All experimental animals were treated in accordance with the Association for Research in Vision and Ophthalmology Statement for Use of Animals in Ophthalmic and Vision Research, and protocols were reviewed and approved by the Johns Hopkins University Animal Care and Use Committee. Norway Brown rats were purchased from Charles River (Frederick, MD, USA). Rho/VEGF transgenic mice in which the rhodopsin promoter drives expression of VEGF165 in photoreceptors have been described (30 (link)).
Norway brown rats
Manufactured by Charles River Laboratories
Sourced in United States
Norway Brown rats are a laboratory animal model commonly used in research. They are a hardy, omnivorous rodent species that can be bred and maintained in a controlled laboratory setting.
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Lab products found in correlation
4 protocols using norway brown rats
1
Ophthalmic Research with Animal Models
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Suprachoroidal AAV Vector Injection
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All animals were treated in accordance with the Association for Research in Vision and Ophthalmology Statement for Use of Animals in Ophthalmic and Vision Research, and protocols were reviewed and approved by the Johns Hopkins University Animal Care and Use Committee. Norway Brown rats (male and female) were purchased from Charles River (Frederick, MD, USA). No sample size calculations were done in this study, but instead used sample sizes similar to those in previously published studies investigating expression after suprachoroidal injection of AAV vectors. Rats were randomly selected for different treatment groups.
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Suprachoroidal AAV Vector Injection
4
Assessing Radiation-Induced Cochlear Damage in Rats
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All rats were treated in accordance with the Guide for the Care and Use of Laboratory Animals of the National Institutes of Health (8th Edition) [40 ]. The study was reviewed and approved by the University of Miami Internal Animal Care and Use Committee (Protocol #14-020). For audiometric studies, thirty-one adult male Norway Brown rats (250–300 g; Charles River Laboratories, Inc., Wilmington, MA, USA) were randomized to receive single-fraction (0, 3, 6, 9, 12, 15, or 18 Gy) or hypo-fractionated radiation (6 Gy daily × 3 or 4 Gy daily × 5) to the left ear and followed for 24 weeks. For mechanistic studies, thirty-six neonatal Sprague Dawley rats (Charles River Laboratories, Inc., Wilmington, MA, USA) were randomized to receive 0, 6, 12, or 18 Gy to both cochleae; cochleae were harvested at 6 h for real-time polymerase chain reaction (PCR) array and 72 h for cell death assays. Three additional adult Norway Brown rats and three neonatal Sprague Dawley rats were utilized for validation of cochlear irradiation regimens.
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