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7t scanner

Manufactured by Siemens
Sourced in Germany

The 7T scanner is a magnetic resonance imaging (MRI) system designed for research purposes. It generates a strong magnetic field of 7 Tesla, which allows for high-resolution imaging and detailed analysis of the human body. The 7T scanner is used to study the structure and function of the brain and other organs with exceptional clarity and precision. Its core function is to provide researchers with advanced imaging capabilities to support their scientific investigations.

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21 protocols using 7t scanner

1

Metabolite Concentrations in Frontal Cortex

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Nine healthy volunteers (three women and six men; age = 28 ± 8 years) were recruited for measurements of metabolite concentrations and relaxation times in the frontal cortex. Two of the volunteers were scanned twice. No data were excluded and all collected data were used in the analysis. All volunteers gave informed consent in accordance with procedures approved by our local institutional review board. Experiments were performed on a Siemens 7 T scanner equipped with a 32-channel receiver head coil. T1-weighted magnetization prepared rapid gradient echo (MPRAGE) images were acquired with TR = 3 s, TE = 3.9 ms, matrix = 256 × 256 × 256, and resolution = 1 × 1 × 1 mm3 to position the MRS voxel and perform tissue segmentation. For each subject, MRS data were collected from two 2 × 2 × 2 cm3 voxels in the frontal cortex. One voxel was placed in the grey matter (GM) dominant region of prefrontal cortex (PFC) and medial pregenual anterior cingulate cortex (pgACC), both of which have been implicated in several brain disorders (23 (link),24 (link)). The other voxel was placed in the white matter (WM) dominant right frontal cortex. B0 field inhomogeneities were minimized by first- and second-order shimming, achieving mean water linewidth of 11.1 Hz and 13.4 Hz for the voxels in the GM and WM regions, respectively. MRS data acquisition for each voxel lasted < 10 min.
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2

Functional Neuroimaging Acquisition Protocol

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A Siemens 7T scanner equipped with a 32-channel head coil was used in Experiment 2. Functional scans were obtained using a gradient-echo EPI sequence (54 slices, TR/TE = 2000/25ms, slice thickness = 2mm, FOV = 192 mm, flip angle = 50°, image matrix: 96×96, 343 volumes) covering the whole brain. An additional high-resolution anatomical scan was acquired in each participant (MPRAGE; TR/TE/TI=3000/3.88/1500ms, FA = 6°, FOV = 256×256mm, 192 sagittal slices, slice thickness/gap = 1.00/0.50 mm, in-plane resolution = 1×1mm). The stimuli were presented via a video projector (resolution 1024×768 pixel, 60 Hz) that projected from the head-end of the scanner onto a screen. Participants viewed the projection through mirror glasses. The data for subject 6 were acquired in two sessions; those for the other subjects were acquire in a single session.
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3

High-Resolution Functional MRI Acquisition

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Imaging data were collected on a Siemens 7T scanner with a Siemens 32-channel surface coil. Each scan session began with a high resolution T1-weighted Magnetization Prepared Rapid Gradient Echo (MPRAGE) sequence (TE = 3.88 msec; TR = 3000 msec; flip angle = 6°; matrix size = 256 X 256; voxel size = 1 mm × 1 mm x 1 mm; 192 axial slices). The functional images were acquired with a single-shot interleaved gradient-recalled echo planar imaging sequence, with slices positioned to cover all of the occipital and temporal lobes (TE = 27 msec; TR = 2000 msec; flip angle = 70°; matrix size = 126 × 126; voxel size = 1.6 mm × 1.6 mm x 1.6 mm; 43 oblique axial slices, no acceleration was used). Supplementary Figure S3B shows the fMRI scan slice coverage overlaid on a representative human brain.
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4

Postmortem Brain Imaging at 7T

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All scans of postmortem tissue were performed at Western's Centre for Functional and Metabolic Mapping on a 7T Scanner (Siemens) following a previously described imaging protocol [33 (link)]. Briefly, frontal coronal sections were selected from each fixed brain and immersed in Galden HT‐270 perfluorinated fluid in a custom‐stacking device for imaging. T1‐weighted images from a MP2RAGE sequence, with an extended T1 time to improve contrast, and FLAIR images from a T2 SPACE sequence were acquired.
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5

Human Connectome Project Diffusion MRI

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HCP3T, 90 gradient directions, 1.25 mm isotropic resolution. Data of four subjects, part of the Human Connectome Project54 , acquired using a Siemens 3 T “Connectome” scanner were used. Measurements from the 2,000 s/mm2 shell were extracted from the original dataset and used for all analyses. Processing methods are described in22 (link).
HCP7T, 60 gradient directions, 1.05 mm isotropic resolution. Five subjects part of the Human Connectome 7-Tesla (7 T) dataset were used. Data were collected a Siemens 7 T scanner55 . Measurements from the 2,000 s/mm2 shell were extracted from the original data and were used for further analyses.
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6

Multimodal Neuroimaging of Pregenual ACC

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Five healthy volunteers (three women and two men; age = 34 ± 17 years) were recruited for the study. All volunteers gave informed consent in accordance with procedures approved by our local institutional review board. Experiments were performed on a Siemens 7 T scanner equipped with a 32-channel receiver head coil. T1-weighted magnetization prepared rapid gradient echo (MPRAGE) images were acquired with TR = 3 s, TE = 3.9 ms, matrix = 256 × 256 × 256, and resolution = 1 × 1 × 1 mm3 to position the MRS voxel. For each subject, MRS data were collected twice using the proposed pulse sequence from a 2 × 2 × 2 cm3 voxel in the grey matter dominant region of pregenual anterior cingulate cortex (pgACC), which has been implicated in several psychiatric disorders (15 (link)). The MRS pulse sequence used TR = 3.5 s, TE = 56 ms, TE1 = 40 ms, Td = 15.3 ms, spectral width = 4000 Hz, number of data points = 1024, number of averages = 72, and total scan time = 4 min and 23 s. Before each MRS scan, B0 field inhomogeneities were minimized by first- and second-order shimming, achieving mean water linewidth of 11.7 Hz.
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7

High-Resolution Brain Imaging with 7T and 3T MRI

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All 92 subjects were examined with both 7 T and 3 T brain scans. A Siemens 7 T scanner was used with a custom‐built 32‐channel phased‐array head coil. A 2‐dimensional single‐echo FLASH T2*‐weighted spoiled gradient‐echo pulse sequence was applied (repetition/echo times = 1700/21.8 ms, flip angle 55°, 40 slices each on two separate slabs covering the whole supratentorial brain, field of view = 192 × 168 mm, resolution = 0.33 × 0.33 × 1.0 mm, bandwidth = 335 Hz/pixel, acquisition time for each slab 7:37 minutes). Thereafter, the two slabs were co‐registered into FreeSurfer space using a boundary‐based registration method. This methodology has been applied and detailed in previous studies.26, 27, 28The 3 T scans were acquired with the MGH‐USC Skyra CONNECTOM scanner with a custom‐built 64‐channel head coil. A 3‐dimensional T1‐weighted multi‐echo magnetization‐prepared rapid gradient‐echo (MPRAGE) sequence was acquired for FreeSurfer anatomical reconstructions (repetition/echo/inversion times = 2530/1.15/1100, 3.03, 4.89, 6.75 ms, flip angle 7°, 176 slices, field of view = 230 × 230 mm, resolution 1.0 × 1.0 × 1.0 mm, bandwidth 651 Hz/pixel, acquisition time 6:02 minutes).
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8

Ultra-High Field Brain Imaging Protocol

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Four subjects were scanned on a Siemens 7T scanner. Informed consent in accordance with local ethics was obtained before each scan. SMS data were acquired in all 4 subjects, while additional in‐plane undersampling scans were performed on 1 subject.
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9

Quantifying B1+ Maps at 7T MRI

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To achieve the desired phase shifts, the quadrature (for TEM) and pseudo-quadrature (for TTT) cases were implemented by adjusting the lengths of the coaxial cables feeding the coils. Imaging was performed on two volunteers using a 7T scanner (Siemens Medical Solutions, Germany). B1+ maps were acquired with a turbo FLASH sequence with the following parameters: number of flip angles = 6, TR = 2.2 sec, TE = 1.4 msec, FOV = 220 mm, Matrix = 64x64, slice thickness = 3.2 mm and bandwidth = 510 Hz/pixel. The images from the six measurements of the B1+ map sequence was summed and used to create a brain mask. FSL’s brain extraction tool (BET) [50 ] was used to create a brain mask (bet -m -f 0.4 options were used). The created brain masks were visually inspected and corrected manually using ITK SNAP tool [51 ] in the regions where automatic segmentation of the brain failed.
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10

Ultra-high Field MRI Neuroimaging Protocol

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Human studies were conducted on a 7T scanner (Siemens, Erlangen, Germany) with 32 receive-channels, which can operate in a single-transmit (1Tx) or pTx mode. The latter has 16 independent transmit channels with a 1-kW RF power amplifier per channel; only 8 of these channels were employed in this study. The 1Tx mode used a combined 8-kW RF amplifier.
Human brain images were collected in healthy subjects who signed a consent form approved by the local Institutional Review Board. Each subject was scanned first in the pTx mode using the Nova 8Tx32Rx head coil and then in the 1Tx mode using the Nova 1Tx32Rx head coil. To ensure RF safety, the Nova 8Tx32Rx coil was used in the “protected” mode in which total RF power delivery (measured as sum of forward minus reflected power across all of the 8 transmit channels in use) was monitored on the fly to be within the power limits specified by the coil manufacturer. In this study, the power limits were set to 11 W for long-term (6 minutes) and 22 W for short-term (10 seconds) RF exposures. For the 1Tx acquisition, dielectric padding was employed in the Nova 1Tx32Rx coil, as in the 7T HCP dMRI protocol, to improve the B1+ field in lower brain regions.
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