Mmp 2 mmp 3 inhibitor 1

Manufactured by Santa Cruz Biotechnology

The MMP-2/MMP-3 inhibitor I is a laboratory reagent that inhibits the enzymatic activity of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-3 (MMP-3). It can be used in experimental studies to investigate the role of these enzymes in various biological processes.

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Lab products found in correlation

Gi254023x, by Merck Group (4 mentions) Gm6001, by Merck Group (2 mentions) Tapi 2, by Santa Cruz Biotechnology (2 mentions) Gw280264x, by Aobious (2 mentions) Pf 00562271, by Selleck Chemicals (2 mentions) Batimastat, by Selleck Chemicals (2 mentions) Mmp 9 inhibitor 1, by Santa Cruz Biotechnology (2 mentions) Adam10 inhibitor, by Merck Group (2 mentions) Pan mmp inhibitor, by Selleck Chemicals (2 mentions) Mmp 2 mmp 9 inhibitor 2, by Santa Cruz Biotechnology (2 mentions) Arp 100, by R&D Systems (2 mentions) Mmp2 inhibitor, by R&D Systems (2 mentions) Mmp 13 inhibitor, by Santa Cruz Biotechnology (2 mentions) Mmp 9 mmp 13 inhibitor 2, by Santa Cruz Biotechnology (2 mentions) S2672, by Selleck Chemicals (2 mentions) Tapi 1, by Selleck Chemicals (2 mentions) Elastase from porcine pancreas, by Merck Group (1 mentions) Sotalol, by Merck Group (1 mentions) Theophylline, by Merck Group (1 mentions) α2 3 6 8 9 neuraminidase a, by New England Biolabs (1 mentions)

4 protocols using mmp 2 mmp 3 inhibitor 1

Antibodies and Reagents for β1-Adrenergic Receptor Analysis

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Antibodies were from the following sources: rabbit polyclonal anti-β₁AR (Cat# ab3442, raised against residues 394-408 in human β₁-ARs) was from Abcam. Mouse monoclonal anti-FLAG M2 antibody (Cat# F1804) was from Sigma-Aldrich. The Abcam rabbit polyclonal anti-β₁AR was validated in our previous publication.³ IRDye 800CW goat anti-rabbit IgG (Cat# 925-32211) and IRDye 680RD goat anti-mouse IgG (Cat# 925-68070) secondary antibodies were from LI-COR Biosciences. Elastase from porcine pancreas (Cat# E0258), GM6001 (Cat# 364206), GI254023X (ADAM-10 inhibitor, Cat# SML0789), matrix metalloproteinase (MMP)-2/MMP-9 inhibitor I (Cat# 444241), MMP-9/MMP-13 inhibitor I (Cat# 444252), forskolin (Cat# F3917), isoproterenol (Iso) (Cat# 420355), propranolol (Cat# P0884), sotalol (Cat# S0278), and theophylline (Cat# T1633) were from Sigma-Aldrich. MMP-2/MMP-3 inhibitor I (Cat# sc-295483) and TAPI-2 (Cat# sc-205851) were from Santa Cruz Biotechnology. GW280264X (ADAM-10/ADAM-17 inhibitor, Cat# 7030) was from AOBIOUS Inc. α2-3,6,8,9 neuraminidase A (Cat #: P0722) was from New England BioLabs Inc. All other chemicals were reagent grade.

Zhu J, & Steinberg S.F. (2023). Beta1-Adrenergic Receptor Cleavage and Regulation by Elastase. JACC: Basic to Translational Science, 8(8), 976-988.

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Targeted Metalloproteinase Inhibition

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Batimastat at 20nM (Pan MMP inhibitor; BB-94; Selleck Chemicals); MMP-2/MMP-9 Inhibitor II at 50nM (sc-311430; Santa Cruz biotechnology); ARP 100 at 20nM (MMP2 inhibitor) (R&D Systems); MMP-13 Inhibitor at 10nM (sc-205756; Santa Cruz biotechnology); MMP-9 Inhibitor I at 100nM (sc-311437; Santa Cruz biotechnology); MMP-9/MMP-13 Inhibitor II at 10nM (sc-311439; Santa Cruz biotechnology); MMP2/MMP-3 Inhibitor I at 20uM (sc-295483; Santa Cruz biotechnology); TAPI-1 at 20uM (ADAM17 inhibitor; S7434; Selleck Chemicals); GI254023X at 200nM unless otherwise indicated (ADAM10 inhibitor; Sigma Aldrich); PF-00562271 at 5nM (FAK inhibitor; S2672; Selleck Chemicals).

Venkatesh H.S., Tam L.T., Woo P.J., Lennon J., Nagaraja S., Gillespie S.M., Ni J., Duveau D.Y., Morris P.J., Zhao J.J., Thomas C.J, & Monje M. (2017). Targeting neuronal activity-regulated neuroligin-3 dependency in high-grade glioma. Nature, 549(7673), 533-537.

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Targeted Metalloproteinase Inhibition

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Antibody Sources and Inhibitor Reagents

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Antibodies were from the following sources: Rabbit polyclonal anti-βAR (ab3442, raised against residues 394-408 in human β₁AR) was from Abcam (Cambridge, MA). Mouse monoclonal anti-FLAG M2 and ant-β-actin were from Sigma-Aldrich (Saint Louis, MO). Rabbit monoclonal anti-cleaved caspase-3 (Asp175) (5A1E) was from Cell Signaling Technology (Danvers, MA). IRDye 800CW or 680RD goat anti-rabbit or goat anti-mouse IgG (H+L) were from LI-COR Biosciences (Lincoln, NE). GM6001, GI254023X (ADAM-10 inhibitor), MMP-2/MMP-9 inhibitor II, MMP-9/MMP-13 inhibitor II, doxorubicin, and H₂O₂ were from Sigma-Aldrich. MMP-2/MMP-3 inhibitor I and TAPI-2 were from Santa Cruz Biotechnology (Dallas, TX). GW280264X (ADAM-10/ADAM-17 inhibitor) was from AOBIOUS Inc (Hopkinton, MA). All other chemicals were reagent grade.

Zhu J, & Steinberg S.F. (2021). β1-adrenergic receptor N-terminal cleavage by ADAM17; the mechanism for redox-dependent downregulation of cardiomyocyte β1-adrenergic receptors. Journal of molecular and cellular cardiology, 154, 70-79.

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