12 channel head coil

Resting-state MRI, diffusion-weighted MRI, and functional MRI were performed on a 3 Tesla Siemens Tim Trio MR scanner using a 12-channel Siemens head coil. Detailed information on the data acquisition parameters can be found in Schirner et al. (2015) (link). We did not process the raw data. The data were pre-processed, and structural connectome was generated previously, using the pipeline by Schirner et al. (2015) (link).The cortical gray matter was parcellated into 34 regions of interest (ROIs) in each hemisphere following the Desikan-Killiany parcellation (Desikan et al. (2006) (link). The ROIs with their abbreviations are listed in Table S1 of the Supplemental Material.

To identify the site of the injections, anatomical MR images of the brain were acquired in a Siemens TIM TRIO 3T horizontal bore scanner. The animals were sedated with Ketamine (10 mg/Kg) and Dexdomitor (0.02 mg/kg) and were intubated and maintained on isoflurane during the scans. The scans were performed using a standard 12 channel Siemens head coil. Anatomical scans were acquired with an MPRAGE sequence using the following parameters: TR = 1800 ms, TE = 3.55 ms, FOV = 179, slice thickness: 0.7 mm, in-slice resolution: 0.5 mm.

Structural data from DTI and resting-state BOLD signal time series were acquired for 24 healthy participants (age between 18 and 33 years old, mean 25.7, 12 females, 12 males). A full description of the generation of SC and FC matrices from those data can be found in ref. 17 (link). Here, we provide a quick overview of the employed methods. Empirical data were acquired at Berlin Center for Advanced Imaging, Charité University Medicine, Berlin, Germany. For simultaneous EEG-fMRI^{55 (link), 56} , participants were asked to stay awake and keep their eyes closed. No other controlled task had to be performed. In addition, a localizer, DTI and T2 sequence were recorded for each participant. MRI was performed using a 3 Tesla Siemens Trim Trio MR scanner and a 12-channel Siemens head coil. Specifications for the employed sequences can be found in ref. 56 . For each participant anatomical T1-weighted scans were acquired. DTI and GRE field mapping were measured directly after the anatomical scans. Next, functional MRI (BOLD-sensitive, T2*-weighted, TR 1940 ms, TE 30 ms, FA 78°, 32 transversal slices (3 mm), voxel size 3 × 3 × 3 mm, FoV 192 mm, 64 matrix) was recorded simultaneously to the EEG recording.

Magnetic resonance imaging was conducted on a 3.0 T Trio scanner (Siemens, Erlangen, Germany) using a 12-channel Siemens head coil. The structural T1-weighted magnetisation prepared gradient-echo images were acquired using the following parameters: repetition time (TR) 2250 ms; echo time (TE) 3.03 ms; field of view (FOV) 256 mm; 176 sagittal slices of 1 mm thickness; flip angle = 9°, voxel size 1 × 1 × 1 mm. We screened MR images visually for artefacts and to exclude pathology.

Resting-state MRI, diffusion-weighted MRI, and functional MRI were performed on a 3 Tesla Siemens Tim Trio MR scanner using a 12-channel Siemens head coil. Detailed information on the data acquisition parameters can be found in Schirner et al. (2015) (link). We did not process the raw data. The data were pre-processed, and structural connectome was generated previously, using the pipeline by Schirner et al. (2015) (link).The cortical gray matter was parcellated into 34 regions of interest (ROIs) in each hemisphere following the Desikan-Killiany parcellation (Desikan et al. (2006) (link). The ROIs with their abbreviations are listed in Table S1 of the Supplemental Material.