Dm1000 system

Manufactured by Leica

The DM1000 system is a versatile microscope designed for use in laboratories. It offers high-quality optics and a range of features to support various imaging and analysis applications. The core function of the DM1000 is to provide clear and detailed microscopic observations of samples.

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Lab products found in correlation

Sm 2000, by Leica (1 mentions)

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DM1000 (262 citations) DM1000 microimaging system (4 citations)

3 protocols using dm1000 system

Histological Analysis of Liver Tissue

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Liver specimens were fixed in 10% buffered formalin and embedded in paraffin. The

8 - μ m

sections were cut using a microtome (Leica SM 2000; Germany) and mounted on glass slides. Ten cross-sections from each liver were stained with Van Gieson picrofuchsin (VG) to analyze the general histoarchitecture of the tissues, the collagen structure, and histopathological changes. All sections were examined using light microscopy, on a Leica DM1000 system.

Kuznetsova D., Rodimova S., Gulin A., Reunov D., Bobrov N., Polozova A., Vasin A., Shcheslavskiy V., Vdovina N., Zagainov V, & Zagaynova E. (2019). Metabolic imaging and secondary ion mass spectrometry to define the structure and function of liver with acute and chronic pathology. Journal of Biomedical Optics, 25(1), 014508.

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Vascularization of CT26 and HT-29 Tumors

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Verification of CT26 and HT-29 vascularization was carried out by histological examination on 13^th day after tumor cells transplantation. The excised tumors were embedded in paraffin. Several cross sections (n = 3–5) were made from the tumor center. Histological preparations were stained with hematoxylin and eosin. Sections of 7 μm thickness were examined with light microscopy using Leica DM1000 system. Histopathology examination included evaluation of the percentage of tumor vessels in both tumor models.

Orlova A., Sirotkina M., Smolina E., Elagin V., Kovalchuk A., Turchin I, & Subochev P. (2018). Raster-scan optoacoustic angiography of blood vessel development in colon cancer models. Photoacoustics, 13, 25-32.

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Histological Analysis of Tumor Damage

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For histological analysis tumors were taken on either 12th (CT26) or 18th (CT26-KillerRed) days of growth (5 days after PDT). 7-µm-thick paraffin sections were stained with hematoxylin and eosin (H&E) and examined with light microscopy on Leica DM1000 system under 40× magnification. Histopathological examination included visual assessment of tumor blood vessels damage, necrotic areas and cellular morphology.

Shirmanova M.V., Lukina M.M., Sirotkina M.A., Shimolina L.E., Dudenkova V.V., Ignatova N.I., Tobita S., Shcheslavskiy V.I, & Zagaynova E.V. (2024). Effects of Photodynamic Therapy on Tumor Metabolism and Oxygenation Revealed by Fluorescence and Phosphorescence Lifetime Imaging. International Journal of Molecular Sciences, 25(3), 1703.

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