Discovery mr750 3t system

Manufactured by GE Healthcare

Sourced in United States

The Discovery MR750 3T system is a high-field magnetic resonance imaging (MRI) scanner developed by GE Healthcare. It operates at a magnetic field strength of 3 Tesla, providing enhanced image quality and detail compared to lower-field MRI systems. The core function of the Discovery MR750 3T is to generate detailed images of the human body for diagnostic and clinical applications.

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Discovery MR750 3T MR system Discovery MR750 3T MRI system 3T Discovery MR750 Discovery MR750 system Discovery MR750 3T Discovery MR750 system MR750

5 protocols using discovery mr750 3t system

3T MRI Diffusion Tensor Imaging of Sedated Children

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MRI scans were acquired on a GE Discovery MR750 3 T system at the First Affiliated Hospital of Jinan University, China. An eight-channel phased-array head coil was used for the imaging experiments. The children were sedated for imaging using oral chloral hydrate (0.8~0.9 ml/kg). A pediatrician trained in MRI procedures was in attendance throughout the examination. The DTI scan consisted of a single-shot diffusion-weighted EPI sequence with the following parameters: TR/TE = 5000/70 ms, matrix = 256 * 256, FOV = 256 mm, slice thickness = 3 mm without gap, number of slices = 46 axial slices, diffusion directions = 25, b-values = 0 and 1000 s/mm2. A 3D-BRAVO sequence was collected for anatomical localization with the following parameters: TR/TE = 8.2/3.2 ms, inversion time (TI) = 450 ms, flip angle = 12°, matrix = 256 * 256, FOV = 240 mm, slice thickness = 1.0 mm without gap.

Hu Y., Chen Z., Huang L., Xi Y., Li B., Wang H., Yan J., Lee T.M., Tao Q., So K.F, & Ren C. (2017). A translational study on looming-evoked defensive response and the underlying subcortical pathway in autism. Scientific Reports, 7, 14755.

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T1-weighted MRI Acquisition and Brain Tissue Segmentation

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Three-dimensional, T1-weighted images for each participant were acquired at Taipei Veterans General Hospital by using a Discovery MR750 3T system (GE Healthcare, Chicago, IL, USA), with a rapid acquisition gradient echo. All the participants were instructed to close their eyes, hold still, and relax during the acquisition. The image parameters were repitition time (TR) = 12.2 ms, echo time (TE) = 5.2 ms, flip angle = 12°, field of view (FOV) = 256 × 256 × 168 mm³, matrix size = 256 × 256 × 168, slice thickness = 1 mm, and voxel size = 1 × 1 × 1 mm³.
The skull-stripping and intensity non-uniformity correction on the T1-weighted images were performed using a hybrid watershed algorithm [38 (link)], as well as nonparametric, nonuniform intensity normalization [39 (link)] implemented by the Freesurfer software (http://surfer.nmr.mgh.harvard.edu). The brain tissue was then further segmented into GM, WM, and cerebrospinal fluid (CSF) areas by using the Statistical Parametric Mapping 12 package (http://www.fil.ion.ucl.ac.uk/spm).

Lu C.F., Wu Y.T., Teng S., Wang P.S., Tu P.C., Su T.P., Jao C.W, & Li C.T. (2019). Genetic Predisposition and Disease Expression of Bipolar Disorder Reflected in Shape Changes of the Anterior Limbic Network. Brain Sciences, 9(9), 240.

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SNR Evaluation of MRI Phantom and In-Vivo Imaging

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All experiments were performed on a GE Discovery MR750 3 T system. For the in-vitro experiments, the coil was loaded with a standard homogeneous rectangular (

33 cm \times 22 cm \times 16 cm

) phantom. Phantom images were acquired using a fast spin echo sequence with the following parameters:

T R = 315

ms,

T E = 68.7

ms,

1 mm \times 1 mm \times 3 mm

N E X = 1

. For in-vivo experiments, a healthy volunteer (F, Age = 29) was used. In-vivo images were acquired using the same fast spin echo sequence. The SNR values were calculated according to Method 4 described in the NEMA Standards Publication MS 1-2008 (R2014, R2020), as the ratio of the mean pixel value of signal within the specified ROI divided by the standard deviation of the noise calculated in the background region of the image, well removed from the phantom and any visible artifacts. The SNR maps were calculated by dividing the entire image by the standard deviation of the noise calculated as described above. The study was performed with ethical approval from the Weill Cornell Medicine Institutional Review Board and in accordance with all applicable regulations. Informed consent was obtained from the volunteer.

Motovilova E., Tan E.T., Taracila V., Vincent J.M., Grafendorfer T., Shin J., Potter H.G., Robb F.J., Sneag D.B, & Winkler S.A. (2021). Stretchable self-tuning MRI receive coils based on liquid metal technology (LiquiTune). Scientific Reports, 11, 16228.

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Alt-SSFP fMRI Comparison at 3T

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All experiments were performed on a GE Discovery MR750 3T system (50 mT/m maximum gradient strength and 200 mT/m/ms maximum slew rate) with a 32-channel head coil (Nova Medical Inc.). A total of 11 normal and healthy volunteers participated in the study with the approval of the Stanford University Institutional Review Board (6 males, 5 females). All subjects were individually recruited for breath-hold and visual studies; some subjects participated in both studies in separate sessions.
Alt-SSFP experiments were conducted with the following parameters: TR = 14.3 ms, flip angle = 35°, acquisition matrix = 80 × 80 × 22, receiver bandwidth = ±62.5 kHz. Two dummy scans were acquired in the beginning of each scan, in addition to one fully-sampled reference scan used for GRAPPA reconstruction. For comparison, a 2D single-shot EPI GRE sequence was performed with a flip angle = 77°, and TE = 30 ms. The TR of the GRE sequence was prescribed as the total time to acquire all the 2D slices, which was made equal to the total volume time of the 3D alt-SSFP sequence (3.46 s). GRE-EPI and alt-SSFP fMRI experiments were conducted with identical spatial and temporal resolution for each type of stimulus study. A high resolution T₁-weighted anatomical scan was obtained after each set of fMRI scans for co-registration and group-analysis purposes.

Jou T., Patterson S., Pauly J.M, & Bowen C.V. (2015). Fat-suppressed Alternating-SSFP for Whole-Brain fMRI using Breath-hold and Visual Stimulus Paradigms. Magnetic resonance in medicine, 75(5), 1978-1988.

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Resting-State fMRI Acquisition Protocol

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Scanning was performed on a General Electric Discovery MR750 3 T system (Milwaukee, WI, USA) at the Institute of Psychiatry, Psychology & Neuroscience, King's College London. For the rs-fMRI, participants were asked to lie still with their eyes open, and to think of nothing in particular while a fixation cross was displayed in the center of a screen which they viewed through a mirror system. Scanning time for the rs-fMRI was 12 min. During this time, ME-EPI images sensitive to BOLD contrast were acquired to measure hemodynamic responses (repetition time: 2500 ms; echo times, 12, 28, 44, 60 ms; flip angle, 80°; 4.0 × 4.0 × 3.0-mm voxels; field of view, 240; 32 axial sections collected with sequential (top down) acquisition and 1-mm interslice gap). A structural scan was acquired for co-registration of the ME-EPI data by means of a three-dimensional T1-weighted inversion recovery-prepared gradient echo sequence (voxel size: 1.05 × 1.05 × 1.2 mm, field of view: 270 mm, 196 slices, repetition time: 7.3 ms, echo time: 3.0 ms, inversion time: 400 ms).

Waltmann M., O'Daly O., Egerton A., McMullen K., Kumari V., Barker G.J., Williams S.C, & Modinos G. (2018). Multi-echo fMRI, resting-state connectivity, and high psychometric schizotypy. NeuroImage : Clinical, 21, 101603.

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