Ammonia aqueous solution

For mesoporous silica supports synthesis and drug delivery experiments, tetraethyl orthosilicate (TEOS, Fluka, Seelzer, Germany), poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)—Mw = 5800 (Pluronic, P123, Aldrich, Aldrich Chemical Co Inc., Milwaukee, WI, USA), trimethyl-hexadecylammonium bromide (CTAB, Alfa Aesar, Ward Hill, MA, USA), hydrochloric acid 37% (Sigma-Aldrich Co., Merck Group, Darmstadt, Germany), 25%(w/w) ammonia aqueous solution (Scharlau, Scharlab S.L., Barcelona, Spain), aminopropyl triethoxysilane (APTES, Tokyo Chemical Industry, TCI, Tokyo Japan), N-Buthyldiethanolamine (BuDEA, Sigma), absolute ethanol (Sigma-Aldrich), toluene (Riedel de Haen, Honeywell Riedel-de Haën, Seelzer, Germany), acetone (Sigma, Merck Group, Darmstadt, Germany), Irinotecan hydrochloride trihydrate (Iri, TCI), potassium dihydrogen phosphate (KH₂PO₄, Merck, Merck Group, Darmstadt, Germany), sodium hydrogen phosphate (Na₂HPO₄, Sigma–Aldrich), sodium chloride (NaCl, Sigma-Aldrich) and potassium chloride (KCl, Sigma-Aldrich) were used as received without further purification. Ultrapure deionized water (Millipore Direct-Q3UV water systems product no. C9185, Merck Group, Darmstadt, Germany with Biopack UF cartridge) was used in all experiments.

MCM-41 hexagonal structured silica, 36.5–38 wt.% hydrochloric acid, poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (Pluronic P123, average molecular weight 5800), poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol) (Pluronic F127, average molecular weight 12,600), potassium hydroxide, 98% sulfuric acid, sodium chloride, 1,3,5-trimethylbenzene (TMB), toluene, ethanol were purchased from Sigma-Aldrich (Merck Group, Darmstadt, Germany), 25 wt.% ammonia aqueous solution from Scharlau (Scharlab S.L., Barcelona, Spain), trimethylhexadecylammonium bromide (CTAB, Alfa Aesar, Ward Hill, MA, USA), and tetraethyl orthosilicate, (TEOS, Fluka, Seelzer, Germany). All organosilanes: (3-aminopropyl)triethoxysilane (APTES, 95%), (2-cyanoethyl)triethoxysilane (CETES, 97%), (3-isocyanatopropyl)triethoxysilane (ICPTES, 95%), triethoxyphenylsilane (TEPS, 98%), (3-mercaptopropyl)triethoxysilane (MPTES, 95%), and toluene (anhydrous, 99.8%) were acquired from Sigma-Aldrich and used without further purification. Resveratrol (≥99% purity) was purchased from Evolva SA (Reinach, Switzerland), and ultrapure deionized water (Millipore Direct-Q3UV with Biopack UF cartridge, Merck Group, Darmstadt, Germany) was used in all experiments.