Ge fastlab 2 developer synthesis module

The dissolved target solution containing [⁶⁸Ga]GaCl₃ and [⁶⁸Zn]ZnCl₂ was automatically transferred to a GE FASTlab 2 Developer synthesis module for separating the gallium-68 from the target material by three solid phase extraction columns (Fig. 2). First, the target solution was pumped through a column containing 250 mg ZR resin. 15 mL of 30% HCl were used to elute remaining zinc-68 from the ZR column, while gallium-68 was eluted from the column with 8 mL of 1 N HCl. The solution containing gallium-68 was pushed through the second column containing LN resin in order to bind Fe contaminants, while the eluted [⁶⁸Ga]GaCl₃ was directly loaded onto a third column containing TK200 resin. The TK200 resin was dried by purging with nitrogen, then eluted to a product vial using 2.5 mL of 0.1 N HCl. The overall process of target dissolution and purification took approximately 35 min.
Fig. 2

ARTMS receive station (a), zinc-68 dissolution cell (b) and dissolution box (c) coupled to the GE FASTlab 2 Developer synthesis module with gallium-68/zinc-68 separation cassette installed. The [⁶⁸Ga]GaCl₃ outlet (d) was connected to the Modular-Lab PharmTracer (not shown) for automated radiolabelling of PSMA-11