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Infinium humanmethylation27 assay

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The Infinium HumanMethylation27 assay is a DNA methylation analysis tool developed by Illumina. It is designed to measure the methylation status of over 27,000 CpG sites across the human genome.

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Infinium assay (58 citations) Infinium HumanMethylation27 (15 citations) HumanMethylation27 (11 citations) Infinium HumanMethylation27 BeadChip assay (2 citations)

3 protocols using infinium humanmethylation27 assay

1

Genome-wide DNA Methylation Analysis

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Whole-genome DNA methylation was analysed in 145 tumour samples using the Illumina Infinium HumanMethylation27 assay as previously reported13 (link). Data from this previous study are accessible through the NCBI’s Gene Expression Omnibus series accession number GSE43298 (http://www.ncbi.nlm.nih.gov/geo).
Castro-Vega L.J., Letouzé E., Burnichon N., Buffet A., Disderot P.H., Khalifa E., Loriot C., Elarouci N., Morin A., Menara M., Lepoutre-Lussey C., Badoual C., Sibony M., Dousset B., Libé R., Zinzindohoue F., Plouin P.F., Bertherat J., Amar L., de Reyniès A., Favier J, & Gimenez-Roqueplo A.P. (2015). Multi-omics analysis defines core genomic alterations in pheochromocytomas and paragangliomas. Nature Communications, 6, 6044.
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2

Global DNA Methylation Analysis of PCC/PGL

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KRT19 methylation data was a part of global DNA methylation study performed on a 145 samples PCC/PGL collection the Illumina Infinium HumanMethylation27 assay, as described elsewhere [24 (link)].
Loriot C., Domingues M., Berger A., Menara M., Ruel M., Morin A., Castro-Vega L.J., Letouzé É., Martinelli C., Bemelmans A.P., Larue L., Gimenez-Roqueplo A.P, & Favier J. (2015). Deciphering the molecular basis of invasiveness in Sdhb-deficient cells. Oncotarget, 6(32), 32955-32965.
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3

Genome-Wide DNA Methylation Analysis in Schizophrenia

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DNA extracted from whole blood was assessed by the Illumina Infinium HumanMethylation27 Assay (27578 CpG sites) for each participant. A methylation value, β, represents the ratio of the methylated probe intensity to the total probe intensity, ranging from 0 (unmethylated) to 1(fully methylated). A series of quality control measures were applied to remove bad samples and probes, correct the batch effect, and control for confounding factors of age, sex, race, and substance use (see details in SM 2). While the goal of this study is to help understand the methylation’s impact on brain volume alteration in SZ patients, we selected 906 CpG sites associated with diagnoses by a liberal threshold (p<0.01 uncorrected) in a linear regression model using age, sex, race, alcohol use and diagnosis as regressors (see SM 5 for the full list). The residual methylation values of these sites after correction for age, sex, race, and alcohol use were further analyzed for association with brain volume.
Liu J., Julnes P.S., Chen J., Ehrlich S., Walton E, & Calhoun V.D. (2015). The association of DNA methylation and brain volume in healthy individuals and schizophrenia patients. Schizophrenia research, 169(0), 447-452.
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