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3 protocols using lncl3.6h2o

1

Anhydrous Lanthanide Chloride-Based Deep Eutectic Solvents

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LnCl3 (Ln = Nd,
Eu, Dy, Er, Yb, anhydrous, ≥99.9%), LnCl3.6H2O (Ln = Nd, Eu, Dy, Er, Yb; ≥99.9%), choline chloride
(98%), ethylene glycol (anhydrous, 99.8%), and urea (99.5%) were purchased
from Sigma-Aldrich. l-lactic acid (anhydrous, 98%) was purchased
from Alfa Aesar. All anhydrous chemicals were transferred to an Ar
atmosphere glovebox [(O2), (H2O) ≤ 5
ppm] for use and storage. choline chloride and urea were dried in
a vacuum oven (24 h, 80 °C) before being transferred into the
glovebox.
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2

Rare-earth Doped Nanoparticles for Theranostics

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The reagents oleic acid (OA) (90%), octadecene (ODE) (90%), NaOH (98%), NH4F (98%), methanol (99%), polyethylene glycol (PEG) (90%), doxorubicin (Dox), LnCl3·6H2O (Ln = Gd/Y, Yb and Er) (99.99%), C2H5OH (90%), cyclohexane (90%), capillary glass tube (CGT) (outside diameter = 120 μm), Y-type optical fiber, and polymethylmethacrylate (PMMA), were purchased from Sigma-Aldrich. Deionized water was used to prepare solutions. All other reagents were of AR grade and used directly without further purification.
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3

Synthesis of Rare-Earth Doped Nanoparticles

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LnCl 3 •6H 2 O (Ln: Y, Yb, Er >99%), Ln 2 O 3 (Ln: Y, Yb, Er, Nd >99%), oleic acid (OA, 90%), 1-octadecene (ODE, 90%), oleylamine (OM, 90%), sodium trifluoroacetate (98%) and trifluoroacetic acid (99%) were purchased from Sigma-Aldrich and used without further purification. NaOH (>98%), NH 4 F (>98%), methanol, ethanol and cyclohexane were purchased from GFS Chemical. The 20 nm β-NaYF 4 :Yb,Er nanoparticles and 20 nm β-NaYF 4 :x% Er (x: 2-100) nanoparticles were synthesized following a previous approach in the literature. 24
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