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C57bl 6j wt mice

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C57BL/6J WT mice are a common inbred strain of laboratory mice. They serve as a standard wild-type control for experiments involving genetically modified mouse models.

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Lab products found in correlation

Vgat chr2 mice, by Jackson ImmunoResearch (2 mentions) Male apoe mice, by Charles River Laboratories (1 mentions)

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C57BL/6J mice C57BL/6J WT mice

4 protocols using c57bl 6j wt mice

1

Genetically Modified Mice Behavioral Study

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MOR-KO and DOR-KO mice were bred in-house. MOR-wild-type (WT) and DOR-WT littermates from heterozygote breedings were used as WT controls. C57BL/6J WT mice were purchased from Taconic Farms. Only male mice were included in the experiments.
Westlund B., Parry D., Clover R., Basson M, & Johnson C.D. (1999). Reverse genetic analysis of Caenorhabditis elegans presenilins reveals redundant but unequal roles for sel-12 and hop-1 in Notch-pathway signaling. Proceedings of the National Academy of Sciences of the United States of America, 96(5), 2497-2502.
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2

Behavioral Experiments on C57Bl/6J and VGAT-ChR2 Mice

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A total of 43 male mice were used in this study and the figure contribution of each mouse is summarized in Supplemental table 1. All mice tested were between 2 and 12 month of age. C57Bl/6J (WT) mice were purchased from Taconic Biosciences and VGAT-ChR2 mice were obtained from the Jackson laboratories. VGAT-cre mice were backcrossed to C57Bl/6J mice for at least six generations. All mice were kept on a 12 h light-dark cycle. All animal experiments were performed according to the guidelines of the US National Institutes of Health and the Institutional Animal Care and Use Committee at the New York University Langone Medical Center.
Schmitt L.I., Wimmer R.D., Nakajima M., Happ M., Mofakham S, & Halassa M.M. (2017). Thalamic amplification of cortical connectivity sustains attentional control. Nature, 545(7653), 219-223.
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3

Murine Aneurysm Induction Protocols

Cited 1 time
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See Study approval for an ethics declaration. The PPE (MilliporeSigma) model was described various times before (13 (link), 44 (link)). Briefly, 10-week-old male C57BL/6J WT mice (Taconic Biosciences) on regular chow diet (R36; Lantmännen) were kept under standard conditions (temperature 22°C, humidity 56%). Similarly, AngII-minipump implantation for AAA induction has been described various times before (19 (link)). Briefly, 10-week-old ApoE–/– male mice (Charles River Laboratories) received an AngII-loaded (Bachem) osmotic minipump (model 2004, DURECT Corporation) implanted subcutaneously. Anesthesia, PPE-AAA induction, AngII-AAA induction, murine B-mode ultrasound images, and protocols for euthanasia and tissue processing are discussed in the Supplemental Data.
Busch A., Pauli J., Winski G., Bleichert S., Chernogubova E., Metschl S., Winter H., Trenner M., Wiegering A., Otto C., Fischer J., Reiser J., Werner J., Roy J., Brostjan C., Knappich C., Eckstein H.H., Paloschi V, & Maegdefessel L. (2021). Lenvatinib halts aortic aneurysm growth by restoring smooth muscle cell contractility. JCI Insight, 6(15), e140364.
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4

Behavioral Experiments on C57Bl/6J and VGAT-ChR2 Mice

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A total of 43 male mice were used in this study and the figure contribution of each mouse is summarized in Supplemental table 1. All mice tested were between 2 and 12 month of age. C57Bl/6J (WT) mice were purchased from Taconic Biosciences and VGAT-ChR2 mice were obtained from the Jackson laboratories. VGAT-cre mice were backcrossed to C57Bl/6J mice for at least six generations. All mice were kept on a 12 h light-dark cycle. All animal experiments were performed according to the guidelines of the US National Institutes of Health and the Institutional Animal Care and Use Committee at the New York University Langone Medical Center.
Schmitt L.I., Wimmer R.D., Nakajima M., Happ M., Mofakham S, & Halassa M.M. (2017). Thalamic amplification of cortical connectivity sustains attentional control. Nature, 545(7653), 219-223.
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