherwise. All solvents and reagents, including diamines, were purchased from commercial sources and used without further purification unless otherwise noted. The linker H₄dobpdc was purchased from Hangzhou Trylead Chemical Technology Co. The linker H₄dotpdc was prepared according to the literature procedure.^{53 (link)} The metal–organic frameworks Mg₂(dobpdc),^{51 (link)} Mn₂(dobpdc),^{52 (link)} Ni₂(dobpdc),^{52 (link)} Co₂(dobpdc),^{52 (link)} Zn₂(dobpdc),^{61 (link)} and Mg₂(dotpdc)^{53 (link)} were prepared according to literature procedures (Supporting Information Section 1). Ultrahigh purity (>99.998%) gases were used for all adsorption experiments.

Siegelman R.L., Milner P.J., Forse A.C., Lee J.H., Colwell K.A., Neaton J.B., Reimer J.A., Weston S.C, & Long J.R. (2019). Water Enables Efficient CO2 Capture from Natural Gas Flue Emissions in an Oxidation-Resistant Diamine-Appended Metal–Organic Framework. Journal of the American Chemical Society, 141(33), 13171-13186.

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Synthetic Methods and Characterization of Compounds 1-14

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Details of synthetic methods for compounds 1-11 are reported in the Supplementary Materials. 1 H and 13 C { 1 H} NMR spectra were recorded on a Bruker Avance III 400 MHz spectrometer and on a Bruker AMX 300 MHz spectrometer. High resolution mass spectra (HRMS) were recorded on an ESI-TOF Mariner from Applied Biosystems using electrospray ionization (ESI). The purity profile of the compounds was assayed by HPLC using a Varian Pro-Star system equipped with a Biorad 1706 UV-VIS detector and an Agilent C-18 column (5 μm, 4.6 × 150 mm). IR spectra were recorded on a PerkinElmer -Spectrum BX FTIR Spectrometer (compound 1) or on a Bruker Equinox 55 FTIR equipped with a single reflection diamond Specac's Golden Gate™ ATR (compounds 2-11).
Compounds 12-14 were purchased from VITAS-M Laboratory.
All compounds were negative as PAINS or aggregators when tested on dedicated web servers [36] [37] .

Dalle Vedove A., Zonta F., Zanforlin E., Demitri N., Ribaudo G., Cazzanelli G., Ongaro A., Sarno S., Zagotto G., Battistutta R., Ruzzene M, & Lolli G. (2020). A novel class of selective CK2 inhibitors targeting its open hinge conformation. European journal of medicinal chemistry, 195.

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Ultrasound-assisted Organic Synthesis

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Most the chemicals were purchased from SigmaeAldrich (St. Louis, MO, USA), Merck (Berlin, Germany) or Alfa-Aesar (Ward Hill, MA, USA). Reactions in ultrasound bath were performed in a Unique EM-804 TGR instrument, with a frequency of 40 kHz and a nominal power of 180 W, and without external heating. Precoated aluminum sheets (silica gel 60 F254, Merck) were used for thinlayer chromatography (TLC) and spots were visualized under UV light. Elemental analysis was performed with a Carlo Erba instrument model E-1110. IR spectra in KBr pellets were acquired at Bruker FT-IR spectrophotometer. 1 H and 13 C NMR were recorded on a Uni-tyPlus 400 MHz and Bruker AMX-300 MHz spectrometer, using DMSO-d 6 as a solvent and trimethylsilane (TMS) as the internal standard. Splitting patterns were defined as; s, singlet; d, doublet; dd, double doublet; t, triplet; q, quartet; m, multiplet. Chemical shift values were given in ppm. DEPT was employed to confirm the carbon assignment.

Espíndola J.W., Cardoso M.V., Filho G.B., Oliveira E Silva D.A., Moreira D.R., Bastos T.M., Simone C.A., Soares M.B., Villela F.S., Ferreira R.S., Castro M.C., Pereira V.R., Murta S.M., Sales Junior P.A., Romanha A.J, & Leite A.C. (2015). Synthesis and structure-activity relationship study of a new series of antiparasitic aryloxyl thiosemicarbazones inhibiting Trypanosoma cruzi cruzain. European journal of medicinal chemistry, 101.

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Characterization of Organic Compounds

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TLC development was conducted on 0.25 mm silica gel plates (60F 254 ). The melting points were determined on QUIMIS 340 apparatus and are uncorrected. IR spectra were measured on BRUKER IFS-66 FT-IR spectrophotometer. 1 H and 13 C NMR were recorded on Bruker AMX-300 MHz spectrometer. The chemical shifts are reported in δ units, multiplicities are given as s (singlet), d (doublet), t (triplet), m (multiplet) and dd (double doublet) and coupling constants (J) are reported in Hertz. Mass spectra were recorded on matrix-assisted laser desorption/ionization recorded with a time-of-flight mass spectrometer (MALDI-TOF) Autoflex III (Bruker Daltonics, Billerica, MA, USA).

de M Silva M., Macedo T.S., Teixeira H.M.P., Moreira D.R.M., Soares M.B.P., da C Pereira A.L., de L Serafim V., Mendonça-Júnior F.J.B., do Carmo A de Lima M., de Moura R.O., da Silva-Júnior E.F., de Araújo-Júnior J.X., de A Dantas M.D., de O O Nascimento E., Maciel T.M.S., de Aquino T.M., Figueiredo I.M, & Santos J.C.C. (2018). Correlation between DNA/HSA-interactions and antimalarial activity of acridine derivatives: Proposing a possible mechanism of action. Journal of photochemistry and photobiology. B, Biology, 189.

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