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Model 1004

Manufactured by Durect
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The Model 1004 is a precision laboratory instrument designed for performing various analytical and experimental tasks. The device is capable of accurately measuring, monitoring, and controlling various parameters essential for scientific research and testing. The core function of the Model 1004 is to provide researchers with a reliable and versatile tool for data collection and process control, without interpretation or extrapolation of its intended use.

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Lab products found in correlation

Buprivacaine, by Pfizer (2 mentions) Dimethyl sulfoxide (dmso), by Merck Group (2 mentions) Isoflurane anesthesia, by Baxter (1 mentions) C57bl 6j mice, by Jackson ImmunoResearch (1 mentions) Somnosuite, by Kent Scientific (1 mentions) Angiotensin 2, by Merck Group (1 mentions) Isoflurane, by Baxter (1 mentions) Alzet brain infusion kit 3, by Durect (1 mentions) Isoflo, by Abbott (1 mentions)

Close spelling variants of this product

Alzet model 1004 Alzet mini‐osmotic pumps (Alzet model 1004), Alzet osmotic minipumps (Model 1004, Alzet Micro-Osmotic Pump Model 1004 ALZET® Micro‐Osmotic Pumps (Model 1004)

10 protocols using model 1004

1

Chronic Intracerebroventricular SCD Inhibitor Infusion

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For ICV infusions of SCDi or vehicle, mice were locally injected with buprivacaine (Hospira) and operated under isoflurane anesthesia (Baxter). Brain cannulae attached to Alzet osmotic pumps were stereotaxically implanted at 0.0 mm antero-posterior and 0.9 mm lateral to Bregma and the pumps placed under the back skin according to manufacturer’s instructions. The 28-day Alzet osmotic pumps used in these experiments (0.11 μl/h infusion rate, model 1004; Durect) were primed for 48 h and begin pumping immediately when implanted. Abcam or Cayman SCD inhibitors were dissolved in DMSO (Sigma-Aldrich) and infused at a final concentration of 80 µM in sterile aCSF (148 mM NaCl, 3 mM KCl, 1.7 mM MgCl2, 1.4 mM CaCl2, 1.5 mM Na2PO4, 0.1 mM NaH2PO4). Vehicle pumps contained the same volumes as the SCDi pumps (0.8% DMSO/aCSF).
Hamilton L.K., Moquin-Beaudry G., Mangahas C.L., Pratesi F., Aubin M., Aumont A., Joppé S.E., Légiot A., Vachon A., Plourde M., Mounier C., Tétreault M, & Fernandes K.J. (2022). Stearoyl-CoA Desaturase inhibition reverses immune, synaptic and cognitive impairments in an Alzheimer’s disease mouse model. Nature Communications, 13, 2061.
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2

Murine Model of Oxidative Stress

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Adult male C57BL/6J mice weighing 30 gm were purchased from The Jackson Laboratory (Bar Harbor, ME) and acclimatized for a week with free access to food and water. Four groups of mice were studied after acclimatization; 1) control, mice kept on tap water; (2 (link)) BSO, provided with 10 mmol/L BSO in drinking water; (3 (link)) BSO+ML385, mice intraperitoneally implanted with mini-osmotic pumps (Model 1004, Durect Corporation, Cupertino, CA) to dispense ML385 (10 mg/kg bodyweight/day) and supplemented with BSO and (4 (link)) ML385, implanted with ML385 filled mini-osmotic pumps. Bodyweight of mice was recorded at the start and completion of the 8-week treatment.
Osmotic pump implantation was performed as detailed by Chang et al. (21 (link)). Briefly, anesthesia was induced by 3% isoflurane and maintained by 1.5% isoflurane throughout the surgical procedure using (SomnoSuite, Kent Scientific Corp, Torrington, CT, USA) anesthesia machine. A midline incision was made in the lower abdomen and the drug-filled osmotic pump was inserted, delivery portal first, in the peritoneal cavity.
A day before sacrifice, urine samples were collected for 24 hours by keeping the mice in standard metabolic cages. All experiments were performed in compliance with Institutional Animal Care and Use Committee and NIH guidelines.
Farooqui Z., Mohammad R.S., Lokhandwala M.F, & Banday A.A. (2020). Nrf2 Inhibition Induces Oxidative Stress, Renal Inflammation and Hypertension in Mice. Clinical and experimental hypertension (New York, N.Y. : 1993), 43(2), 175-180.
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3

Angiotensin II-Induced Aortic Aneurysm

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To induce AA formation, mice of 14 weeks or 20 weeks were selected to be surgically implanted with ALZET osmotic mini-pumps (Model 1004, Durect Corporation, Cupertino, CA, USA) to infuse angiotensin II (Sigma-Aldrich) (1.44 mg/kg/d or 2.16 mg/kg/d) for 28 days, as described previously [14 (link)]. In our study, all experiments were conducted using male mice. Controls were age-matched littermates. Four weeks after infusion, mice were euthanized. Aortas were harvested, cleaned, and imaged. Thoracic and abdominal aortas were histochemically stained and evaluated.
Li H., Guo J., Jia Y., Kong W, & Li W. (2021). LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice. Genes, 12(4), 513.
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4

Continuous Brain Infusion of SCD Inhibitor

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For ICV infusions of SCDi or vehicle, mice were locally injected with buprivacaine (Hospira) and operated under isoflurane anesthesia (Baxter). Brain cannulae attached to Alzet osmotic pumps were stereotaxically implanted at 0.0 mm antero-posterior and 0.9 mm lateral to Bregma and the pumps placed under the back skin according to manufacturer's instructions. The 28-day Alzet osmotic pumps used in these experiments (0.11 μl/h infusion rate, model 1004; Durect) were primed for 48 h and began pumping immediately when implanted. The SCD inhibitor was dissolved in DMSO (Sigma-Aldrich) and infused at a final concentration of 80 µM in sterile aCSF (148 mM NaCl, 3 mM KCl, 1.7 mM MgCl2, 1.4 mM CaCl2, 1.5 mM Na2PO4, 0.1 mM NaH2PO4). Vehicle pumps contained the same volumes as the SCDi pumps (0.8% DMSO/aCSF).
Hamilton L.K., M’Bra P.E., Mailloux S., Galoppin M., Aumont A, & Fernandes K.J. (2024). Central inhibition of stearoyl-CoA desaturase has minimal effects on the peripheral metabolic symptoms of the 3xTg Alzheimer’s disease mouse model. Scientific Reports, 14, 7742.
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5

Evaluating 12,13-EpOMEs in Colon Cancer

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C57BL/6 male mice (age = 6 weeks) were subcutaneously implanted with osmotic mini-pumps (Durect, model 1004), which contained vehicle (a 1:1 vol/vol mixed solution of DMSO and PEG 400) or 12,13-EpOMEs (dose = 2 mg/kg/day). After one week of mini-pump implantation, 4 × 105 MC38 colon cancer cells (purchased from Kerafast, catalog number ENH204, cell line authentication and mycoplasma testing have been verified by company) in 100 μL PBS were subcutaneously injected into each mouse to initiate primary tumor growth. Tumor size was measured using caliper, at the end of the experiment, the tumors were dissected, weighed and subjected to biochemical analysis.
Wang W., Yang J., Edin M.L., Wang Y., Luo Y., Wan D., Yang H., Song C.Q., Xue W., Sanidad K.Z., Song M., Bisbee H.A., Bradbury J.A., Nan G., Zhang J., Shih P.A., Lee K.S., Minter L.M., Kim D., Xiao H., Liu J.Y., Hammock B.D., Zeldin D.C, & Zhang G. (2019). Targeted metabolomics identifies the cytochrome P450 monooxygenase eicosanoid pathway as a novel therapeutic target of colon tumorigenesis. Cancer research, 79(8), 1822-1830.
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6

Intracerebroventricular Infusion in Mice

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Implantation of an infusion cannula into the cerebral ventricles and an osmotic pump were performed on mice according to our previously reported method.18 Briefly, the mice were anesthetized with 1.5% to 2% isoflurane through a face mask, and stainless steel cannulas (ALZET Brain Infusion Kit3, Durect Co, Cupertino, CA) were implanted in the right lateral ventricle, placed 1.0 mm lateral and 0.5 mm posterior from the bregma. The cannulas were fixed on the skull, and catheters were attached to extension tubes and linked to the ALZET osmotic pumps (Model 1004, Durect Co, Cupertino, CA), which were installed in subcutaneous pockets on the lateral backs of the mice.
Takane K., Hasegawa Y., Lin B., Koibuchi N., Cao C., Yokoo T, & Kim‐Mitsuyama S. (2017). Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure. Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 6(4), e004897.
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7

Subcutaneous Nimbidiol Delivery in Mice

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Under isoflurane anaesthesia, an incision was made along dorsal midline of the mice to form a subcutaneous pocket in the right flank using sterile forceps and blunt-tipped scissors. Saline or Nimbidiol-laden ALZET micro-osmotic pumps (Model 1004, DURECT Corporation, CA, USA) were implanted in the subcutaneous pocket for the delivery of Nimbidiol at the dose of 0.40 mg kg−1 d−1 for eight weeks.
Juin S.K., Pushpakumar S., Tyagi S.C, & Sen U. (2022). Glucosidase inhibitor, Nimbidiol ameliorates renal fibrosis and dysfunction in type-1 diabetes. Scientific Reports, 12, 21707.
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8

Implantable Osmotic Pump Delivery of PQQ

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ALZET® osmotic pumps (Model # 1004, 1.5 cm in length, 0.6 cm in diameter, 0.4 g weight, 28 day delivery at a pumping rate of 0.11 μl/h) were obtained from Durect Corporation (Cupertino, CA, USA). PQQ (Cat. No. 164–17083) was purchased from Wako Pure Chemical Industries, Ltd. (Japan). Other high-grade reagents and chemicals were purchased from local commercial companies.
Kuo Y.T., Shih P.H., Kao S.H., Yeh G.C, & Lee H.M. (2015). Pyrroloquinoline Quinone Resists Denervation-Induced Skeletal Muscle Atrophy by Activating PGC-1α and Integrating Mitochondrial Electron Transport Chain Complexes. PLoS ONE, 10(12), e0143600.
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9

Angiotensin II-Induced Hypertension in Mice

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Mice with telemetric BP transducers implanted were anesthetized with 1.5% inhalational isoflurane (IsoFlo, Abbott Animal Health, Abbott Park, IL), weighed, and were then implanted subcutaneously an Alzet osmotic minipump (Model 1004, Durect Corporation, Cupertino, CA) filled with Ang II (350 ng kg−1 min−1). Mice were then treated with Ang II and high (6%) dietary salt intake for 4 weeks.
Wang Y., Chen L., Li M., Cha H., Iwamoto T, & Zhang J. (2015). Conditional knockout of smooth muscle sodium calcium exchanger type‐1 lowers blood pressure and attenuates Angiotensin II‐salt hypertension. Physiological Reports, 3(1), e12273.
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10

Angiotensin II Infusion in Transplant Mice

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Five weeks after BMT, the ApoE−/− recipient mice or the WT recipient mice were implanted with an osmotic pump (ALZET micro-osmotic pump MODEL 1004, DURECT Co., Cupertino, CA, USA)22 (link) and angiotensin II (Ang II) (1900 ng/kg per min) or saline was continuously infused for 4 weeks.23 (link),24 (link)
Yokokawa T., Misaka T., Kimishima Y., Wada K., Minakawa K., Sugimoto K., Ishida T., Morishita S., Komatsu N., Ikeda K, & Takeishi Y. (2021). Crucial role of hematopoietic JAK2 V617F in the development of aortic aneurysms. Haematologica, 106(7), 1910-1922.
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