The largest database of trusted experimental protocols

Redisep 40 g column

Manufactured by Teledyne

The Redisep 40 g column is a piece of lab equipment designed for chromatographic separation. It is a column with a 40 gram capacity for purification of various compounds.

Automatically generated - may contain errors

Lab products found in correlation

7 protocols using redisep 40 g column

1

Synthesis of Furan-3-Carboxaldehyde Imine

Check if the same lab product or an alternative is used in the 5 most similar protocols
General procedure XI was followed using furan-3-carbaldehyde (19d) (1.80 mL, 20.8 mmol), butylamine (0.25 mL, 2.5 mmol), acetic acid (0.24 mL, 4.2 mmol), and 4 Å molecular sieves (200 mg) in nitromethane (21 mL). The crude product was purified via flash column chromatography (ISCO, Redisep 40 g column, 0–100% EtOAc/hexanes gradient) to afford the title compound as a yellow solid (2.9 g, quant.). Rf (1:1 EtOAc/Hex): 0.83; 1H NMR (400 MHz, CDCl3) δ 7.93 (d, J = 13.5 Hz, 1H), 7.86–7.81 (m, 1H), 7.56–7.48 (m, 1H), 7.39 (d, J = 13.5 Hz, 1H), 6.59–6.55 (m, 1H). 13C NMR (101 MHz, CDCl3) δ 147.3, 145.3, 136.7, 129.6, 118.2, 107.2. No ionization observed by HRMS.
+ Open protocol
+ Expand
2

Synthesis of 1-Methyl-1H-pyrazole-5-carbaldehyde Imine

Check if the same lab product or an alternative is used in the 5 most similar protocols
General procedure XI was followed using 1-methyl-1H-pyrazole-5-carbaldehyde (19e) (2.00 g, 18.2 mmol), butylamine (0.22 mL, 2.2 mmol), acetic acid (0.21 mL, 3.6 mmol), and 4 Å molecular sieves (200 mg) in nitromethane (18 mL). The crude product was purified via flash column chromatography (ISCO, Redisep 40 g column, 0–100% EtOAc/hexanes gradient) to afford the title compound as a yellow solid (1.7 g, 62%). Rf (1:1 EtOAc/Hex): 0.65; 1H NMR (400 MHz, CDCl3) δ 7.94 (d, J = 13.4 Hz, 1H), 7.54 (d, J = 2.2 Hz, 1H), 7.51 (d, J = 13.4 Hz, 1H), 6.66 (d, J = 2.2 Hz, 1H), 4.02 (s, 3H). 13C NMR (101 MHz, CDCl3) δ 139.4, 137.6, 133.2, 124.4, 107.5, 37.3. HRMS calcd for C6H8O2N3, 154.06110 [M + H]+; found 154.06109 [M +H]+.
+ Open protocol
+ Expand
3

Synthesis of 2-Chloroacetyl-3-Methoxyphenylacetate

Check if the same lab product or an alternative is used in the 5 most similar protocols
General procedure I was followed using methyl 2-(3-methoxyphenyl)-acetate (8c) (2.23 mL, 13.9 mmol), 1 M tin(IV) chloride in DCM (69.4 mL, 69.4 mmol), and 2-chloroacetyl chloride (4.45 mL, 55.5 mmol) in DCE (14 mL). The crude product was purified via flash column chromatography (ISCO, Redisep 40 g column, 0–50% EtOAc/hexanes gradient) to afford the title compound as a white solid (1.65 g, 46%). Rf (1:1 EtOAC/Hex): 0.66; 1H NMR (399 MHz, CDCl3) δ 7.75 (d, J = 8.7 Hz, 1H), 6.86 (dd, J = 8.7, 2.6 Hz, 1H), 6.78 (d, J = 2.6 Hz, 1H), 4.63 (s, 2H), 3.92 (s, 2H), 3.85 (s, 3H), 3.69 (s, 3H). 13C NMR (100 MHz, CDCl3) δ 191.8, 171.5, 162.8, 138.6, 132.1, 126.6, 119.1, 112.0, 55.5, 51.9, 47.1, 40.6. HRMS calcd for C12H14O4Cl, 257.05751 [M + H]+; found 257.05751 [M + H]+.
+ Open protocol
+ Expand
4

Synthesis of Thiophene-3-Carbaldehyde Derivatives

Check if the same lab product or an alternative is used in the 5 most similar protocols
General procedure XI was followed using thiophene-3-carbaldehyde (19a) (3.00 g, 26.7 mmol), butylamine (0.32 mL, 3.2 mmol), acetic acid (0.31 mL, 5.4 mmol), and 4 Å molecular sieves (300 mg) in nitromethane (27 mL). The crude product was purified via flash column chromatography (ISCO, Redisep 40 g column, 0–100% EtOAc/hexanes gradient) to afford the title compound as a yellow solid (3.3 g, 79%). Rf (1:1 EtOAc/Hex): 0.58; 1H NMR (500 MHz, CDCl3) δ 8.01 (dd, J = 13.5, 0.5 Hz, 1H), 7.73 (ddd, J = 2.5, 1.3, 0.6 Hz, 1H), 7.49 (d, J = 13.5 Hz, 1H), 7.44 (ddd, J = 5.1, 2.9, 0.7 Hz, 1H), 7.28 (ddd, J = 5.1, 1.3, 0.5 Hz, 3H). 13C NMR (126 MHz, CDCl3) δ 136.7, 132.6, 132.5, 132.2, 128.2, 125.1. HRMS calcd for C6H6O2NS, 156.01138 [M + H]+; found 156.01151 [M + H]+.
+ Open protocol
+ Expand
5

Synthesis of 2-(Thiophen-2-yl)Acetamide

Check if the same lab product or an alternative is used in the 5 most similar protocols
General procedure V was followed using 2-(thiophen-2-yl)ethan-1-amine (21f) (2.00 g, 15.7 mmol), triethylamine (3.18 mL, 31.4 mmol), and 2-chloroacetyl chloride (1.51 mL, 18.9 mmol) in DCM (57 mL). The crude product was purified via flash column chromatography (ISCO, Redisep 40 g column, 0–60% EtOAc/hexanes gradient) to afford the title compound as a red oil (2.64 g, 82%). Rf (1:1 EtOAc/Hex): 0.51; 1H NMR (500 MHz, CDCl3) δ 7.18 (dd, J = 5.2, 1.2 Hz, 1H), 6.95 (dd, J = 5.1, 3.4 Hz, 1H), 6.88–6.83 (m, 1H), 6.75 (s, 1H), 4.03 (s, 2H), 3.58 (q, J = 6.7 Hz, 2H), 3.07 (t, J = 6.7 Hz, 2H). 13C NMR (126 MHz, CDCl3) δ 165.9, 140.6, 127.2, 125.6, 124.2, 42.7, 41.1, 29.7. HRMS calcd for C8H10ONClNaS, 226.00638 [M + Na]+; found 226.00658 [M + Na]+.
+ Open protocol
+ Expand
6

Synthesis of N-Chloroacetyl-3,4-Dimethoxyphenethylamine

Check if the same lab product or an alternative is used in the 5 most similar protocols
General procedure V was followed using compound 3,4-dimethoxyphenethylamine (13) (5.59 mL, 33.1 mmol), triethylamine (9.23 mL, 66.2 mmol), and 2-chloroacetyl chloride (3.16 mL, 39.7 mmol) in dry DCM (120 mL). The crude product was purified via flash column chromatography (ISCO, Redisep 40 g column, 10–80% EtOAc/hexanes gradient) to afford the title compound as a white solid (6.32 g, 74%). Rf (1:1 EtOAc/Hex): 0.56; 1H NMR (300 MHz, CDCl3) δ 6.82 (d, J = 8.0 Hz, 1H), 6.77–6.69 (m, 2H), 6.64 (s, 0H), 4.02 (s, 2H), 3.87 (s, 3H), 3.86 (s, 3H), 3.53 (q, J = 6.9 Hz, 2H), 2.78 (t, J = 7.0 Hz, 2H). 13C NMR (75 MHz, CDCl3) δ 165.7, 149.0, 147.8, 130.8, 120.6, 111.8, 111.3, 55.9, 42.7, 41.1, 35.1. HRMS calcd for C12H17O3NCl, 258.08915 [M + H]+; found 258.08876 [M + H]+.
+ Open protocol
+ Expand
7

Synthesis of 2-Phenylethyl 3,4-Dimethoxybenzyl Ether

Check if the same lab product or an alternative is used in the 5 most similar protocols
General procedure VIII was followed using compound 15a (2.67 g, 8.11 mmol), phosphorous oxychloride (2.27 mL, 24.3 mmol), and sodium borohydride (0.64 g, 24 mmol) in acetonitrile (~40 mL) and MeOH (~10 mL). The crude product was purified via flash column chromatography (ISCO, Redisep 40 g column, 10–90% EtOAc/hexanes gradient) to afford the title compound as a white foam (1.6 g, 62% over two steps). Rf (1:1 EtOAC/Hex): 0.29; 1H NMR (300 MHz, CDCl3) δ 7.38–7.26 (m, 5H), 6.58 (s, 2H), 4.68–4.50 (m, 2H), 4.17 (dd, J = 8.2, 3.9 Hz, 1H), 3.83 (s, 3H), 3.79 (s, 3H), 3.75–3.62 (m, 2H), 3.25–3.10 (m, 1H), 3.04–2.90 (m, 1H), 2.74 (t, J = 5.8 Hz, 2H). 13C NMR (101 MHz, CDCl3) δ 147.6, 147.1, 138.0, 128.4, 127.8, 127.7, 127.7, 126.6, 111.8, 109.2, 73.3, 72.9, 55.9, 55.8, 55.0, 40.0, 29.0. HRMS calcd for C19H24O3N, 314.17507 [M + H]+; found 314.17453 [M + H]+.
+ Open protocol
+ Expand

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required

Sign up now

Revolutionizing how scientists
search and build protocols!