CD63-GFP floxed mice were generated in the lab by homologous recombination, as previously described 35 (link). The WT (C57B/6J, #000664), Ai14-tdTf/f reporter (#007914), ApoE-KO (B6.129P2-Apoe tm1Unc/J #002052), B6.Cg-Tg (Thy1-YFP)HJrs/J (#003782), and B6.C-Tg(CMV-Cre)1Cgn/J(#006054) mice were obtained from the Jackson Laboratory. HepaCAM knock-out (KO) mice were generated by breeding HepaCAM floxed mice (a kind gift from Dr. Cagla Eroglu at Duke University)19 (link) with CMV-Cre mice. Both male and female mice were used in all experiments. All mice were maintained on a 12 h light/dark cycle with food and water ad libitum. Care and treatment of animals in all procedures strictly followed the NIH Guide for the Care and Use of Laboratory Animals and the Guidelines for the Use of Animals in Neuroscience Research. Animal protocols used in this study have been approved by the Tufts University IACUC.
Apoe ko b6.129p2 apoe tm1unc j
Manufactured by Jackson ImmunoResearch
ApoE-KO (B6.129P2-Apoe tm1Unc/J) is a mouse strain that has a targeted mutation in the apolipoprotein E (Apoe) gene. This strain is deficient in ApoE, a protein involved in cholesterol and triglyceride metabolism. The ApoE-KO mouse is a widely used model for the study of atherosclerosis and lipid disorders.
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Lab products found in correlation
B6 cg tg thy1 yfp hjrs j, by Jackson ImmunoResearch (2 mentions)
Wt c57b 6j, by Jackson ImmunoResearch (2 mentions)
Ai14 tdtf f reporter, by Jackson ImmunoResearch (2 mentions)
B6 c tg cmv cre 1cgn j, by Jackson ImmunoResearch (2 mentions)
Tg slc1a3 cre ert 1nat j, by Jackson ImmunoResearch (1 mentions)
2 protocols using apoe ko b6.129p2 apoe tm1unc j
1
Generation and Maintenance of Transgenic Mice
2
Generating Transgenic Mouse Models
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hCD63-GFP floxed mice were generated in the lab by homologous recombination, as previously described35 (link). The WT (C57B/6J, #000664), Ai14-tdTf/f reporter (#007914), Tg(Slc1a3-cre/ERT)1Nat/J (#012586), ApoE-KO (B6.129P2-Apoe tm1Unc/J #002052), B6.Cg-Tg (Thy1-YFP)HJrs/J (#003782), and B6.C-Tg(CMV-Cre)1Cgn/J(#006054) mice were obtained from the Jackson Laboratory. HepaCAM knock-out (KO) mice were generated by breeding HepaCAM floxed mice (a kind gift from Dr. Cagla Eroglu at Duke University)19 (link) with CMV-Cre mice. Both male and female mice were used in all experiments. Both sexes were used in all studies. All mice were maintained on a 12 h light/dark cycle with food and water ad libitum.
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