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Dpdpe

Manufactured by Bachem
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Sourced in Germany

DPDPE is a synthetic cyclic pentapeptide that functions as a selective delta-opioid receptor agonist. It is commonly used in pharmacological research and development applications.

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Lab products found in correlation

Picrotoxin, by Merck Group (1 mentions) H 2535, by Bachem (1 mentions) P1675, by Merck Group (1 mentions) Damgo, by Bachem (1 mentions)

2 protocols using dpdpe

1

Analyzing Opioid and Neurotransmitter Modulation

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The MOR agonist DAMGO (H-2535, Bachem), MOR antagonist CTAP (H-3698, Bachem), delta opioid receptor agonist [D-Pen2,D-Pen5]-enkephalin (DPDPE; H-2905m, Bachem), α7 nicotinic acetylcholine receptor antagonist methyllycaconitine citrate (MLA; 1029, Tocris), AMPA antagonist NBQX (0373, Tocris), tetrodotoxin citrate (ARCD-0640, ARC Inc.), EtOH (E7148, Sigma-Aldrich), and GABAA receptor antagonist picrotoxin (P1675, Sigma-Aldrich) were used.
Muñoz B., Fritz B.M., Yin F, & Atwood B.K. (2018). Alcohol exposure disrupts mu opioid receptor-mediated long-term depression at insular cortex inputs to dorsolateral striatum. Nature Communications, 9, 1318.
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2

Nerve Injury Pharmacological Treatment

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The following substances were used: CRF, U50, 488H (Sigma Aldrich, Deisenhofen, Germany), DAMGO, DPDPE, END, ENK (Bachem, Weil am Rhein, Germany), and DYN (Tocris, Wiesbaden-Nordenstadt, Germany). All substances were dissolved in sterile water to obtain stock solutions and diluted with 0.9% NaCl. Control groups were treated with 0.9% NaCl.
All substances were injected near the nerve at the CCI site (30 μl) under brief isoflurane anaesthesia. A polyethylene tube was placed 2 mm from the tip around the 26G needle to ensure the same depth of needle insertion into the middle of the scar tissue after operation14 (link)29 (link)30 (link)33 (link).
Labuz D., Celik M.Ö., Zimmer A, & Machelska H. (2016). Distinct roles of exogenous opioid agonists and endogenous opioid peptides in the peripheral control of neuropathy-triggered heat pain. Scientific Reports, 6, 32799.
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