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Hydroxypropyl methylcellulose hpmc k4m

Manufactured by Dow

Hydroxypropyl methylcellulose (HPMC; K4M) is a water-soluble polymer derived from cellulose. It functions as a thickening, suspending, and stabilizing agent in various applications.

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2 protocols using hydroxypropyl methylcellulose hpmc k4m

1

Radiolabeled Zolmitriptan Formulation

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Zolmitriptan (ZT) was donated by Global Nabi Pharmaceuticals (Giza, Egypt). L-α phosphatidylcholine from soybean oil (PC) was purchased from Acros Organics (Geel, Belgium). Terpenes (fenchone, cineole, and limonene), sodium deoxycholate (SDC), and sodium dithionite were attained from Sigma-Aldrich® (St. Louis, MO). Hydroxypropyl methylcellulose (HPMC; K4M) was bought from Dow Chemical Company (Midland, MI). Disodium hydrogen phosphate, sodium chloride, potassium dihydrogen phosphate, ethanol, methanol, and chloroform were purchased from El-Nasr Pharmaceutical Chemicals Co. (Cairo, Egypt). Technetium-99 m (99mTc) elution was developed from 99Mo / 99mTc generator as (99mTcO4), Radioisotope Production Facility (RPF), Egyptian Atomic Energy Authority (EAEA) (Cairo, Egypt). Spectra Por© dialysis membrane tubing (Mol. weight cut off; 14 g/mol) was acquired from Spectrum Laboratories Inc. (California, USA). All other chemicals (analytical grade) were utilized as received.
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2

Duloxetine Hydrochloride Formulation Development

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Duloxetine hydrochloride (DUL), reboxetine (internal standard; IS) were kindly donated by EVA Pharma (Cairo, Egypt). Cholesterol (CH), sodium deoxycholate (SDC), acetonitrile (HPLC grade), brij S2 (polyoxyethylene (2) stearyl ether), span®60 (sorbitan monostearate), and Spectra Por© dialysis tubing (Mol. Wt cut off 12–14 g/mol) were bought from Sigma-Aldrich® (St. Louis, MO). Cremophor RH 40 was procured from BASF Co. (Florham Park, NJ). Chloroform, potassium dihydrogen phosphate, methanol, and sodium chloride, disodium hydrogen phosphate were acquired from El-Nasr Pharmaceutical Chemicals Co. (Cairo, Egypt). Hydroxypropyl methylcellulose (HPMC) K4M was brought from Dow Chemical Company (Midland, US). All other (analytical grade) reagents were used as provided.
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