Research grade plga

Manufactured by Durect

Sourced in United States

Research-grade PLGA is a high-quality polymer used in a variety of laboratory applications. It is a copolymer of lactic acid and glycolic acid that exhibits controlled biodegradability and biocompatibility. This polymer is commonly used in research settings for the development of drug delivery systems, tissue engineering, and other advanced biomaterials applications.

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Lab products found in correlation

Chloroform, by Merck Group (2 mentions) Cd19 fitc, by Thermo Fisher Scientific (1 mentions) Cd11c pe cy7, by BD (1 mentions) Ly6g pe, by BioLegend (1 mentions) Polyvinyl alcohol (pva), by Merck Group (1 mentions) Cd11b efluor450, by Thermo Fisher Scientific (1 mentions) Coumarin 6, by Merck Group (1 mentions) Ovalbumin (ova), by Merck Group (1 mentions) Atto 565 biotin, by Merck Group (1 mentions) Palmitic acid, by Merck Group (1 mentions) Gelatin, by Merck Group (1 mentions) Methylene chloride, by Thermo Fisher Scientific (1 mentions)

3 protocols using research grade plga

CpG ODN Encapsulation in PLGA Nanoparticles

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Fully phosphorothioated 3′ Type B CpG 1826 ODN was purchased from Invivogen (sequence: 5′ TCC ATG ACG TTC CTG ACG TT 3′). Poly(vinyl alcohol) (PVA) and chloroform were purchased from Sigma-Aldrich (St. Louis, MO). Research-grade PLGA (50:50, iv .55–.75 dL/g) was purchased from Durect (Pelham, AL). The following fluorochrome-conjugated antibodies were employed: CD11c-PE-Cy7 (BD Biosciences; clone HL3), Ly6C-PerCP-Cyanine5.5 (eBioscience; clone HK1.4), Ly6G-PE (BioLegend; clone 1A8), CD11b-eFluor450 (eBioscience; clone M1/70), CD19-FITC (eBioscience; clone 1D3).

Siefert A.L., Ehrlich A., Corral M.J., Goldsmith-Pestana K., McMahon-Pratt D, & Fahmy T.M. (2016). Immunomodulatory nanoparticles ameliorate disease in the Leishmania (Viannia) panamensis mouse model. Biomaterials, 108, 168-176.

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Bioconjugated CpG Immunostimulatory Nanoparticles

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Fully phosphorothioated Type B CpG 1826 ODN were synthesized by Yale Keck Facility (sequence: 5’ TCC ATG ACG TTC CTG ACG TT) and conjugated to biotin. Poly(vinyl alcohol) (PVA), palmitic acid N-hydroxy-succinimide ester, Atto 565-biotin, Coumarin 6, Ovalbumin, and chloroform were purchased from Sigma-Aldrich. Synthetic MPLA was purchased from Invivogen, avidin from Invitrogen, and research-grade PLGA (50:50, iv.55-.75 dL/g) from Durect.

Siefert A.L., Caplan M.J, & Fahmy T.M. (2016). Artificial bacterial biomimetic nanoparticles synergize Pathogen-Associated Molecular Patterns for vaccine efficacy. Biomaterials, 97, 85-96.

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Biodegradable Nanoparticle Synthesis

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Poly(vinyl alcohol), sodium deoxycholate, palmitic acid, N-hydroxysuccinimide ester, and gelatin were all purchased from Sigma-Aldrich (St Louis, MO, USA). Methylene chloride and avidin were purchased from Thermo Fisher Scientific (Waltham, MA, USA) and Invitrogen (Carlsbad, CA, USA), respectively. Research-grade PLGA (50:50, approximately 50,000 g/mol), was purchased from Durect (Pelham, AL, USA).

Saluja S.S., Hanlon D.J., Sharp F.A., Hong E., Khalil D., Robinson E., Tigelaar R., Fahmy T.M, & Edelson R.L. (2014). Targeting human dendritic cells via DEC-205 using PLGA nanoparticles leads to enhanced cross-presentation of a melanoma-associated antigen. International Journal of Nanomedicine, 9, 5231-5246.

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