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Tenofovir alafenamide

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Tenofovir alafenamide is a nucleotide reverse transcriptase inhibitor (NRTI) used as a component of antiretroviral therapy to treat HIV-1 infection. It is an oral antiviral medication that inhibits the replication of the HIV virus.

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Lab products found in correlation

Emtricitabine, by Gilead Sciences (6 mentions) Abacavir, by Gilead Sciences (3 mentions) Dolutegravir, by Gilead Sciences (3 mentions) Lamivudine, by Gilead Sciences (3 mentions) Tenofovir disoproxil fumarate, by Gilead Sciences (3 mentions) Raltegravir, by Gilead Sciences (3 mentions) Atazanavir, by Gilead Sciences (2 mentions) Bevirimat, by Gilead Sciences (1 mentions) Remdesivir, by Gilead Sciences (1 mentions) Lenacapavir, by Gilead Sciences (1 mentions) Efavirenz, by Gilead Sciences (1 mentions) Danoprevir, by Selleck Chemicals (1 mentions) Ym 53403, by Gilead Sciences (1 mentions) Azidothymidine azt, by Merck Group (1 mentions) Puromycin, by Merck Group (1 mentions) Elvitegravir, by Gilead Sciences (1 mentions)

7 protocols using tenofovir alafenamide

1

Particle Size Analysis of Tolbutamide and Tenofovir Alafenamide

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Two drugs were assessed for particle size: tolbutamide (TBM) (Sigma Aldrich) and tenofovir alafenamide (Gilead Sciences, Inc.) with urocanic acid (Fisher Scientific)[31 ] (TAF-UA). Approximately 20 mg of each drug was individually allocated in two vials. Two (2) mL of PBS was added to one vial, and 2 mL of PBS 0.05% Tween 20 was added to the other. Each vial was sonicated with a sonication probe at 50 amps for 4 minutes. Afterwards, 10 μL of drug solution was placed on a microscope slide, using wedge slide technique. Slides were imaged at 40 × magnification using EVOS microscope on a 4 mm × 4 mm area (total 108 images per sample). Another 10 μL of drug solution was placed on a flat silica substrate onto an SEM holder and sputtered with 7 nm of iridium. SEM images were taken using FEI Nova NanoSEM 230 ultra-high resolution, at the HMRI Microscope Core. Images were analyzed and particle size distribution determined using ImageJ and MATLAB®.
Di Trani N., Pons-Faudoa F.P., Sizovs A., Shelton K.A., Marzinke M.A., Nehete P.N, & Grattoni A. (2021). Extending drug release from implants via transcutaneous refilling with solid therapeutics. Advanced therapeutics, 5(2), 2100214.
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2

Antivirals and HIV Plasmid Protocol

Cited 1 time
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The antivirals Emtricitabine (FTC), Tenofovir Disoproxil Fumarate (TDF), Raltegravir (RAL), abacavir (ABC), dolutegravir (DOL), lamivudine (3TC), tenofovir alafenamide (TAF) were a gift from Gilead Sciences or were obtained from pharmacy. HIV p89.6 plasmid DNA was obtained from the NIH AIDS reagent Program. Murine chow diet with antibiotic was purchased from Envigo Teklad Diets. All other materials were purchased from commercially available sources and have been previously described in detail [15 (link)]. All lipids were purchased from Cayman Chemicals (Ann Arbor, MI, USA) and are described in detail in the Supplemental material.
Daskou M., Sharma M., Mu W., Heymans R., Ritou E., Rezek V., Hamid P., Kossyvakis A., Sen Roy S., Grijalva V., Chattopadhyay A., Papesh J., Meriwether D., Kitchen S.G., Fogelman A.M., Reddy S.T, & Kelesidis T. (2021). ApoA-I mimetics favorably impact cyclooxygenase 2 and bioactive lipids that may contribute to cardiometabolic syndrome in chronic treated HIV. Metabolism: clinical and experimental, 124, 154888.
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3

Tenofovir Alafenamide and Emtricitabine Study

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Tenofovir alafenamide (TAF) and emtricitabine (FTC) were kindly provided by Gilead Sciences, Inc. (Foster City, CA).
Chua C.Y., Jain P., Ballerini A., Bruno G., Hood R.L., Gupte M., Gao S., Di Trani N., Susnjar A., Shelton K., Bushman L.R., Folci M., Filgueira C.S., Marzinke M.A., Anderson P.L., Hu M., Nehete P., Arduino R.C., Sastry K.J, & Grattoni A. (2018). Transcutaneously refillable nanofluidic implant achieves sustained level of tenofovir diphosphate for HIV pre-exposure prophylaxis. Journal of controlled release : official journal of the Controlled Release Society, 286, 315-325.
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4

Antivirals and HIV Plasmid Protocol

Cited 1 time
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The antivirals Emtricitabine (FTC), Tenofovir Disoproxil Fumarate (TDF), Raltegravir (RAL), abacavir (ABC), dolutegravir (DOL), lamivudine (3TC), tenofovir alafenamide (TAF) were a gift from Gilead Sciences or were obtained from pharmacy. HIV p89.6 plasmid DNA was obtained from the NIH AIDS reagent Program. Murine chow diet with antibiotic was purchased from Envigo Teklad Diets. All other materials were purchased from commercially available sources and have been previously described in detail [15 (link)]. All lipids were purchased from Cayman Chemicals (Ann Arbor, MI, USA) and are described in detail in the Supplemental material.
Daskou M., Sharma M., Mu W., Heymans R., Ritou E., Rezek V., Hamid P., Kossyvakis A., Sen Roy S., Grijalva V., Chattopadhyay A., Papesh J., Meriwether D., Kitchen S.G., Fogelman A.M., Reddy S.T, & Kelesidis T. (2021). ApoA-I mimetics favorably impact cyclooxygenase 2 and bioactive lipids that may contribute to cardiometabolic syndrome in chronic treated HIV. Metabolism: clinical and experimental, 124, 154888.
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5

Transgenic Tomato-Derived Antiviral Compounds

Cited 1 time
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A concentrate of control transgenic tomatoes (EV) or a concentrate of transgenic tomatoes expressing the 6F peptide (Tg6F) were prepared and added to the diets at 0.06% by weight as described previously [11 (link)]. 4F and 6F peptides were synthesized as previously [14 (link)]. The antivirals Emtricitabine (FTC), Tenofovir Disoproxil Fumarate (TDF), Raltegravir (RAL), abacavir (ABC), dolutegravir (DOL), lamivudine (3TC), tenofovir alafenamide (TAF), FTC were either a generous gift from Gilead Sciences or were obtained from pharmacy. HIV p89.6 plasmid DNA was obtained from the NIH AIDS reagent Program. Murine chow diet with antibiotic was purchased from Envigo Teklad Diets. All other materials were purchased from commercially available sources and have been previously described in detail [24 (link)].
Daskou M., Mu W., Sharma M., Vasilopoulos H., Heymans R., Ritou E., Rezek V., Hamid P., Kossyvakis A., Sen Roy S., Grijalva V., Chattopadhyay A., Kitchen S.G., Fogelman A.M., Reddy S.T, & Kelesidis T. (2022). ApoA-I mimetics reduce systemic and gut inflammation in chronic treated HIV. PLoS Pathogens, 18(1), e1010160.
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6

Synthesis and Evaluation of HIV Inhibitors

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GS-CA1, PF74, emtricitabine (FTC), tenofovir (TFV), tenofovir alafenamide (TAF), elvitegravir (EVG), darunavir (DRV), atazanavir (ATV) and bevirimat (BVM) were synthesized at Gilead Sciences (Foster City, CA). Efavirenz (EFV), rilpivirine (RPV), dolutegravir (DTG) and raltegravir (RAL) were purchased from Toronto Research Chemicals, Curragh Chemistries, Porton Shanghai R&D Center and Expicor, respectively.
Yant S.R., Mulato A., Hansen D., Tse W.C., Niedziela-Majka A., Zhang J.R., Stepan G.J., Jin D., Wong M.H., Perreira J.M., Singer E., Papalia G.A., Hu E.Y., Zheng J., Lu B., Schroeder S.D., Chou K., Ahmadyar S., Liclican A., Yu H., Novikov N., Paoli E., Gonik D., Ram R.R., Hung M., McDougall W.M., Brass A.L., Sundquist W.I., Cihlar T, & Link J.O. (2019). A Highly Potent Long-Acting Small-Molecule HIV-1 Capsid Inhibitor with Efficacy in a Humanized Mouse Model. Nature medicine, 25(9), 1377-1384.
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7

Comprehensive Synthesis of Antiviral Compounds

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GS-9770, atazanavir (ATV), darunavir (DRV), amprenavir (APV), bictegravir (BIC), elvitegravir (EVG), lenacapavir (LEN), tenofovir alafenamide (TAF), emtricitabine (FTC), efavirenz (EFV), stavudine (d4T), the RSV control inhibitor YM-53403, and the SARS CoV-2 control inhibitor remdesivir (RDV) were all synthesized at Gilead Sciences (Foster City, CA). Ribavirin (RBV) was purchased from Combi-Blocks (San Diego, CA). The protein synthesis inhibitor puromycin and the HIV-positive control azidothymidine (AZT) were purchased from Sigma-Aldrich (St. Louis, MO). The HBV control inhibitor ND-654 was purchased from Pharmaron (Beijing, China). The HCV protease inhibitor danoprevir was purchased from Selleck Chemicals (Houston, TX). All drug stocks were prepared in 100% dimethyl sulfoxide (DMSO) and stored frozen at −20°C.
Mulato A., Lansdon E., Aoyama R., Voigt J., Lee M., Liclican A., Lee G., Singer E., Stafford B., Gong R., Murray B., Chan J., Lee J., Xu Y., Ahmadyar S., Gonzalez A., Cho A., Stepan G.J., Schmitz U., Schultz B., Marchand B., Brumshtein B., Wang R., Yu H., Cihlar T., Xu L, & Yant S.R. (2024). Preclinical characterization of a non-peptidomimetic HIV protease inhibitor with improved metabolic stability. Antimicrobial Agents and Chemotherapy, 68(4), e01373-23.
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