Avicel ph102

Manufactured by DuPont

Sourced in France, Germany, United States

Avicel®PH102 is a microcrystalline cellulose product manufactured by DuPont. It is a fine, white, odorless powder with a particle size distribution designed for use as a direct compression excipient in pharmaceutical and nutraceutical formulations.

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Lab products found in correlation

Magnesium stearate, by Evonik (1 mentions) Avicel ph101, by DuPont (1 mentions) Ac di sol, by DuPont (1 mentions) Eudragit s100, by Evonik (1 mentions) Magnesium stearate, by Thermo Fisher Scientific (1 mentions) Parafilm, by Thermo Fisher Scientific (1 mentions) α lactose monohydrate, by Merck Group (1 mentions) Polyvinyl alcohol (pva), by Merck Group (1 mentions) Kollicoat ir, by BASF (1 mentions) Spray dryer model b 290, by Büchi (1 mentions)

3 protocols using avicel ph102

Formulation and Characterization of Multivitamin Capsules

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Riboflavin, nicotinic acid, and ascorbic acid were provided by DSM Nutritional Products AG (DSM Nutritional Products AG, Kaiseraugst, Switzerland). Microcrystalline cellulose (Avicel^®PH101 and Avicel^®PH102, DuPont, Paris, France), a mixture of calcium hydrogen phosphate dihydrate, sodium starch glycolate and silicon dioxide (94:5:1) (Fagron, Capelle aan den IJsel, The Netherlands), magnesium stearate (Spruyt Hillen, Capelle aan den IJsel, The Netherlands), silicon dioxide (Spruyt Hillen, Capelle aan den IJsel, The Netherlands), methacrylic acid-methyl methacrylate copolymer 1:2 (Eudragit^® S100, Evonik industries AG, Essen, Germany), croscarmellose sodium (Ac-di-Sol^®, DuPont, Paris, France), talc (Duchefa Farma, Haarlem, The Netherlands), Polyethylene glycol 6000 (VWR, Amsterdam The Netherlands), acetone (Duchefa Farma, Haarlem, The Netherlands), red gelatin capsules size 0 (Spruyt Hillen, Capelle aan den IJsel, The Netherlands), and purified water were used for the production of the capsules. Riboflavin, nicotinic acid, and ascorbic acid were all of food grade, the other ingredients were pharmacopoeia grade (Ph. Eur. or USP/NF).

Ahmed A.A., Otten A.T., Gareb B., Huijmans J.E., Eissens A.C., Rehman A., Dijkstra G., Kosterink J.G., Frijlink H.W, & Schellekens R.C. (2023). Capsules with Ileocolonic-Targeted Release of Vitamin B2, B3, and C (ColoVit) Intended for Optimization of Gut Health: Development and Validation of the Production Process. Pharmaceutics, 15(5), 1354.

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Polymer-based Excipient Formulation Development

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Sodium polyacrylate was purchased from Magnacol Ltd. (Newtown, Wales). Magnesium stearate, parafilm, and double-sided polytetrafluoroethylene (PTFE) adhesive were purchased from Fischer Scientific (Loughborough, UK). The polyvinyl alcohol–polyethylene glycol graft copolymer (Kollicoat^® IR, denoted as KIR) was provided by BASF GmbH (Ludwigshafen, Germany). Albumin, α-lactose monohydrate, gelatin type A from porcine (bloom strength 90), λ-carrageenan from red seaweed (denoted as λ-C), hydroxypropyl methylcellulose (HPMC; grade 2910 and average M_w of 8000 Da), and polyvinyl alcohol (referred to as PVA; average M_w 31,000 of Da and 98–99% hydrolyzed) were all purchased from Sigma-Aldrich, (Poole, UK). Potassium phosphate, sodium fluoride, and calcium chloride were purchased from RM Marketing (Essex, UK). Aerosil^® 200 was from Evonik GmbH, (Wesseling, Germany), and Avicel^® PH102 was from DuPont (Delaware, USA). Propyl-methacrylate-polyvinyl acetate phthalate (PMPP) clear resin was obtained from Formlabs GmbH, Germany. Opadry^® EZ (referred to as OEZ) formulations were obtained from Colorcon (Colorcon Ltd., Dartford, UK).

Ershad A.L., Rajabi-Siahboomi A., Missaghi S., Kirby D, & Mohammed A.R. (2021). Multi-Analytical Framework to Assess the In Vitro Swallowability of Solid Oral Dosage Forms Targeting Patient Acceptability and Adherence. Pharmaceutics, 13(3), 411.

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Fermented Jackfruit Pulp Powder Production

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Microcrystalline cellulose used was of pharmaceutical grade (Avicel PH102, DuPont, US). The fermented jackfruit pulp beverage was obtained from MARDI. The fermented jackfruit pulp beverage was produced using a symbiotic culture of bacteria and yeast under controlled fermentation process, which is a propriety process of the Malaysia Agricultural Research and Development Institute (MARDI). The fermented jackfruit pulp powder was formed through spray drying (Spray Dryer model B-290, Buchi, Malaysia) of this fermented jackfruit pulp beverage containing 8% w/w maltodextrin (DE10) and 2% w/w arabic gum using an inlet air temperature of 170⁰C and airflow rate of 35 m 3 hr -1 . The spray drying conditions were obtained from preliminary unpublished work to convert the fermented jackfruit pulp beverage into powder form.

Azman N., Koh S.P., Hamidi F.W.A., Anuar M.S., & Tahir S.M. (2021). Particle size, compaction characteristic and tablet strength of spray-dried fermented jackfruit pulp - microcrystalline cellulose binary powder mixture. Food Research, 5(S1), 8-13.

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