NAI was synthesized as previously described (20 (link)). Briefly, 137.14 mg of 2-methylpyridine-3-carboxylic acid (Sigma Aldrich, cat. 325228) were resuspended in 500 μl DMSO anhydrous (Sigma Aldrich, cat. 276855). ∼162.15 mg of 1,1’-carbonyldiimidazole (Sigma Aldrich, cat. 115533) were resuspended in 500 μl DMSO anhydrous and added dropwise to the 2-methylpyridine-3-carboxylic acid solution while constantly stirring, over a period of 5 minutes. The reaction mixture was then incubated at room temperature with constant stirring for 2 h. This mixture (assumed to represent a 1 M stock) was aliquoted in 50 μl aliquots and stored at −80°C.
2 methylpyridine 3 carboxylic acid
Manufactured by Merck Group
2-methylpyridine-3-carboxylic acid is a heterocyclic organic compound. It is a white crystalline solid with a melting point of 170-172°C. This compound is used as an intermediate in the synthesis of various pharmaceutical and agricultural products.
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2 protocols using 2 methylpyridine 3 carboxylic acid
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Synthesis and Preparation of NAI
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Synthesis and Preparation of NAI
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NAI was synthesized as previously described (Spitale et al., 2013) . Briefly, 137.14 mg of 2-methylpyridine-3-carboxylic acid (Sigma Aldrich, cat. 325228) were resuspended in 500 μl DMSO anhydrous (Sigma Aldrich, cat. 276855). ~162.15 mg of 1,1'-Carbonyldiimidazole (Sigma Aldrich, cat. 115533) were resuspended in 500 μl DMSO anhydrous and added dropwise to the 2-methylpyridine-3-carboxylic acid solution while constantly stirring, over a period of 5 minutes. The reaction mixture was then incubated at room temperature with constant stirring for 2 hours. This mixture (assumed to represent a 1 M stock) was aliquoted in 50 μl aliquots and stored at -80°C.
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