Hypnomidate

Manufactured by Johnson & Johnson

Sourced in Belgium

Hypnomidate is a laboratory equipment product designed for use in controlled environments. It serves the core function of inducing a state of hypnosis or altered consciousness in test subjects or experimental models. The product's technical specifications and intended applications are limited to the information provided here.

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Lab products found in correlation

6 0 silicon coated monofilament, by Doccol (3 mentions) S ketamine, by Pfizer (2 mentions) Haldid, by Johnson & Johnson (2 mentions) Dormicum, by Roche (1 mentions) Sevoflurane, by Abbvie (1 mentions) Stresnil, by Johnson & Johnson (1 mentions) Thermostatically controlled warming pad, by Fine Science Tools (1 mentions) Sevorane, by Abbott (1 mentions) Dolethal, by Vetoquinol (1 mentions) Vetergesic, by Ceva (1 mentions)

6 protocols using hypnomidate

Chronic Indwelling Jugular Catheter Implantation in Rats

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We transiently anesthetized rats with isoflurane gas (induction: 4%) to inject a mixture of ketamine and xylazine (80 mg/kg, Virbac and 10 mg/kg, Bayer; i.p.). Anesthetized rats were implanted with indwelling silastic catheter into the right jugular vein, as previously described 52 . The distal end of the catheter exited the skin in the middle of the back via a metal guide cannula. After surgery, rats were allowed to recover for a period of at least 7 days before starting behavioral testing. After surgery and during the whole duration of the experimental procedures, catheters were flushed daily with a prophylactic treatment of an antibiotic (Amoxicillin, 90 mg/kg/day) dissolved in a sterile heparinized saline NaCl 0,09% (B.
Braunhéparine choay® 240 UI/ml). If necessary, catheter patency was checked by administering 0.15 ml of the short-acting non-barbiturate anesthetic Etomidate (Hypnomidate 2 mg/ml, Janssen) through the catheter.

Lenoir M., Bondi I., Clémenceau L., Nondier I., Ballé M., Jacques S., Duché A., Canestrelli C., Martin‐Lannerée S., Mouillet‐Richard S., Gunnersen J.M., Ahmed S.H., Marie N., & Noble F. (2021). Inhibition of striatal SEZ6 by miR-3594-5p is a drug-specific marker for late-stage heroin intake escalation.

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Anesthesia and Surgical Procedure Protocol

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The animals were pre-medicated with Azaperone (Stresnil, 0.1 mL/kg, Janssen Pharmaceutica, Belgium) and Midazolam (Dormicum, 0.1 mL/kg, Hoffmann-La Roche AG, Switzerland) administrated subdermally. By an intravenous access was gained through the auricular vein general anesthesia was established with etomidate (Hypnomidate, 0.25 mL/kg, Janssen Pharmaceutica, Belgium), and a standard tracheal tube, size 6.5, was inserted. General anesthesia was maintained with Sevoflurane® (3 %, AbbVie, Denmark) and fentanyl (0.175 mL/kg/h, Hameln pharmaceuticals, Germany). Prior to the surgery, the animal was treated with prophylactic antibiotics (Penicillinprokain, Ceva Sante Animale, France) 0.03 mL/kg).

Christensen B.B., Foldager C.B., Olesen M.L., Vingtoft L., Rölfing J.H., Ringgaard S, & Lind M. (2015). Experimental articular cartilage repair in the Göttingen minipig: the influence of multiple defects per knee. Journal of Experimental Orthopaedics, 2, 13.

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Rodent Ischemic Stroke Model Protocol

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Surgical procedures were generally performed under deep anesthesia using intraperitoneally applied etomidate (33 mg/kg body weight, Hypnomidate, Janssen-Cilag, Neuss, Germany), which sufficiently lasts for at least 20 min. According to the standard operation procedure suggested by Dirnagl and co-workers [14 ], the duration of surgical procedures was kept below 15 min. Ischemia was induced according to Longa et al. [40 (link)] with minor modifications as described before in detail [46 (link)]. In brief, a highly standardized and silicon-coated 6–0 monofilament (Doccol Corporation, Redlands, CA, USA) was inserted into the right external or common carotid artery, moved through the internal carotid artery towards the middle cerebral artery until bending was observed or resistance felt. To further standardize the procedure and in order to ensure sufficient occlusion, the diameter of the filament coating was adapted to the weight of the respective animals thereby normalizing for differing vascular calibers. In the model of tMCAO, animals were subjected to a second dose of etomidate to allow filament removal 60 min after ischemia induction. All procedures during anesthesia involved monitoring and adjusting of the body temperature to 37 °C using a rectal probe in combination with a thermostatically controlled warming pad (Fine Science Tools, Heidelberg, Germany).

Krueger M., Mages B., Hobusch C, & Michalski D. (2019). Endothelial edema precedes blood-brain barrier breakdown in early time points after experimental focal cerebral ischemia. Acta Neuropathologica Communications, 7, 17.

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Anesthesia and Analgesia Protocol for Animal Research

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For premedication, the animals received an intramuscular injection with ketaminol (5 mg/kg; S-ketamine, Pfizer, Berlin, Germany) and midazolam (0.5 mg/kg; Hypnomidate, Janssen-Cilag, Beerse, Belgium). The animals were intubated and anesthesia was maintained with a gas mixture of sevoflurane (Sevorane, Abbott Laboratories, Chicago, IL, USA) and O₂ 60 %. For analgesia, an intravenous infusion of fentanyl (0.025 mg/kg/h; Haldid, Janssen-Cilag, Beerse, Belgium) was maintained during the procedure.

Shiguetomi-Medina J.M., Rahbek O., Abood A.A., Stødkilde-Jørgensen H., Ramírez Garcia-Luna J.L, & Møller-Madsen B. (2016). Does radiofrequency ablation (RFA) epiphysiodesis affect adjacent joint cartilage?. Journal of Children's Orthopaedics, 10(4), 359-364.

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Evaluation of DMD mdx Rat Model

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A total of 69 DMD^mdx rats and 59 Sprague Dawley WT rats (littermates) were used in this study. They were obtained, handled and housed from the UTE IRS-UN (University de Nantes, France) and the Boisbonne Center for Gene Therapy (ONIRIS, Nantes, France). The Institutional Animal Care and Use Committee of the Région des Pays de la Loire (University of Angers, France) as well as the French Ministry for National Education, Higher Education and Research approved the protocol (authorizations #2016070618053653 and 2017040616371353). Before sacrifice, animals received a subcutaneous injection of buprenorphine (0.04 mg/kg, Vetergesic, Ceva Santé Animale, Libourne, France), after 30 min rats were anesthetized by intraperitoneal injection with etomidate (16 mg/kg, Hypnomidate, Janssen-Cilag, Issy Les Moulineaux, France), delivered in 2 or 3 injections separated by 3 min, and ketamine (20 mg/kg, Imalgene 1000, Merial, Lyon, France). Animals dedicated to ex vivo skeletal muscle contractility analysis and Ca²⁺ measurements were euthanized by heart excision. Other animals were euthanized by intravenous injection of pentobarbital sodium (Dolethal, Vetoquinol, Paris, France).

Creisméas A., Gazaille C., Bourdon A., Lallemand M.A., François V., Allais M., Ledevin M., Larcher T., Toumaniantz G., Lafoux A., Huchet C., Anegon I., Adjali O., Le Guiner C, & Fraysse B. (2021). TRPC3, but not TRPC1, as a good therapeutic target for standalone or complementary treatment of DMD. Journal of Translational Medicine, 19, 519.

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General Anesthesia Procedure for Animal Studies

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All the procedures were done under general anesthesia. For premedication the animals received an intramuscular injection of ketaminol (5 mg/kg, S-ketamine, Pfizer, Berlin, Germany) and midazolam (0.5 mg/kg, Hypnomidate, Janssen-Cilag, Beerse, Belgium). Anesthesia was maintained with an intravenous infusion of propofol (5 mg/kg/h, Fresenius Kabi AB, Uppsala, Sweden) and fentanyl (0.025 mg/kg/h, Haldid, Janssen-Cilag). Before the ablation, the animals received one prophylactic intramuscular penicillin dose (1 ml/10 kg, procaine penicillin G 150 000 IU/1 ml), and then repeatedly daily for 3 days. The animals were given intramuscular flunixin (2.2 mg/kg, Finadyne Vet, Schering-Plough, Skovlunde, Denmark) for 3 days after the procedure.

Shiguetomi-Medina J.M., Møller-Madsen B, & Rahbek O. (2016). Physeal histological morphology after thermal epiphysiodesis using radiofrequency ablation. Journal of Orthopaedics and Traumatology : Official Journal of the Italian Society of Orthopaedics and Traumatology, 18(2), 121-126.

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