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Deuterium oxide d2o

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Deuterium oxide (D2O), also known as heavy water, is a colorless, odorless, and tasteless liquid. It is an isotopic form of water in which the hydrogen atoms have been replaced by deuterium, a stable isotope of hydrogen. Deuterium oxide has a slightly higher density than regular water and a higher boiling point.

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Lab products found in correlation

Fatty acid free hsa, by Merck Group (1 mentions) Ibuprofen, by J&K Scientific (1 mentions) Warfarin sodium, by J&K Scientific (1 mentions) Dmso d6, by J&K Scientific (1 mentions) Mln8237, by Selleck Chemicals (1 mentions) Human serum albumin (hsa), by Merck Group (1 mentions)

2 protocols using deuterium oxide d2o

1

Preparation of Fatty Acid-Free HSA

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Fatty acid-free HSA was purchased from Sigma Aldrich (Milwaukee, USA) and used without further purification. BPB (purity > 99%), BPE (purity > 99%), deuterium oxide (D2O, 99.9% purity), dimethyl sulfoxide-d6 (DMSO-d6), and 5-dimethylaminonaphthalene-1-sulfonamide (DNSA) were purchased from J&K Scientific, Ltd. (Beijing, China). Dansylsarcosine (DNSS) was obtained from Heowns Biochemical Technology Co., Ltd. (Tianjin, China). All other reagents were of analytical grade and used without further purification.
Yang H., Huang Y., Liu J., Tang P., Sun Q., Xiong X., Tang B., He J, & Li H. (2017). Binding modes of environmental endocrine disruptors to human serum albumin: insights from STD-NMR, ITC, spectroscopic and molecular docking studies. Scientific Reports, 7, 11126.
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2

Protein and Drug Interaction Study

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HSA (approximately 99% and fatty acid-free) was purchased from Sigma Chemical Company (USA), and MLN8237 was purchased from Selleck (USA). Warfarin sodium, ibuprofen, deuterium oxide (D2O, 99.9% purity), and dimethyl sulfoxide-d6 (DMSO-d6) were purchased from J&K Scientific Ltd. (China). The HSA stock solution was prepared in 0.1 M PBS at pH 7.4. The MLN8237 stock solution was also prepared by dissolving an appropriate amount of the drugs in DMSO. All reagents were of analytical reagent grade, and thrice-distilled water was used throughout the experiment.
Yang H., Liu J., Huang Y., Gao R., Tang B., Li S., He J, & Li H. (2017). Domain-specific interactions between MLN8237 and human serum albumin estimated by STD and WaterLOGSY NMR, ITC, spectroscopic, and docking techniques. Scientific Reports, 7, 45514.
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