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Avicel ph 101

Manufactured by FMC Biopolymer
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Sourced in United States, Ireland, France, Belgium, India

Avicel PH-101 is a microcrystalline cellulose product. It is a white, crystalline powder derived from purified, partially depolymerized cellulose. Avicel PH-101 is used as an excipient in the pharmaceutical and food industries.

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Lab products found in correlation

Ac di sol, by FMC Biopolymer (5 mentions) Aerosil 200, by Evonik (4 mentions) Sulfuric acid h2so4 reagent grade, by Avantor (2 mentions) Pearlitol 25c, by Roquette (2 mentions) Cetyltrimethylammonium bromide ctab, by Merck Group (2 mentions) Starch 1500, by Colorcon (2 mentions) Milli q, by Merck Group (2 mentions) Avicel ph301, by FMC Biopolymer (2 mentions) Avicel ph105, by FMC Biopolymer (2 mentions) Kollidon k30, by BASF (2 mentions) Hplc grade acetonitrile, by Merck Group (2 mentions) Triethylamine tea, by Merck Group (1 mentions) Hydrochloric acid (hcl), by Thermo Fisher Scientific (1 mentions) Potassium dihydrogen phosphate, by Thermo Fisher Scientific (1 mentions) Glacial acetic acid, by Thermo Fisher Scientific (1 mentions) Sodium hydroxide (naoh), by Thermo Fisher Scientific (1 mentions) Sodium acetate, by Thermo Fisher Scientific (1 mentions) Kollicoat ir, by BASF (1 mentions) Magnesium stearate, by Merck Group (1 mentions) Magnesium stearate, by Thermo Fisher Scientific (1 mentions)

31 protocols using avicel ph 101

1

Functionalization of Microcrystalline Cellulose

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All chemicals were used as received from commercial suppliers without further purification. The microcrystalline cellulose (MCC), named Avicel PH-101®, was provided by FMC BioPolymer (Sandvika, Norway). The average particle size of Avicel PH-101® was about 50 µm. The silane coupling agent (3–mercaptopropyl)trimethoxysilane (MRPS) was purchased from Sigma-Aldrich (95%, Steinheim, Germany). All reactions with alkoxysilane were carried out in deionized water. Triethylamine (TEA) was obtained from Merck (99%, Darmstadt, Germany). Methyl ethyl ketone, acetone, and ethanol were of technical grade.
All reactions were carried out under nitrogen atmosphere and magnetic stirring in a 100 mL reaction flask equipped with a reflux condenser.
Loof D., Hiller M., Oschkinat H, & Koschek K. (2016). Quantitative and Qualitative Analysis of Surface Modified Cellulose Utilizing TGA-MS. Materials, 9(6), 415.
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2

Verapamil-Based Controlled-Release Formulations

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Verapamil hydrochloride (HCl, Safic Alcan, Puteaux, France); microcrystalline cellulose (MCC, Avicel PH 101, FMC BioPolymer, Brussels, Belgium); lactose monohydrate (Lactochem fine powder, DFE Pharma, Goch, Germany); Kollicoat SR 30D (a 30% aqueous dispersion of polyvinyl acetate, also containing small amounts of poly(vinyl pyrrolidone) and sodium lauryl sulfate) and Kollicoat IR (polyvinyl alcohol-polyethylene glycol graft copolymer) (BASF, Ludwigshafen, Germany); two analogues of fluorescein: Anionic Oregon Green 488 dextran (10,000 MW, Invitrogen, Carlsbad, CA, USA) and anionic 2′,7′-bis-(2-carboxyethyle)-5-(and-6)-carboxyfluorescein (BCECF) dextran (10,000 MW, Invitrogen). Sodium acetate, acetic acid glacial, potassium dihydrogen phosphate, hydrochloric acid and sodium hydroxide (pellets, Fisher Scientific, Illkirch, France).
Fahier J., Vukosavljevic B., De Kinder L., Florin H., Goossens J.F., Windbergs M., Siepmann F., Siepmann J, & Muschert S. (2021). Towards a Better Understanding of Verapamil Release from Kollicoat SR:IR Coated Pellets Using Non-Invasive Analytical Tools. Pharmaceutics, 13(10), 1723.
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3

MCC Functionalization with Glutaraldehyde

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Microcrystalline cellulose (MCC) powder was supplied by FMC BioPolymer (Avicel-PH101). Sulfuric acid (H2SO4) Reagent Grade (95–97%) was procured from VWR Chemicals-USA. Ethanol and the 25 wt.% glutaraldehyde aqueous solution were purchased from Sigma Aldrich-USA. All chemicals were used as received without further modifications.
Aburabie J, & Hashaikeh R. (2022). Breaking and Connecting: Highly Hazy and Transparent Regenerated Networked-Nanofibrous Cellulose Films via Combination of Hydrolysis and Crosslinking. Nanomaterials, 12(15), 2729.
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4

Formulation and Characterization of Paracetamol-Zinc Sulfate Tablets

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Paracetamol and zinc sulfate, pharmaceutical grades (Fagron, Newcastle, UK), microcrystalline cellulose (Avicel® PH101, FMC Biopolymer, Girvan, UK), crospovidone (Polyplasdone® XL, FMC Biopolymer, Girvan, UK), sodium stearyl fumarate (FMC Biopolymer, Girvan, UK), lactose (SuperTab 14SD), sodium starch glycollate (Explotab CLV, Mendell GmbH, Volklingen, Germany); sodium croscarmellose (Ac-Di-Sol, FMC Biopolymer, Girvan, UK; mannitol, (Pearlitol® 200SD Roquette, UK), magnesium stearate, technical grade (Sigma Aldrich, Dorset, UK); Buxton® bottled water, Buxton, UK; Aptamil® 1 first milk, ready-to-feed (Nutricia, Trowbridge, UK).
Orubu S., Kendall R.A., Sheng Y, & Tuleu C. (2022). Evaluating the Taste Masking Ability of Two Novel Dispersible Tablet Platforms Containing Zinc Sulfate and Paracetamol Reconstituted in a Breast Milk Substitute. Pharmaceutics, 14(2), 420.
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5

Copovidone-based Pharmaceutical Formulations

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Two types of copovidone grades PS630 and PS630U were supplied by Ashland, Inc. (Lexington, KY, USA). QF was obtained from RIA International LLC (East Hanover, NJ, USA). Avicel PH® 101 (microcrystalline cellulose) and Ac-Di-Sol® (croscarmellose sodium) were gift samples from FMC Biopolymer (Walnut Street, PA, USA); magnesium stearate and Aerosil® 200 (colloidal silica) were purchased from Alfa Aesar (Ward Hill, MA, USA). All other chemicals used were of analytical reagent grade.
Butreddy A., Sarabu S., Bandari S., Batra A., Lawal K., Chen N.N., Bi V., Durig T, & Repka M.A. (2021). Influence of Plasdone™ S630 Ultra—an improved copovidone on the processability and oxidative degradation of quetiapine fumarate amorphous solid dispersions prepared via hot-melt extrusion technique. AAPS PharmSciTech, 22(5), 196.
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6

Preparation of Nicotine-MCC Premix

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Example 3

Preparation of Nicotine MCC Premix

A nicotine-MCC premix is made by adding first adding free nicotine to propylene glycol (PG) to obtain a 20% solution of nicotine in propylene glycol. Then, 50 grams of the nicotine-propylene glycol solution is added to 50 gram of microcrystalline cellulose provided as Avicel PH 101 from FMC Biopolymer. The nicotine-propylene glycol solution and the microcrystalline cellulose are then mixed in a Kitchenaid mixer operated at about 30 RPM for about 30 minutes at room temperature. Finally, the obtained mixture of the nicotine-propylene glycol solution and the microcrystalline cellulose is equilibrated for about 60 minutes in a sealed container.

US10485247B2. Chewing gum comprising nicotine (2019-11-26). Fertin Pharma A/S [DK]. Inventors: Jesper Neergaard [DK].
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7

Controlled Release Formulation Development

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l-Carnitine Base (Kaiyuan Hengtai Chemical Co. Ltd., China); Croscarmellose sodium “Ac-Di-Sol” and microcrystalline cellulose “Avicel PH 101 and Avicel PH 112” (FMC biopolymer, Ireland); Magnesium stearate (Peter Greven, Malaysia); Polyvinylpyrrolidone K30 “Povidone K30” (Fluka, USA); Colloidal silicon dioxide “Aerosil 200” (Evonik Degussa, Germany); Aqualon ® Ethylcellulose N 100 (Ashland, USA); Ethocel ® Standard 20 Premium (Dow Chemicals, USA); Span 80 (Sorbitan monooleate) (Loba Chemie, India); Acetonitrile HPLC grade (Merck, Germany); Potassium dihydrogen phosphate, Phosphoric acid, Liquid Paraffin, Acetone and Hexane (El-Nasr Chemicals Co., Egypt).
Hegazy M.M., Badawi A.A., El-Nabarawi M.A., Eldegwy M.A, & Louis D. (2023). One Factor at a Time and factorial experimental design for formulation of l-carnitine microcapsules to improve its manufacturability. Heliyon, 10(1), e23637.
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8

Microcrystalline Cellulose Surface Modification

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Microcrystalline cellulose (MCC) powder was supplied by FMC BioPolymer (Avicel-PH101, Philadelphia, PA, USA), 95% Sulfuric acid (H2SO4) Reagent Grade was procured from VWR Chemicals (Randor, PA, USA), 25 wt.% glutaraldehyde aqueous solution was purchased from Sigma-Aldrich (St. Louis, MO, USA).
Aburabie J., Lalia B, & Hashaikeh R. (2021). Proton Conductive, Low Methanol Crossover Cellulose-Based Membranes. Membranes, 11(7), 539.
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9

Rapidly Disintegrating Tablet Formulation

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Mefenamic acid (SIGMA, St. Louis, MO, USA) and acetylsalicylic acid (ASA) (Lot: W004649, Glatt GmbH, Binzen, Germany) were selected as a model compound to prepare rapidly disintegrating tablets. d-mannitol (Pearlitol 25C, Roquette, Lestrem, France) and microcrystalline cellulose (Avicel PH-101, FMC bioPolymer, Philadelphia, PA, USA) were used as diluents, and croscarmellose sodium (Ac-Di-Sol, FMC bioPolymer, Philadelphia, PA, USA) was used as a disintegrant. Hydroxypropyl cellulose (HPC SL, NIPPON SODA, Tokyo, Japan) was a binder, and magnesium stearate (Peter Greven GmbH & Co, Bad Münstereifel, Germany) as a lubricant was also selected. Polycaprolactone (1639, Abifor, Zurich, Switzerland) was used for the inert 2nd layer of the triple-layer tablet. Cetyltrimethylammonium bromide (CTAB) (Merck, Kenilworth, NJ, USA) was used as a surfactant for dissolution tests.
Yokoyama R., Kimura G., Huwyler J., Hosoya K.I, & Puchkov M. (2020). Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets. Pharmaceutics, 12(6), 495.
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10

Direct Compression ODT Formulation

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The ready to use co-processed excipient designed for ODT direct compression, i.e. F-MELT® type C (Fuji Chemical Industry, Japan) was kindly provided by Harke Pharma GmbH. Kollidon CL (BASF, Germany) was used as a superdisintegrant, microcrystalline cellulose – Avicel PH-101 (FMC Biopolymer) as a filler, and magnesium stearate (POCh, Poland) as a lubricant.
Brniak W., Jachowicz R, & Pelka P. (2015). The practical approach to the evaluation of methods used to determine the disintegration time of orally disintegrating tablets (ODTs). Saudi Pharmaceutical Journal : SPJ, 23(4), 437-443.
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